Aminoguanidine Hydrochloride - >98.0%(T), high purity , CAS No.1937-19-5

  • ≥98%(T)
Item Number
A151036
Grouped product items
SKUSizeAvailabilityPrice Qty
A151036-25g
25g
In stock
$39.90
A151036-100g
100g
In stock
$86.90
A151036-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$193.90

NOS inhibitor

Basic Description

SynonymsA813665 | DTXCID7024405 | SMR000875337 | SY057364 | Carbazamidine HCl | Aminoguanidine (hydrochloride) | Aminoguanidine monohydrochloride | HY-B1041 | W-107714 | Aminoguanidine HCl | CCG-213626 | AC8587 | AMINOGUANIDINE HYDROCHLORIDE [MI] | PIMAGEDINE HYD
Specifications & Purity≥98%(T)
Biochemical and Physiological MechanismsInhibits both constitutive and inducible nitric oxide synthetase. .Irreversible inhibitor of iNOS, displaying 26-fold selectivity over nNOS.
Storage TempArgon charged
Shipped InNormal
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Introduction

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Product Usage

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488192651
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488192651
IUPAC Name 2-aminoguanidine;hydrochloride
INCHI InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChi Key UBDZFAGVPPMTIT-UHFFFAOYSA-N
Canonical SMILES C(=NN)(N)N.Cl
Isomeric SMILES C(=NN)(N)N.Cl
WGK Germany 3
RTECS ME8430000
PubChem CID 2734687
UN Number 3077
Packing Group III
Molecular Weight 110.55
Reaxy-Rn 3909606

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
G2411189Certificate of AnalysisJun 12, 2024 A151036
H2401291Certificate of AnalysisJun 12, 2024 A151036
F2427097Certificate of AnalysisJun 12, 2024 A151036
H2328163Certificate of AnalysisAug 12, 2023 A151036
H2328164Certificate of AnalysisAug 12, 2023 A151036
H2328165Certificate of AnalysisAug 12, 2023 A151036
B2317192Certificate of AnalysisJan 04, 2023 A151036
B2317253Certificate of AnalysisJan 04, 2023 A151036
B2317278Certificate of AnalysisJan 04, 2023 A151036
B2317323Certificate of AnalysisJan 04, 2023 A151036
B2317324Certificate of AnalysisJan 04, 2023 A151036

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Chemical and Physical Properties

SolubilityDMSO (Slightly), Methanol (Slightly)
SensitivityAir & Moisture & heat & light sensitive
Melt Point(°C)162-166 °C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H411:Toxic to aquatic life with long lasting effects

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P501:Dispose of contents/container to ...

P272:Contaminated work clothing should not be allowed out of the workplace.

P362+P364:Take off contaminated clothing and wash it before reuse.

P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

WGK Germany 3
RTECS ME8430000
Reaxy-Rn 3909606
Class 9

Related Documents

Citations of This Product

1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang.  (2024)  Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies.  JOURNAL OF MOLECULAR STRUCTURE,  1296  (3): (136938).  [PMID:25527291] [10.1016/j.molstruc.2023.136938]
2. Weiming Chai, Qiuxia Pan, Qiuhan Bai, Yifeng Wu, Wenshuang Wei, Linjun Wang, Du Zhu.  (2023)  Condensed tannins from the leave of Dimocarpus longan Lour. exhibit anti-tyrosinase, anti-melanogenesis, anti-browning, anti-α-glucosidase, and anti-glycation activities.  INDUSTRIAL CROPS AND PRODUCTS,  206  (15): (117605).  [PMID:20551181] [10.1016/j.indcrop.2023.117605]
3. Qinhao Guan, Lihua Tang, Liangliang Zhang, Lixin Huang, Man Xu, Yuan Wang, Meng Zhang.  (2023)  Molecular insights into α-glucosidase inhibition and antiglycation properties affected by the galloyl moiety in (−)-epigallocatechin-3-gallate.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (15): (7381-7392).  [PMID:37390299] [10.1002/jsfa.12818]
4. Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang.  (2023)  Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity.  Molecular Therapy-Oncolytics,  29  (61-76).  [PMID:37223114] [10.1016/j.omto.2023.04.006]
5. Zhou Huiji, Zhou Luxian, Li Bo, Yue Rongcai.  (2023)  Anti-cyclooxygenase, anti-glycation, and anti-skin aging effect of Dendrobium officinale flowers’ aqueous extract and its phytochemical validation in aging.  Frontiers in Immunology,  14    [PMID:37006297] [10.3389/fimmu.2023.1095848]
6. Qinglu Li, Ruihua Tang, Hao Zhou, Xuxu Hu, Sufeng Zhang.  (2023)  A high-performance and flexible electrode film based on bacterial cellulose/polypyrrole/nitrogen-doped graphene for supercapacitors.  CARBOHYDRATE POLYMERS,  311  (120754).  [PMID:37028857] [10.1016/j.carbpol.2023.120754]
7. Changmei Lin, Honghui Zhao, Hai Huang, Xiaojuan Ma, Shilin Cao.  (2023)  PEO/cellulose composite paper based triboelectric nanogenerator and its application in human-health detection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  228  (251).  [PMID:36581021] [10.1016/j.ijbiomac.2022.12.237]
8. Chen Yu, Zi-Yi Yu, Yi-Ting Wen, Wei-Ming Chai, Lin-Jun Wang, Mei-Zhen Lin.  (2022)  Omeprazole inhibits α-glucosidase activity and the formation of nonenzymatic glycation products: Activity and mechanism.  JOURNAL OF BIOSCIENCE AND BIOENGINEERING,  133  (110).  [PMID:34802943] [10.1016/j.jbiosc.2021.10.007]
9. Xumin Xu, Hongyu Wei, Mingguang Liu, Laishui zhou, Guozhu Shen, Qin Li, Ghulam Hussain, Fan Yang, Reham Fathi, Haiji Chen, Kostya (Ken) Ostrikov.  (2021)  Nitrogen-doped carbon quantum dots for effective corrosion inhibition of Q235 steel in concentrated sulphuric acid solution.  Materials Today Communications,  29  (102872).  [PMID:] [10.1016/j.mtcomm.2021.102872]
10. Yishan Fu, Xiaojing Liu, Qian Ma, Junjie Yi, Shengbao Cai.  (2021)  Phytochemical bioaccessibility and in vitro antidiabetic effects of Chinese sumac (Rhus chinensis Mill.) fruits after a simulated digestion: insights into the mechanisms with molecular docking analysis.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  57  (5): (2656-2669).  [PMID:] [10.1111/ijfs.15238]
11. Jiangnan Zheng, Yuan Mao, Shun Feng, Ruijun Tian.  (2021)  Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned Medium†.  CHINESE JOURNAL OF CHEMISTRY,  39  (7): (1843-1848).  [PMID:] [10.1002/cjoc.202000752]
12. Shuang Song, Qing Liu, Wei-Ming Chai, Si-Shi Xia, Zi-Yi Yu, Qi-Ming Wei.  (2021)  Inhibitory potential of 4-hexylresorcinol against α-glucosidase and non-enzymatic glycation: Activity and mechanism.  JOURNAL OF BIOSCIENCE AND BIOENGINEERING,  131  (241).  [PMID:33191127] [10.1016/j.jbiosc.2020.10.011]
13. Halah Aalim, Di Wang, Zisheng Luo.  (2021)  Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.  FOOD RESEARCH INTERNATIONAL,  141  (109898).  [PMID:33641947] [10.1016/j.foodres.2020.109898]
14. Li Bo, Pan Yuanfeng, Zhang Qi, Huang Zhihong, Liu Jie, Xiao Huining.  (2019)  Porous cellulose beads reconstituted from ionic liquid for adsorption of heavy metal ions from aqueous solutions.  CELLULOSE,  26  (17): (9163-9178).  [PMID:] [10.1007/s10570-019-02687-4]
15. Halah Aalim, Tarun Belwal, Lei Jiang, Hao Huang, Xianghe Meng, Zisheng Luo.  (2019)  Extraction optimization, antidiabetic and antiglycation potentials of aqueous glycerol extract from rice (Oryza sativa L.) bran.  LWT-FOOD SCIENCE AND TECHNOLOGY,  103  (147).  [PMID:] [10.1016/j.lwt.2019.01.006]
16. Zhang Man, Li Chuan, Gao Huiqi, Fu Wei, Li Yingying, Tang Liwei, Zhou Zhiming.  (2016)  Promising hydrazinium 3-Nitro-1,2,4-triazol-5-one and its analogs.  JOURNAL OF MATERIALS SCIENCE,  51  (24): (10849-10862).  [PMID:] [10.1007/s10853-016-0296-7]

References

1. Skinner SC et al..  (2018)  Increased Prevalence of Type 2 Diabetes-Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait..  Diabetes Care,  41  (12): (2595-2602).  [PMID:30327363]
2. Zhang Q et al..  (2016)  Inhibition of cytoskeletal protein carbonylation may protect against oxidative damage in traumatic brain injury..  Exp Ther Med,  12  (6): (4107-4112).  [PMID:28101189]
3. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang.  (2024)  Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies.  JOURNAL OF MOLECULAR STRUCTURE,  1296  (3): (136938).  [PMID:25527291] [10.1016/j.molstruc.2023.136938]
4. Weiming Chai, Qiuxia Pan, Qiuhan Bai, Yifeng Wu, Wenshuang Wei, Linjun Wang, Du Zhu.  (2023)  Condensed tannins from the leave of Dimocarpus longan Lour. exhibit anti-tyrosinase, anti-melanogenesis, anti-browning, anti-α-glucosidase, and anti-glycation activities.  INDUSTRIAL CROPS AND PRODUCTS,  206  (15): (117605).  [PMID:20551181] [10.1016/j.indcrop.2023.117605]
5. Qinhao Guan, Lihua Tang, Liangliang Zhang, Lixin Huang, Man Xu, Yuan Wang, Meng Zhang.  (2023)  Molecular insights into α-glucosidase inhibition and antiglycation properties affected by the galloyl moiety in (−)-epigallocatechin-3-gallate.  JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE,  103  (15): (7381-7392).  [PMID:37390299] [10.1002/jsfa.12818]
6. Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang.  (2023)  Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity.  Molecular Therapy-Oncolytics,  29  (61-76).  [PMID:37223114] [10.1016/j.omto.2023.04.006]
7. Zhou Huiji, Zhou Luxian, Li Bo, Yue Rongcai.  (2023)  Anti-cyclooxygenase, anti-glycation, and anti-skin aging effect of Dendrobium officinale flowers’ aqueous extract and its phytochemical validation in aging.  Frontiers in Immunology,  14    [PMID:37006297] [10.3389/fimmu.2023.1095848]
8. Qinglu Li, Ruihua Tang, Hao Zhou, Xuxu Hu, Sufeng Zhang.  (2023)  A high-performance and flexible electrode film based on bacterial cellulose/polypyrrole/nitrogen-doped graphene for supercapacitors.  CARBOHYDRATE POLYMERS,  311  (120754).  [PMID:37028857] [10.1016/j.carbpol.2023.120754]
9. Changmei Lin, Honghui Zhao, Hai Huang, Xiaojuan Ma, Shilin Cao.  (2023)  PEO/cellulose composite paper based triboelectric nanogenerator and its application in human-health detection.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,  228  (251).  [PMID:36581021] [10.1016/j.ijbiomac.2022.12.237]
10. Chen Yu, Zi-Yi Yu, Yi-Ting Wen, Wei-Ming Chai, Lin-Jun Wang, Mei-Zhen Lin.  (2022)  Omeprazole inhibits α-glucosidase activity and the formation of nonenzymatic glycation products: Activity and mechanism.  JOURNAL OF BIOSCIENCE AND BIOENGINEERING,  133  (110).  [PMID:34802943] [10.1016/j.jbiosc.2021.10.007]
11. Xumin Xu, Hongyu Wei, Mingguang Liu, Laishui zhou, Guozhu Shen, Qin Li, Ghulam Hussain, Fan Yang, Reham Fathi, Haiji Chen, Kostya (Ken) Ostrikov.  (2021)  Nitrogen-doped carbon quantum dots for effective corrosion inhibition of Q235 steel in concentrated sulphuric acid solution.  Materials Today Communications,  29  (102872).  [PMID:] [10.1016/j.mtcomm.2021.102872]
12. Yishan Fu, Xiaojing Liu, Qian Ma, Junjie Yi, Shengbao Cai.  (2021)  Phytochemical bioaccessibility and in vitro antidiabetic effects of Chinese sumac (Rhus chinensis Mill.) fruits after a simulated digestion: insights into the mechanisms with molecular docking analysis.  INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY,  57  (5): (2656-2669).  [PMID:] [10.1111/ijfs.15238]
13. Jiangnan Zheng, Yuan Mao, Shun Feng, Ruijun Tian.  (2021)  Combining Metabolic Alkyne Labeling and Click Chemistry for Secretome Analysis of Serum-Containing Conditioned Medium†.  CHINESE JOURNAL OF CHEMISTRY,  39  (7): (1843-1848).  [PMID:] [10.1002/cjoc.202000752]
14. Shuang Song, Qing Liu, Wei-Ming Chai, Si-Shi Xia, Zi-Yi Yu, Qi-Ming Wei.  (2021)  Inhibitory potential of 4-hexylresorcinol against α-glucosidase and non-enzymatic glycation: Activity and mechanism.  JOURNAL OF BIOSCIENCE AND BIOENGINEERING,  131  (241).  [PMID:33191127] [10.1016/j.jbiosc.2020.10.011]
15. Halah Aalim, Di Wang, Zisheng Luo.  (2021)  Black rice (Oryza sativa L.) processing: Evaluation of physicochemical properties, in vitro starch digestibility, and phenolic functions linked to type 2 diabetes.  FOOD RESEARCH INTERNATIONAL,  141  (109898).  [PMID:33641947] [10.1016/j.foodres.2020.109898]
16. Li Bo, Pan Yuanfeng, Zhang Qi, Huang Zhihong, Liu Jie, Xiao Huining.  (2019)  Porous cellulose beads reconstituted from ionic liquid for adsorption of heavy metal ions from aqueous solutions.  CELLULOSE,  26  (17): (9163-9178).  [PMID:] [10.1007/s10570-019-02687-4]
17. Halah Aalim, Tarun Belwal, Lei Jiang, Hao Huang, Xianghe Meng, Zisheng Luo.  (2019)  Extraction optimization, antidiabetic and antiglycation potentials of aqueous glycerol extract from rice (Oryza sativa L.) bran.  LWT-FOOD SCIENCE AND TECHNOLOGY,  103  (147).  [PMID:] [10.1016/j.lwt.2019.01.006]
18. Zhang Man, Li Chuan, Gao Huiqi, Fu Wei, Li Yingying, Tang Liwei, Zhou Zhiming.  (2016)  Promising hydrazinium 3-Nitro-1,2,4-triazol-5-one and its analogs.  JOURNAL OF MATERIALS SCIENCE,  51  (24): (10849-10862).  [PMID:] [10.1007/s10853-016-0296-7]

Solution Calculators