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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | aminoguanidine | Pimagedine | Hydrazinecarboximidamide | 79-17-4 | Guanyl hydrazine | Monoaminoguanidine | 2-aminoguanidine | Imino semicarbazide | Aminate base | Pimagedine [INN] | GUANIDINE, AMINO- | Hydrazinecarboximidamide(9CI) | 2-azanylguanidine | SCQ4EZQ113 | CHEMBL225304 | CHE |
|---|---|
| Specifications & Purity | Moligand™ |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | Inhibitor of Inducible NOS |
Associated Targets(Human)
AOC1 Tchem Amiloride-sensitive amine oxidase [copper-containing] (1 Activities)
NOS2 Tchem Nitric oxide synthase, inducible (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
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AKR1B1 Tclin Aldose reductase (1404 Activities)
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AOC1 Tchem Diamine oxidase (68 Activities)
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ALB Tchem Serum albumin (2651 Activities)
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NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
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NOS3 Tchem Nitric-oxide synthase, endothelial (1452 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
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DLD-1 (17511 Activities)
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HEK293 (82097 Activities)
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FEN1 Tchem Flap endonuclease 1 (12055 Activities)
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KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
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NOS1 Tchem Nitric oxide sythases; iNOS & nNOS (685 Activities)
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Zone of skin (8 Activities)
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Associated Targets(non-human)
DPP4 Dipeptidyl peptidase IV (11 Activities)
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Nos2 Nitric oxide synthase, inducible (3573 Activities)
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Hdac6 Histone deacetylase 6 (222 Activities)
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Zea mays (820 Activities)
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Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
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RAW (181 Activities)
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RAW264.7 (28094 Activities)
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BV-2 (3710 Activities)
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lef Anthrax lethal factor (7585 Activities)
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rep Replicase polyprotein 1ab (378 Activities)
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Gossypium hirsutum (233 Activities)
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Vitis vinifera (99 Activities)
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Cat Catalase (15 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mapt Microtubule-associated protein tau (6 Activities)
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FL5.12 (351 Activities)
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SARS-CoV-2 (38078 Activities)
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Names and Identifiers
| IUPAC Name | 2-aminoguanidine |
|---|---|
| INCHI | InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5) |
| InChi Key | HAMNKKUPIHEESI-UHFFFAOYSA-N |
| Canonical SMILES | C(=NN)(N)N |
| Isomeric SMILES | C(=NN)(N)N |
| Alternate CAS | 79-17-4,1937-19-5 (hydrochloride) |
| PubChem CID | 2146 |
| MeSH Entry Terms | aminoguanidine;aminoguanidine sulfate;hydrazinecarboximidamide;monoaminoguanidine;pimagedine;pimagedine hydrochloride |
Database links
| CAS Registry No. | 79-17-4 |
|---|---|
| DrugBank Ligand | DB02533 |
| Wikipedia | Aminoguanidine |
| ChEBI | CHEBI:40618 |
| PubChem CID | 2146 |
| ChEMBL Ligand | CHEMBL225304 |
| RCSB PDB Ligand | AGU |
Certificates
Certificate of Analysis(COA)
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Related Documents
Citations of This Product
| 1. Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. FOOD CHEMISTRY, 416 (135801). [PMID:36870150] |
| 2. Liu Mei, Sun Zhaomeng, Guo Rong. (2023) Selective and Sensitive Detection of Pseudomonas aeruginosa Based on Aminoguanidine-Functionalized Carbon Dots Synthesized by One-Step Hydrothermal Method. Food Analytical Methods, 16 (2): (377-385). [PMID:] |
| 3. Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai. (2022) Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3. EUROPEAN JOURNAL OF PHARMACOLOGY, 929 (175115). [PMID:35738453] |
| 4. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou. (2022) Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum. MOLECULES, 27 (5): (1457). [PMID:35268560] |
References
| 1. Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. FOOD CHEMISTRY, 416 (135801). [PMID:36870150] |
| 2. Liu Mei, Sun Zhaomeng, Guo Rong. (2023) Selective and Sensitive Detection of Pseudomonas aeruginosa Based on Aminoguanidine-Functionalized Carbon Dots Synthesized by One-Step Hydrothermal Method. Food Analytical Methods, 16 (2): (377-385). [PMID:] |
| 3. Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai. (2022) Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3. EUROPEAN JOURNAL OF PHARMACOLOGY, 929 (175115). [PMID:35738453] |
| 4. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou. (2022) Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum. MOLECULES, 27 (5): (1457). [PMID:35268560] |