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Amiloride HCl dihydrate - ≥98%, high purity , Amiloride-sensitive sodium channel, ENaC blocker, CAS No.17440-83-4, Amiloride-sensitive sodium channel, ENaC blocker

≥98%

CAS#: 17440-83-4
Formula: C₆H₈ClN₇O·HCl·2H₂O
Molecular Weight: 302.12
PubChem CID: 68540
PubChem SID: 488184173

Item Number

A129545

Grouped product items
SKU	Size	Availability	Price
A129545-200mg	200mg	In stock	$92.90
A129545-1g	1g	In stock	$205.90
A129545-5g	5g	In stock	$686.90
A129545-25g	25g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,403.90

Basic Description

Synonyms	Amiloride hydrochloride dihydrate\|17440-83-4\|Amiloride HCl dihydrate\|Modamide\|Amilorid hydrochlorid-2-wasser\|Amiloride hydrochloride [USAN:USP]\|CHEBI:2640\|FZJ37245UC\|MK-870 hydrochloride dihydrate\|N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochl
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Amiloride hydrochloride dihydrate is a potent epithelial sodium channel blocker and selective low threshold (T-type) calcium channel protein inhibitor (KD=30μM).
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	BLOCKER
Mechanism of action	Amiloride-sensitive sodium channel, ENaC blocker
Product Description	Amiloride HCl dihydrate is a potent epithelial sodium channel blocker. An epithelial sodium channel blocker

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

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CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 0 Activities

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SLC9A1 Tchem Sodium/hydrogen exchanger 1 0 Activities

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] 0 Activities

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LMNA Tbio Prelamin-A/C 0 Activities

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PLAU Tchem Urokinase-type plasminogen activator 0 Activities

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GLA Tclin Alpha-galactosidase A 0 Activities

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ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

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THRB Tclin Thyroid hormone receptor beta 0 Activities

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KDM4E Tchem Lysine-specific demethylase 4E 0 Activities

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Names and Identifiers

Pubchem Sid	488184173
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488184173
IUPAC Name	3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;dihydrate;hydrochloride
INCHI	InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
InChi Key	LTKVFMLMEYCWMK-UHFFFAOYSA-N
Canonical SMILES	C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl
Isomeric SMILES	C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.O.O.Cl
PubChem CID	68540
Molecular Weight	302.12

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
C2304014	Certificate of Analysis	Mar 31, 2023	A129545
C23031362	Certificate of Analysis	Mar 31, 2023	A129545
C23031320	Certificate of Analysis	Mar 07, 2023	A129545
D2110236	Certificate of Analysis	Jan 16, 2023	A129545
D2110237	Certificate of Analysis	Jan 16, 2023	A129545
D2110238	Certificate of Analysis	Jan 16, 2023	A129545
G2409083	Certificate of Analysis	Jan 16, 2023	A129545
H2413029	Certificate of Analysis	Jan 16, 2023	A129545
B1512004	Certificate of Analysis	Sep 09, 2022	A129545
J2316014	Certificate of Analysis	Sep 09, 2022	A129545

Solubility

Soluble in water (1 mg/ml, warm), DMSO (60 mg/ml at 25 °C), and ethanol (< 1 mg/ml at 25 °C).

Melt Point(°C)

293.5°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects H300:Fatal if swallowed
Precautionary Statements	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help.

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