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Transmembrane Transporters
Voltage-gated ion channels
Transient Receptor Potential channels (TRP)
AMG2850 - 99%, high purity , CAS No.1470018-52-0

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AMG2850 - 99%, high purity , CAS No.1470018-52-0

≥99%

CAS#: 1470018-52-0
Formula: C₁₉H₁₇F₆N₃O
Molecular Weight: 417.35
PubChem CID: 90655362

Item Number

A646173

Grouped product items
SKU	Size	Availability	Price
A646173-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$335.90
A646173-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$570.90
A646173-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,131.90

View related series

Membrane Transporter/Ion Channel Neuronal Signaling TRP Channel

Basic Description

Specifications & Purity	99%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist Form:Solid IC50& Target:TRPM8

Associated Targets(Human)

TRPM8 Tclin Transient receptor potential cation channel subfamily M member 8 (1 Activities)

Discover Target: TRPM8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpm8 Transient receptor potential cation channel subfamily M member 8 (889 Activities)

Discover Target: Trpm8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Liver microsome (341 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	(8R)-8-[4-(trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]-6,8-dihydro-5H-1,7-naphthyridine-7-carboxamide
INCHI	InChI=1S/C19H17F6N3O/c1-11(18(20,21)22)27-17(29)28-10-8-12-3-2-9-26-15(12)16(28)13-4-6-14(7-5-13)19(23,24)25/h2-7,9,11,16H,8,10H2,1H3,(H,27,29)/t11-,16+/m0/s1
InChi Key	DDBWYSSPWMXBIY-MEDUHNTESA-N
Canonical SMILES	CC(C(F)(F)F)NC(=O)N1CCC2=C(C1C3=CC=C(C=C3)C(F)(F)F)N=CC=C2
Isomeric SMILES	C[C@@H](C(F)(F)F)NC(=O)N1CCC2=C([C@H]1C3=CC=C(C=C3)C(F)(F)F)N=CC=C2
PubChem CID	90655362
MeSH Entry Terms	8-(4-(trifluoromethyl)phenyl)-N-(1,1,1-trifluoropropan-2-yl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide;AMG2850
Molecular Weight	417.35

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Solubility	DMSO : 100 mg/mL (239.61 mM; Need ultrasonic)

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