Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A131615-1g | 1g | In stock | $172.90 | |
A131615-5g | 5g | In stock | $615.90 |
eNaC blocker
Synonyms | SPECTRUM1500112 | CAA01688 | CHEBI:84743 | NCGC00093608-01 | Amiloride hydrochloride (Midamor) | AMILORIDE HYDROCHLORIDE [MI] | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide hydrochloride | 3,5-diamino-N-[amino(imino)methyl]-6-chloropy |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).Epithelial sodium channel (eNaC) blocker. At higher concentrations, blocks the Na + /H+ exchange pathway. Also |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Amiloride ? HCl is a selective T-type calcium channel protein inhibitor that has been shown to inhibit the Polycystin-L channel (Polycystic kidney disease 2-like 1 protein: PKD2L1), a member of the transient receptor potential (TRP) superfamily of cation channels, including the NHE (sodium/hydgrogen exchanger). Amiloride is also an epithelial sodium channel protein inhibitor, which inhibits sodium reabsorption without affecting potassium concentrations. Amiloride serves as a non-selective acid-sensing ion channel (ASIC) blocker and a selective inhibitor of uPA (urokinase plasminogen activator). Research shows that amiloride reduces electrical potential across tubular epithelium, inhibits angiogenesis and inhibits capillary morphogenesis completely and reversibly at approximately 130 μM. Amiloride ? HCl is an inhibitor of Sodium/Potassium-ATPase Protein. |
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Pubchem Sid | 488182216 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488182216 |
IUPAC Name | 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide;hydrochloride |
INCHI | InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H |
InChi Key | ACHKKGDWZVCSNH-UHFFFAOYSA-N |
Canonical SMILES | C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl |
Isomeric SMILES | C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N.Cl |
RTECS | UQ2275500 |
PubChem CID | 16230 |
UN Number | 2811 |
Packing Group | I |
Molecular Weight | 266.09 |
Reaxy-Rn | 4038903 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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H2420050 | Certificate of Analysis | Aug 24, 2024 | A131615 |
A2405054 | Certificate of Analysis | Jan 09, 2024 | A131615 |
K2108783 | Certificate of Analysis | Aug 14, 2023 | A131615 |
C2304228 | Certificate of Analysis | Mar 31, 2023 | A131615 |
D2310197 | Certificate of Analysis | Jun 24, 2022 | A131615 |
I1416113 | Certificate of Analysis | Jun 24, 2022 | A131615 |
I2308216 | Certificate of Analysis | Jun 24, 2022 | A131615 |
Solubility | Soluble in DMSO (25 mg/ml), water (10 mM warm), and methanol. Insoluble in chloroform, and ethanol. |
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Melt Point(°C) | 299°C(lit.) |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H301:Toxic if swallowed H412:Harmful to aquatic life with long lasting effects |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
RTECS | UQ2275500 |
Reaxy-Rn | 4038903 |
Class | 6.1 |
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32. Chi H, Gu Y, Xu T, Cao F. (2017) Multifunctional organic-inorganic hybrid nanoparticles and nanosheets based on chitosan derivative and layered double hydroxide: cellular uptake mechanism and application for topical ocular drug delivery.. Int J Nanomedicine, 12 (3): (1607-1620). [PMID:28280329] |
33. Xu T, Xu X, Gu Y, Fang L, Cao F. (2018) Functional intercalated nanocomposites with chitosan-glutathione-glycylsarcosine and layered double hydroxides for topical ocular drug delivery.. Int J Nanomedicine, 13 (3): (917-937). [PMID:29491707] |
34. Wang Y, Zhou L, Fang L, Cao F. (2020) Multifunctional carboxymethyl chitosan derivatives-layered double hydroxide hybrid nanocomposites for efficient drug delivery to the posterior segment of the eye.. Acta Biomater, 104 (3): (104-114). [PMID:31931169] |
35. Kambere Amerigos Daddy J C,Minglei Chen,Faisal Raza,Yanyu Xiao,Zhigui Su,Qineng Ping. (2020-02-28) Co-Encapsulation of Mitoxantrone and β-Elemene in Solid Lipid Nanoparticles to Overcome Multidrug Resistance in Leukemia.. Pharmaceutics, 12 ((2)): [PMID:32102214] |
1. Shi JM et al.. (2020) Endocytosis Is a Key Mode of Interaction between Extracellular ß-Amyloid and the Cell Membrane.. Biophys J, 119 (6): (1078-1090). [PMID:32857960] |
2. Jullié D et al.. (2014) Recycling endosomes undergo rapid closure of a fusion pore on exocytosis in neuronal dendrites.. J Neurosci, 34 (33): (11106-18). [PMID:25122907] |
3. Li Meng, Panpan Zhao, Yucheng Jiang, Jiawen You, Zhiyan Xu, Kui Yu, Aldo R. Boccaccini, Kai Zheng, Junqing Ma. (2023) Extracellular and intracellular effects of bioactive glass nanoparticles on osteogenic differentiation of bone marrow mesenchymal stem cells and bone regeneration in zebrafish osteoporosis model. Acta Biomaterialia, [PMID:38040077] |
4. Tao Wanjun, Xie Pei, Huang Chengyuan, Wang Ying, Huang Yu, Yin Zongning. (2023) Construction of PLGA nanoparticles modified with RWrNM and DLPC and their application in acute rhinosinusitis. Drug Delivery and Translational Research, (1): (1-14). [PMID:37966678] |
5. Shui Ling Yi, Zi Ling Li, Yan Chun Gong, Xiang Yuan Xiong. (2023) Inhibiting Multidrug Resistance with Transferrin-Targeted Polymersomes through Optimization of Ligand Density. LANGMUIR, 39 (45): (15920–15931). [PMID:37922445] |
6. Gongxi Qiao, Xuming Pan, Mengyun He, Ruixi Peng, Xiangrong Huang, Cunpeng Nie, Jianhui Jiang, Xia Chu. (2023) An ultrathin Zn-based layered double hydroxides augment degradation of mutant p53 to improve tumor therapy. CHEMICAL ENGINEERING JOURNAL, 475 (13): (146449). [PMID:27619977] |
7. Jianbo Li, Yaru Xu, Jieke Zhang, Qinglian Li, Chenxu Wang, Zhe Wu, Weijing Yang, Meng Xu, Zhenzhong Zhang, Lei Wang, Jinjie Zhang. (2023) Bioinspired fine-tuning of the mechanical rigidity of SNEDDS for the efficient crossing of multiple gastrointestinal barriers. JOURNAL OF CONTROLLED RELEASE, 362 (170). [PMID:37625600] |
8. Mingqiao Li, Hedan Xu, Nan Zhao, Liangjun Zhang, Haihan Xia, Xiaoxun Zhang, Qiao Li, Min Liao, Qiong Pan, Zeng Yi, Jin Chai. (2023) Hepatocyte-targeted hyaluronic acid-polyethyleneimine conjugates for acute liver injury therapy by ROS elimination and inflammation modulation. MATERIALS & DESIGN, 233 (112212). [PMID:] |
9. Zhanlin Zhang, Hui Yan, Wenxiong Cao, Shuang Xie, Pan Ran, Kun Wei, Xiaohong Li. (2023) Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment. ACS Nano, [PMID:37515593] |
10. Zhicheng Le, Qi Pan, Zepeng He, Hong Liu, Yi Shi, Lixin Liu, Zhijia Liu, Yuan Ping, Yongming Chen. (2023) Direct Cytosolic Delivery of Proteins and CRISPR-Cas9 Genome Editing by Gemini Amphiphiles via Non-Endocytic Translocation Pathways. ACS Central Science, [PMID:37521791] |
11. Wenjing Huang, Li Wang, Hao Zhang, Zhihao Han, Yueqing Gu. (2023) Near-infrared targeted EGFR fluorescent probe for tumor imaging and diagnosis. SENSORS AND ACTUATORS B-CHEMICAL, 393 (134102). [PMID:] |
12. Ping Guan, Zhaoxu Meng, Xinran Liu, Jiaxiang Mu, Zichun Gao, Xinrong Yu, He Lian. (2023) A biomimetic mineralization nanosystem based on glycolysis-oxidative stress-autophagy regulation for the suppression of malignant tumor and lung metastasis. CHEMICAL ENGINEERING JOURNAL, 468 (143730). [PMID:] |
13. Shengnan Huang, Chengzhi Song, Jinxin Miao, Xiali Zhu, Yongyan Jia, Yafei Liu, Dongjun Fu, Benyi Li, Mingsan Miao, Shaofeng Duan, Zhenzhong Zhang, Yurong Hu. (2023) Red blood cell membrane-coated functionalized Au nanocage as a biomimetic platform for improved MicroRNA delivery in hepatocellular carcinoma. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 642 (123044). [PMID:37178790] |
14. Jinhui Lu, Xiaomeng Zhu, Meng Zhang, Xunchan Jiang, Wei Guo, Feng Jiang, Feng Cao. (2023) In vitro and in vivo assessment of structural integrity for HPCD complex@Liposome nanocomposites from ocular surface to the posterior segment of the eye. CARBOHYDRATE POLYMERS, 315 (120960). [PMID:37230631] |
15. Chang Ni, Zijun Zhang, Yuling Wang, Zhenhai Zhang, Xueping Guo, Huixia Lv. (2023) Hyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retention. JOURNAL OF CONTROLLED RELEASE, 357 (432). [PMID:37004799] |
16. Shi-Jie Hao, Ya-Xuan Zhu, Fu-Gen Wu. (2023) Membrane fusion-mediated delivery of small-molecule HER2 tyrosine kinase inhibitor for effective tumor chemosensitization. JOURNAL OF CONTROLLED RELEASE, 357 (222). [PMID:36958404] |
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