Amiloride hydrochloride hydrate - ≥98%, high purity , CAS No.2016-88-8

35 Citations
  • ≥98%
Item Number
A131615
Grouped product items
SKUSizeAvailabilityPrice Qty
A131615-1g
1g
In stock
$172.90
A131615-5g
5g
In stock
$615.90

eNaC blocker

Basic Description

SynonymsSPECTRUM1500112 | CAA01688 | CHEBI:84743 | NCGC00093608-01 | Amiloride hydrochloride (Midamor) | AMILORIDE HYDROCHLORIDE [MI] | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide hydrochloride | 3,5-diamino-N-[amino(imino)methyl]-6-chloropy
Specifications & Purity≥98%
Biochemical and Physiological MechanismsSelective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).Epithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na + /H+ exchange pathway. Also
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Amiloride ? HCl is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel (Polycystic kidney disease 2-like 1 protein: PKD2L1), a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE (sodium/hydgrogen exchanger). Amiloride is also an epithelial sodium channel protein inhibitor, which inhibits sodium reabsorption without affecting potassium concentrations. Amiloride serves as a non-selective acid-sensing ion channel (ASIC) blocker and a selective inhibitor of uPA (urokinase plasminogen activator). Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein.
A calcium channel andsodium channel protein inhibitor

Associated Targets(Human)

ESR1 Tclin Estrogen receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ERG Tbio Transcriptional regulator ERG (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR3C1 Tclin Glucocorticoid receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CBX1 Tbio Chromobox protein homolog 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
RORC Tchem Nuclear receptor ROR-gamma (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
FTL Tbio Ferritin light chain (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HSD17B10 Tchem 3-hydroxyacyl-CoA dehydrogenase type-2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD(+)] (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
LMNA Tbio Prelamin-A/C (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GAA Tclin Lysosomal alpha-glucosidase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MBNL1 Tbio Muscleblind-like protein 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NR1I2 Tchem Nuclear receptor subfamily 1 group I member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GLA Tclin Alpha-galactosidase A (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ALDH1A1 Tchem Retinal dehydrogenase 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SMPD1 Tchem Sphingomyelin phosphodiesterase (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GLP1R Tclin Glucagon-like peptide 1 receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CXCL8 Tchem Interleukin-8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KDM4E Tchem Lysine-specific demethylase 4E (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MTOR Tclin Serine/threonine-protein kinase mTOR (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CXCL8 Tchem Interleukin-8 (642 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GBA1 Tclin Beta-glucocerebrosidase (14647 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GAA Tclin Lysosomal alpha-glucosidase (35701 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMPD1 Tchem Sphingomyelin phosphodiesterase (13561 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Lymphoblastoid cell (5959 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ERG Tbio Transcriptional regulator ERG (5589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MBNL1 Tbio Muscleblind-like protein 1 (34431 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Trypsin (394 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rorc Nuclear receptor ROR-gamma (89407 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FTL Ferritin light chain (43324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nr1i2 Nuclear receptor subfamily 1 group I member 2 (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488182216
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488182216
IUPAC Name 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride
INCHI InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
InChi Key ACHKKGDWZVCSNH-UHFFFAOYSA-N
Canonical SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl
Isomeric SMILES C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl
RTECS UQ2275500
PubChem CID 16230
UN Number 2811
Packing Group I
Molecular Weight 266.09
Reaxy-Rn 4038903

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot NumberCertificate TypeDateItem
H2420050Certificate of AnalysisAug 24, 2024 A131615
A2405054Certificate of AnalysisJan 09, 2024 A131615
K2108783Certificate of AnalysisAug 14, 2023 A131615
C2304228Certificate of AnalysisMar 31, 2023 A131615
D2310197Certificate of AnalysisJun 24, 2022 A131615
I1416113Certificate of AnalysisJun 24, 2022 A131615
I2308216Certificate of AnalysisJun 24, 2022 A131615

Chemical and Physical Properties

SolubilitySoluble in DMSO (25 mg/ml), water (10 mM warm), and methanol. Insoluble in chloroform, and ethanol.
Melt Point(°C)299°C(lit.)

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H301:Toxic if swallowed

H412:Harmful to aquatic life with long lasting effects

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

RTECS UQ2275500
Reaxy-Rn 4038903
Class 6.1

Related Documents

Citations of This Product

1. Li Meng, Panpan Zhao, Yucheng Jiang, Jiawen You, Zhiyan Xu, Kui Yu, Aldo R. Boccaccini, Kai Zheng, Junqing Ma.  (2023)  Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model.  Acta Biomaterialia,      [PMID:38040077]
2. Tao Wanjun, Xie Pei, Huang Chengyuan, Wang Ying, Huang Yu, Yin Zongning.  (2023)  Construction of PLGA nanoparticles modified with RWrNM and DLPC and their application in acute rhinosinusitis.  Drug Delivery and Translational Research,    (1): (1-14).  [PMID:37966678]
3. Shui Ling Yi, Zi Ling Li, Yan Chun Gong, Xiang Yuan Xiong.  (2023)  Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density.  LANGMUIR,  39  (45): (15920–15931).  [PMID:37922445]
4. Gongxi Qiao, Xuming Pan, Mengyun He, Ruixi Peng, Xiangrong Huang, Cunpeng Nie, Jianhui Jiang, Xia Chu.  (2023)  An ultrathin Zn-based layered double hydroxides augment degradation of mutant p53 to improve tumor therapy.  CHEMICAL ENGINEERING JOURNAL,  475  (13): (146449).  [PMID:27619977]
5. Jianbo Li, Yaru Xu, Jieke Zhang, Qinglian Li, Chenxu Wang, Zhe Wu, Weijing Yang, Meng Xu, Zhenzhong Zhang, Lei Wang, Jinjie Zhang.  (2023)  Bioinspired fine-tuning of the mechanical rigidity of SNEDDS for the efficient crossing of multiple gastrointestinal barriers.  JOURNAL OF CONTROLLED RELEASE,  362  (170).  [PMID:37625600]
6. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai.  (2023)  Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation.  MATERIALS & DESIGN,  233  (112212).  [PMID:]
7. Zhanlin Zhang, Hui Yan, Wenxiong Cao, Shuang Xie, Pan Ran, Kun Wei, Xiaohong Li.  (2023)  Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment.  ACS Nano,      [PMID:37515593]
8. Zhicheng Le, Qi Pan, Zepeng He, Hong Liu, Yi Shi, Lixin Liu, Zhijia Liu, Yuan Ping, Yongming Chen.  (2023)  Direct Cytosolic Delivery of Proteins and CRISPR-Cas9 Genome Editing by Gemini Amphiphiles via Non-Endocytic Translocation Pathways.  ACS Central Science,      [PMID:37521791]
9. Wenjing Huang, Li Wang, Hao Zhang, Zhihao Han, Yueqing Gu.  (2023)  Near-infrared targeted EGFR fluorescent probe for tumor imaging and diagnosis.  SENSORS AND ACTUATORS B-CHEMICAL,  393  (134102).  [PMID:]
10. Ping Guan, Zhaoxu Meng, Xinran Liu, Jiaxiang Mu, Zichun Gao, Xinrong Yu, He Lian.  (2023)  A biomimetic mineralization nanosystem based on glycolysis-oxidative stress-autophagy regulation for the suppression of malignant tumor and lung metastasis.  CHEMICAL ENGINEERING JOURNAL,  468  (143730).  [PMID:]
11. Shengnan Huang, Chengzhi Song, Jinxin Miao, Xiali Zhu, Yongyan Jia, Yafei Liu, Dongjun Fu, Benyi Li, Mingsan Miao, Shaofeng Duan, Zhenzhong Zhang, Yurong Hu.  (2023)  Red blood cell membrane-coated functionalized Au nanocage as a biomimetic platform for improved MicroRNA delivery in hepatocellular carcinoma.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  642  (123044).  [PMID:37178790]
12. Jinhui Lu, Xiaomeng Zhu, Meng Zhang, Xunchan Jiang, Wei Guo, Feng Jiang, Feng Cao.  (2023)  In vitro and in vivo assessment of structural integrity for HPCD complex@Liposome nanocomposites from ocular surface to the posterior segment of the eye.  CARBOHYDRATE POLYMERS,  315  (120960).  [PMID:37230631]
13. Chang Ni, Zijun Zhang, Yuling Wang, Zhenhai Zhang, Xueping Guo, Huixia Lv.  (2023)  Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention.  JOURNAL OF CONTROLLED RELEASE,  357  (432).  [PMID:37004799]
14. Shi-Jie Hao, Ya-Xuan Zhu, Fu-Gen Wu.  (2023)  Membrane fusion-mediated delivery of small-molecule HER2 tyrosine kinase inhibitor for effective tumor chemosensitization.  JOURNAL OF CONTROLLED RELEASE,  357  (222).  [PMID:36958404]
15. Junwu Wei, Yuan Liu, Yingxin Li, Zhanlin Zhang, Jie Meng, Shuang Xie, Xiaohong Li.  (2023)  Photothermal Propelling and Pyroelectric Potential-Promoted Cell Internalization of Janus Nanoparticles and Pyroelectrodynamic Tumor Therapy.  Advanced Healthcare Materials,  12  (18): (2300338).  [PMID:36857737]
16. Yanzhi Xing, Yulong Xu, Yanna Lin, E Shuang, Han Leng, Jianhua Wang, Xuwei Chen.  (2023)  Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  640  (626).  [PMID:36889060]
17. Yuan Gao, Yingxi Zhang, Hong Xia, Yuqing Ren, Haibin Zhang, Siwen Huang, Meiju Li, Yongjun Wang, Heran Li, Hongzhuo Liu.  (2023)  Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy.  DRUG DELIVERY,  30  (1): (2183814).  [PMID:36843529]
18. Xufeng Yang, Yongrui Peng, Yu-e Wang, Yuxiu Zheng, Yiming He, Jiali Pan, Nan Liu, Yongxin Xu, Renhuan Ma, Junqiu Zhai, Yan Ma, Shixia Guan.  (2023)  Curcumae Rhizoma Exosomes-like nanoparticles loaded Astragalus components improve the absorption and enhance anti-tumor effect.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  81  (104274).  [PMID:]
19. Nini Xin, Dong Gao, Borui Su, Ting Zhou, Yuda Zhu, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan.  (2023)  Orange-Emissive Carbon Dots with High Photostability for Mitochondrial Dynamics Tracking in Living Cells.  ACS Sensors,  (3): (1161–1172).  [PMID:36795996]
20. Zhanlin Zhang, Tian Xia, Pan Ran, Junwu Wei, Jie Meng, Guiyuan Zhang, Xiaohong Li.  (2023)  Persistent luminescence-activated Janus nanomotors with integration of photodynamic and photothermal cancer therapies.  CHEMICAL ENGINEERING JOURNAL,  457  (141226).  [PMID:]
21. Li Fangyuan, Sun Heng, Ren Jiafeng, Zhang Bo, Hu Xi, Fang Chunyan, Lee Jiyoung, Gu Hongzhou, Ling Daishun.  (2022)  A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance.  Nature Communications,  13  (1): (1-16).  [PMID:36450764]
22. Guo Yuxin, Wang Shao-Zhe, Zhang Xinping, Jia Hao-Ran, Zhu Ya-Xuan, Zhang Xiaodong, Gao Ge, Jiang Yao-Wen, Li Chengcheng, Chen Xiaokai, Wu Shun-Yu, Liu Yi, Wu Fu-Gen.  (2022)  In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses.  Nature Communications,  13  (1): (1-20).  [PMID:36319625]
23. Jie Yang, Xiuhua Pan, Jun Zhang, Siyu Ma, Jianeng Zhou, Zengguang Jia, Yawen Wei, Zengyi Liu, Ning Yang, Qi Shen.  (2022)  Reprogramming dysfunctional dendritic cells by a versatile metabolism nano-intervenor for enhancing cancer combinatorial immunotherapy.  Nano Today,  46  (101618).  [PMID:]
24. Yanyan Wang, Hai Gao, Xinya Huang, Zhaoan Chen, Pengyu Kang, Yunyi Zhou, Danhua Qin, Wenli Zhang, Jianping Liu.  (2022)  Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.  CARBOHYDRATE POLYMERS,  292  (119632).  [PMID:35725197]
25. Jie Zhao, Fei Wu, Qiang He, Yawei Feng.  (2022)  Enhanced degradation of amiloride over Bi2FeNbO7/bisulfite process: Key factors and mechanism.  CHEMOSPHERE,  300  (134573).  [PMID:35436455]
26. Yu Zou, Quan Zhou, Yinan Zhao, Defu Zhi, Huiying Chen, Rui Wang, Benzhi Ju, Shubiao Zhang.  (2022)  Structure–activity relationships of pH-responsive and ionizable lipids for gene delivery.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  617  (121596).  [PMID:35181463]
27. Lijuan Yang, Shaochi Liu, Tian Quan, Yongqing Tao, Meng Tian, Luchun Wang, Junji Wang, Dandan Wang, Die Gao.  (2022)  Sulfuric-acid-mediated synthesis strategy for multi-colour aggregation-induced emission fluorescent carbon dots: Application in anti-counterfeiting, information encryption, and rapid cytoplasmic imaging.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  612  (650).  [PMID:35030344]
28. Li Wu, Yan Shi, Zihui Ni, Tao Yu, Zhipeng Chen.  (2022)  Preparation of a Self-Assembled Rhein–Doxorubicin Nanogel Targeting Mitochondria and Investigation on Its Antihepatoma Activity.  MOLECULAR PHARMACEUTICS,  19  (1): (35–50).  [PMID:34890210]
29. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang.  (2021)  Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis.  Advanced Healthcare Materials,  11  (2): (2101926).  [PMID:34738742]
30. Cuiping Jiang, Yuan Wang, Peiyi Liang, Yao Chen, Ziming Zhuang, Lu Zhang, Yankui Yi, Li Liu, Qiang Liu.  (2021)  ATP-Responsive Multifunctional Supramolecular Polymer as a Nonviral Vector for Boosting Cholesterol Removal from Lipid-Laden Macrophages.  ACS Biomaterials Science & Engineering,  (11): (5048–5063).  [PMID:34648280]
31. Haodong Cui, Min Jiang, Wenhua Zhou, Ming Gao, Rui He, Yifan Huang, Paul K. Chu, Xue-Feng Yu.  (2021)  Carrier-Free Cellular Transport of CRISPR/Cas9 Ribonucleoprotein for Genome Editing by Cold Atmospheric Plasma.  Biology-Basel,  10  (10): (1038).  [PMID:34681136]
32. Chi H, Gu Y, Xu T, Cao F.  (2017)  Multifunctional organic-inorganic hybrid nanoparticles and nanosheets based on chitosan derivative and layered double hydroxide: cellular uptake mechanism and application for topical ocular drug delivery..  Int J Nanomedicine,  12  (3): (1607-1620).  [PMID:28280329]
33. Xu T, Xu X, Gu Y, Fang L, Cao F.  (2018)  Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery..  Int J Nanomedicine,  13  (3): (917-937).  [PMID:29491707]
34. Wang Y, Zhou L, Fang L, Cao F.  (2020)  Multifunctional carboxymethyl chitosan derivatives-layered double hydroxide hybrid nanocomposites for efficient drug delivery to the posterior segment of the eye..  Acta Biomater,  104  (3): (104-114).  [PMID:31931169]
35. Kambere Amerigos Daddy J C,Minglei Chen,Faisal Raza,Yanyu Xiao,Zhigui Su,Qineng Ping.  (2020-02-28)  Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia..  Pharmaceutics,  12  ((2)):   [PMID:32102214]

References

1. Shi JM et al..  (2020)  Endocytosis Is a Key Mode of Interaction between Extracellular ß-Amyloid and the Cell Membrane..  Biophys J,  119  (6): (1078-1090).  [PMID:32857960]
2. Jullié D et al..  (2014)  Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites..  J Neurosci,  34  (33): (11106-18).  [PMID:25122907]
3. Li Meng, Panpan Zhao, Yucheng Jiang, Jiawen You, Zhiyan Xu, Kui Yu, Aldo R. Boccaccini, Kai Zheng, Junqing Ma.  (2023)  Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model.  Acta Biomaterialia,      [PMID:38040077]
4. Tao Wanjun, Xie Pei, Huang Chengyuan, Wang Ying, Huang Yu, Yin Zongning.  (2023)  Construction of PLGA nanoparticles modified with RWrNM and DLPC and their application in acute rhinosinusitis.  Drug Delivery and Translational Research,    (1): (1-14).  [PMID:37966678]
5. Shui Ling Yi, Zi Ling Li, Yan Chun Gong, Xiang Yuan Xiong.  (2023)  Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density.  LANGMUIR,  39  (45): (15920–15931).  [PMID:37922445]
6. Gongxi Qiao, Xuming Pan, Mengyun He, Ruixi Peng, Xiangrong Huang, Cunpeng Nie, Jianhui Jiang, Xia Chu.  (2023)  An ultrathin Zn-based layered double hydroxides augment degradation of mutant p53 to improve tumor therapy.  CHEMICAL ENGINEERING JOURNAL,  475  (13): (146449).  [PMID:27619977]
7. Jianbo Li, Yaru Xu, Jieke Zhang, Qinglian Li, Chenxu Wang, Zhe Wu, Weijing Yang, Meng Xu, Zhenzhong Zhang, Lei Wang, Jinjie Zhang.  (2023)  Bioinspired fine-tuning of the mechanical rigidity of SNEDDS for the efficient crossing of multiple gastrointestinal barriers.  JOURNAL OF CONTROLLED RELEASE,  362  (170).  [PMID:37625600]
8. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai.  (2023)  Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation.  MATERIALS & DESIGN,  233  (112212).  [PMID:]
9. Zhanlin Zhang, Hui Yan, Wenxiong Cao, Shuang Xie, Pan Ran, Kun Wei, Xiaohong Li.  (2023)  Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment.  ACS Nano,      [PMID:37515593]
10. Zhicheng Le, Qi Pan, Zepeng He, Hong Liu, Yi Shi, Lixin Liu, Zhijia Liu, Yuan Ping, Yongming Chen.  (2023)  Direct Cytosolic Delivery of Proteins and CRISPR-Cas9 Genome Editing by Gemini Amphiphiles via Non-Endocytic Translocation Pathways.  ACS Central Science,      [PMID:37521791]
11. Wenjing Huang, Li Wang, Hao Zhang, Zhihao Han, Yueqing Gu.  (2023)  Near-infrared targeted EGFR fluorescent probe for tumor imaging and diagnosis.  SENSORS AND ACTUATORS B-CHEMICAL,  393  (134102).  [PMID:]
12. Ping Guan, Zhaoxu Meng, Xinran Liu, Jiaxiang Mu, Zichun Gao, Xinrong Yu, He Lian.  (2023)  A biomimetic mineralization nanosystem based on glycolysis-oxidative stress-autophagy regulation for the suppression of malignant tumor and lung metastasis.  CHEMICAL ENGINEERING JOURNAL,  468  (143730).  [PMID:]
13. Shengnan Huang, Chengzhi Song, Jinxin Miao, Xiali Zhu, Yongyan Jia, Yafei Liu, Dongjun Fu, Benyi Li, Mingsan Miao, Shaofeng Duan, Zhenzhong Zhang, Yurong Hu.  (2023)  Red blood cell membrane-coated functionalized Au nanocage as a biomimetic platform for improved MicroRNA delivery in hepatocellular carcinoma.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  642  (123044).  [PMID:37178790]
14. Jinhui Lu, Xiaomeng Zhu, Meng Zhang, Xunchan Jiang, Wei Guo, Feng Jiang, Feng Cao.  (2023)  In vitro and in vivo assessment of structural integrity for HPCD complex@Liposome nanocomposites from ocular surface to the posterior segment of the eye.  CARBOHYDRATE POLYMERS,  315  (120960).  [PMID:37230631]
15. Chang Ni, Zijun Zhang, Yuling Wang, Zhenhai Zhang, Xueping Guo, Huixia Lv.  (2023)  Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention.  JOURNAL OF CONTROLLED RELEASE,  357  (432).  [PMID:37004799]
16. Shi-Jie Hao, Ya-Xuan Zhu, Fu-Gen Wu.  (2023)  Membrane fusion-mediated delivery of small-molecule HER2 tyrosine kinase inhibitor for effective tumor chemosensitization.  JOURNAL OF CONTROLLED RELEASE,  357  (222).  [PMID:36958404]
17. Junwu Wei, Yuan Liu, Yingxin Li, Zhanlin Zhang, Jie Meng, Shuang Xie, Xiaohong Li.  (2023)  Photothermal Propelling and Pyroelectric Potential-Promoted Cell Internalization of Janus Nanoparticles and Pyroelectrodynamic Tumor Therapy.  Advanced Healthcare Materials,  12  (18): (2300338).  [PMID:36857737]
18. Yanzhi Xing, Yulong Xu, Yanna Lin, E Shuang, Han Leng, Jianhua Wang, Xuwei Chen.  (2023)  Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  640  (626).  [PMID:36889060]
19. Yuan Gao, Yingxi Zhang, Hong Xia, Yuqing Ren, Haibin Zhang, Siwen Huang, Meiju Li, Yongjun Wang, Heran Li, Hongzhuo Liu.  (2023)  Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy.  DRUG DELIVERY,  30  (1): (2183814).  [PMID:36843529]
20. Xufeng Yang, Yongrui Peng, Yu-e Wang, Yuxiu Zheng, Yiming He, Jiali Pan, Nan Liu, Yongxin Xu, Renhuan Ma, Junqiu Zhai, Yan Ma, Shixia Guan.  (2023)  Curcumae Rhizoma Exosomes-like nanoparticles loaded Astragalus components improve the absorption and enhance anti-tumor effect.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  81  (104274).  [PMID:]
21. Nini Xin, Dong Gao, Borui Su, Ting Zhou, Yuda Zhu, Chengheng Wu, Dan Wei, Jing Sun, Hongsong Fan.  (2023)  Orange-Emissive Carbon Dots with High Photostability for Mitochondrial Dynamics Tracking in Living Cells.  ACS Sensors,  (3): (1161–1172).  [PMID:36795996]
22. Zhanlin Zhang, Tian Xia, Pan Ran, Junwu Wei, Jie Meng, Guiyuan Zhang, Xiaohong Li.  (2023)  Persistent luminescence-activated Janus nanomotors with integration of photodynamic and photothermal cancer therapies.  CHEMICAL ENGINEERING JOURNAL,  457  (141226).  [PMID:]
23. Li Fangyuan, Sun Heng, Ren Jiafeng, Zhang Bo, Hu Xi, Fang Chunyan, Lee Jiyoung, Gu Hongzhou, Ling Daishun.  (2022)  A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance.  Nature Communications,  13  (1): (1-16).  [PMID:36450764]
24. Guo Yuxin, Wang Shao-Zhe, Zhang Xinping, Jia Hao-Ran, Zhu Ya-Xuan, Zhang Xiaodong, Gao Ge, Jiang Yao-Wen, Li Chengcheng, Chen Xiaokai, Wu Shun-Yu, Liu Yi, Wu Fu-Gen.  (2022)  In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses.  Nature Communications,  13  (1): (1-20).  [PMID:36319625]
25. Jie Yang, Xiuhua Pan, Jun Zhang, Siyu Ma, Jianeng Zhou, Zengguang Jia, Yawen Wei, Zengyi Liu, Ning Yang, Qi Shen.  (2022)  Reprogramming dysfunctional dendritic cells by a versatile metabolism nano-intervenor for enhancing cancer combinatorial immunotherapy.  Nano Today,  46  (101618).  [PMID:]
26. Yanyan Wang, Hai Gao, Xinya Huang, Zhaoan Chen, Pengyu Kang, Yunyi Zhou, Danhua Qin, Wenli Zhang, Jianping Liu.  (2022)  Cyclodextrin boostered-high density lipoprotein for antiatherosclerosis by regulating cholesterol efflux and efferocytosis.  CARBOHYDRATE POLYMERS,  292  (119632).  [PMID:35725197]
27. Jie Zhao, Fei Wu, Qiang He, Yawei Feng.  (2022)  Enhanced degradation of amiloride over Bi2FeNbO7/bisulfite process: Key factors and mechanism.  CHEMOSPHERE,  300  (134573).  [PMID:35436455]
28. Yu Zou, Quan Zhou, Yinan Zhao, Defu Zhi, Huiying Chen, Rui Wang, Benzhi Ju, Shubiao Zhang.  (2022)  Structure–activity relationships of pH-responsive and ionizable lipids for gene delivery.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,  617  (121596).  [PMID:35181463]
29. Lijuan Yang, Shaochi Liu, Tian Quan, Yongqing Tao, Meng Tian, Luchun Wang, Junji Wang, Dandan Wang, Die Gao.  (2022)  Sulfuric-acid-mediated synthesis strategy for multi-colour aggregation-induced emission fluorescent carbon dots: Application in anti-counterfeiting, information encryption, and rapid cytoplasmic imaging.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  612  (650).  [PMID:35030344]
30. Li Wu, Yan Shi, Zihui Ni, Tao Yu, Zhipeng Chen.  (2022)  Preparation of a Self-Assembled Rhein–Doxorubicin Nanogel Targeting Mitochondria and Investigation on Its Antihepatoma Activity.  MOLECULAR PHARMACEUTICS,  19  (1): (35–50).  [PMID:34890210]
31. Wenjie Feng, Wanrui Shi, Shuwei Liu, Huiwen Liu, Yi Liu, Pengfei Ge, Hao Zhang.  (2021)  Fe(III)-Shikonin Supramolecular Nanomedicine for Combined Therapy of Tumor via Ferroptosis and Necroptosis.  Advanced Healthcare Materials,  11  (2): (2101926).  [PMID:34738742]
32. Cuiping Jiang, Yuan Wang, Peiyi Liang, Yao Chen, Ziming Zhuang, Lu Zhang, Yankui Yi, Li Liu, Qiang Liu.  (2021)  ATP-Responsive Multifunctional Supramolecular Polymer as a Nonviral Vector for Boosting Cholesterol Removal from Lipid-Laden Macrophages.  ACS Biomaterials Science & Engineering,  (11): (5048–5063).  [PMID:34648280]
33. Haodong Cui, Min Jiang, Wenhua Zhou, Ming Gao, Rui He, Yifan Huang, Paul K. Chu, Xue-Feng Yu.  (2021)  Carrier-Free Cellular Transport of CRISPR/Cas9 Ribonucleoprotein for Genome Editing by Cold Atmospheric Plasma.  Biology-Basel,  10  (10): (1038).  [PMID:34681136]
34. Chi H, Gu Y, Xu T, Cao F.  (2017)  Multifunctional organic-inorganic hybrid nanoparticles and nanosheets based on chitosan derivative and layered double hydroxide: cellular uptake mechanism and application for topical ocular drug delivery..  Int J Nanomedicine,  12  (3): (1607-1620).  [PMID:28280329]
35. Xu T, Xu X, Gu Y, Fang L, Cao F.  (2018)  Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery..  Int J Nanomedicine,  13  (3): (917-937).  [PMID:29491707]
36. Wang Y, Zhou L, Fang L, Cao F.  (2020)  Multifunctional carboxymethyl chitosan derivatives-layered double hydroxide hybrid nanocomposites for efficient drug delivery to the posterior segment of the eye..  Acta Biomater,  104  (3): (104-114).  [PMID:31931169]
37. Kambere Amerigos Daddy J C,Minglei Chen,Faisal Raza,Yanyu Xiao,Zhigui Su,Qineng Ping.  (2020-02-28)  Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia..  Pharmaceutics,  12  ((2)):   [PMID:32102214]

Solution Calculators