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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | CCG-204198 | AB00443011_04 | PIMAGEDINE [MART.] | SR-01000075164-1 | W-104265 | Lopac0_000050 | Guanyl hydrazine | Hydrazinecarboximidamide(9CI) | NCGC00015082-02 | NCGC00015082-07 | AMY873 | GUANIDINE, AMINO- | FT-0693034 | Pimagedine | DB05383 | 2-azany |
|---|---|
| Specifications & Purity | Moligand™ |
| Grade | Moligand™ |
| Action Type | INHIBITOR |
| Mechanism of action | Inhibitor of Inducible NOS |
Associated Targets(Human)
AOC1 Tchem Amiloride-sensitive amine oxidase [copper-containing] (1 Activities)
NOS2 Tchem Nitric oxide synthase, inducible (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AKR1B1 Tclin Aldose reductase (1404 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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AOC1 Tchem Diamine oxidase (68 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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ALB Tchem Serum albumin (2651 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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NOS1 Tchem Nitric-oxide synthase, brain (1786 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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NOS3 Tchem Nitric-oxide synthase, endothelial (1452 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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DLD-1 (17511 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HEK293 (82097 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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FEN1 Tchem Flap endonuclease 1 (12055 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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KDM1A Tchem Lysine-specific histone demethylase 1 (3916 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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NOS1 Tchem Nitric oxide sythases; iNOS & nNOS (685 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Zone of skin (8 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Associated Targets(non-human)
DPP4 Dipeptidyl peptidase IV (11 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Nos2 Nitric oxide synthase, inducible (3573 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Hdac6 Histone deacetylase 6 (222 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Zea mays (820 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mus musculus (284745 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Rattus norvegicus (775804 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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RAW (181 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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RAW264.7 (28094 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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BV-2 (3710 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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lef Anthrax lethal factor (7585 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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rep Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Gossypium hirsutum (233 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Vitis vinifera (99 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Cat Catalase (15 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mapt Microtubule-associated protein tau (6 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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FL5.12 (351 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | 2-aminoguanidine |
|---|---|
| INCHI | InChI=1S/CH6N4/c2-1(3)5-4/h4H2,(H4,2,3,5) |
| InChi Key | HAMNKKUPIHEESI-UHFFFAOYSA-N |
| Canonical SMILES | C(=NN)(N)N |
| Isomeric SMILES | C(=NN)(N)N |
| Alternate CAS | 79-17-4,1937-19-5 (hydrochloride) |
| PubChem CID | 2146 |
| MeSH Entry Terms | aminoguanidine;aminoguanidine sulfate;hydrazinecarboximidamide;monoaminoguanidine;pimagedine;pimagedine hydrochloride |
Database links
| CAS Registry No. | 79-17-4 |
|---|---|
| DrugBank Ligand | DB02533 |
| Wikipedia | Aminoguanidine |
| ChEBI | CHEBI:40618 |
| PubChem CID | 2146 |
| ChEMBL Ligand | CHEMBL225304 |
| RCSB PDB Ligand | AGU |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Related Documents
Citations of This Product
| 1. Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. FOOD CHEMISTRY, 416 (135801). [PMID:36870150] [10.1016/j.foodchem.2023.135801] |
| 2. Liu Mei, Sun Zhaomeng, Guo Rong. (2023) Selective and Sensitive Detection of Pseudomonas aeruginosa Based on Aminoguanidine-Functionalized Carbon Dots Synthesized by One-Step Hydrothermal Method. Food Analytical Methods, 16 (2): (377-385). [PMID:] [10.1007/s12161-022-02424-x] |
| 3. Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai. (2022) Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3. EUROPEAN JOURNAL OF PHARMACOLOGY, 929 (175115). [PMID:35738453] [10.1016/j.ejphar.2022.175115] |
| 4. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou. (2022) Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum. MOLECULES, 27 (5): (1457). [PMID:35268560] [10.3390/molecules27051457] |
| 5. Xiaoyun Han, Chunyue Song, Xiaoxin Feng, Yanan Wang, Tingting Meng, Shichao Li, Yunlong Bai, Baochang Du, Qingshen Sun. (2020) Isolation and hypoglycemic effects of water extracts from mulberry leaves in Northeast China. Food & Function, 11 (4): (3112-3125). [PMID:32196541] [10.1039/D0FO00012D] |
| 6. Xiaqing Wu, Guowen Zhang, Mingming Hu, Junhui Pan, Ang Li, Ying Zhang. (2020) Molecular characteristics of gallocatechin gallate affecting protein glycation. FOOD HYDROCOLLOIDS, 105 (105782). [PMID:] [10.1016/j.foodhyd.2020.105782] |
| 7. Yue Liu, Zhuang-Zhuang Tang, Yu-Meng Zhang, Li Kong, Wei-Fen Xiao, Teng-Fei Ma, Yao-Wu Liu. (2020) Thrombin/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes. BIOCHEMICAL PHARMACOLOGY, 175 (113849). [PMID:32059841] [10.1016/j.bcp.2020.113849] |
| 8. Hengye Chen, Muhammad Safiullah Virk, Fusheng Chen. (2016) Phenolic acids inhibit the formation of advanced glycation end products in food simulation systems depending on their reducing powers and structures. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, [PMID:27102241] [10.3109/09637486.2016.1166187] |
| 9. Guang-Yue Hou, Lu Wang, Shu Liu, Feng-Rui Song, Zhi-Qiang Liu. (2014) Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity. CHINESE CHEMICAL LETTERS, 25 (1039). [PMID:] [10.1016/j.cclet.2014.04.029] |
References
| 1. Xi Peng, Xing Hu, Kai Liu, Deming Gong, Guowen Zhang. (2023) Exploring inhibitory effect and mechanism of hesperetin-Cu (II) complex against protein glycation. FOOD CHEMISTRY, 416 (135801). [PMID:36870150] [10.1016/j.foodchem.2023.135801] |
| 2. Liu Mei, Sun Zhaomeng, Guo Rong. (2023) Selective and Sensitive Detection of Pseudomonas aeruginosa Based on Aminoguanidine-Functionalized Carbon Dots Synthesized by One-Step Hydrothermal Method. Food Analytical Methods, 16 (2): (377-385). [PMID:] [10.1007/s12161-022-02424-x] |
| 3. Xin Zhao, Lingyu Li, Shuang Li, Jinyu Liu, Hongya Wang, Yulin Lin, Dayong Cai. (2022) Diammonium glycyrrhizinate ameliorates portal hypertension by regulating portal macrophage oxidation and superoxide dismutase 3. EUROPEAN JOURNAL OF PHARMACOLOGY, 929 (175115). [PMID:35738453] [10.1016/j.ejphar.2022.175115] |
| 4. Ying Zhang, Yanna Pan, Jiaqi Li, Zeng Zhang, Yanming He, Hongjie Yang, Ping Zhou. (2022) Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum. MOLECULES, 27 (5): (1457). [PMID:35268560] [10.3390/molecules27051457] |
| 5. Xiaoyun Han, Chunyue Song, Xiaoxin Feng, Yanan Wang, Tingting Meng, Shichao Li, Yunlong Bai, Baochang Du, Qingshen Sun. (2020) Isolation and hypoglycemic effects of water extracts from mulberry leaves in Northeast China. Food & Function, 11 (4): (3112-3125). [PMID:32196541] [10.1039/D0FO00012D] |
| 6. Xiaqing Wu, Guowen Zhang, Mingming Hu, Junhui Pan, Ang Li, Ying Zhang. (2020) Molecular characteristics of gallocatechin gallate affecting protein glycation. FOOD HYDROCOLLOIDS, 105 (105782). [PMID:] [10.1016/j.foodhyd.2020.105782] |
| 7. Yue Liu, Zhuang-Zhuang Tang, Yu-Meng Zhang, Li Kong, Wei-Fen Xiao, Teng-Fei Ma, Yao-Wu Liu. (2020) Thrombin/PAR-1 activation induces endothelial damages via NLRP1 inflammasome in gestational diabetes. BIOCHEMICAL PHARMACOLOGY, 175 (113849). [PMID:32059841] [10.1016/j.bcp.2020.113849] |
| 8. Hengye Chen, Muhammad Safiullah Virk, Fusheng Chen. (2016) Phenolic acids inhibit the formation of advanced glycation end products in food simulation systems depending on their reducing powers and structures. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, [PMID:27102241] [10.3109/09637486.2016.1166187] |
| 9. Guang-Yue Hou, Lu Wang, Shu Liu, Feng-Rui Song, Zhi-Qiang Liu. (2014) Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity. CHINESE CHEMICAL LETTERS, 25 (1039). [PMID:] [10.1016/j.cclet.2014.04.029] |