Grouped product items

SKU

Size

Availability

Price

Qty

A151036-25g

25g

In stock

$39.90

A151036-100g

100g

In stock

$86.90

A151036-500g

500g

Available within 4-8 weeks(?)

$193.90

Basic Description

Synonyms

A813665 | DTXCID7024405 | SMR000875337 | SY057364 | Carbazamidine HCl | Aminoguanidine (hydrochloride) | Aminoguanidine monohydrochloride | HY-B1041 | W-107714 | Aminoguanidine HCl | CCG-213626 | AC8587 | AMINOGUANIDINE HYDROCHLORIDE [MI] | PIMAGEDINE HYD

Specifications & Purity

≥98%(T)

Biochemical and Physiological Mechanisms

Inhibits both constitutive and inducible nitric oxide synthetase. .Irreversible inhibitor of iNOS, displaying 26-fold selectivity over nNOS.

Storage Temp

Argon charged

Shipped In

Normal

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product Introduction

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Product Usage

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Associated Targets(Human)

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BLM Tchem Bloom syndrome protein (4248 Activities)

Discover Target: BLM

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)

Discover Target: ampC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488192651
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488192651
IUPAC Name	2-aminoguanidine;hydrochloride
INCHI	InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChi Key	UBDZFAGVPPMTIT-UHFFFAOYSA-N
Canonical SMILES	C(=NN)(N)N.Cl
Isomeric SMILES	C(=NN)(N)N.Cl
WGK Germany	3
RTECS	ME8430000
PubChem CID	2734687
UN Number	3077
Packing Group	III
Molecular Weight	110.55
Reaxy-Rn	3909606

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
G2411189	Certificate of Analysis	Jun 12, 2024	A151036
H2401291	Certificate of Analysis	Jun 12, 2024	A151036
F2427097	Certificate of Analysis	Jun 12, 2024	A151036
B2317253	Certificate of Analysis	Dec 21, 2023	A151036
H2328163	Certificate of Analysis	Aug 12, 2023	A151036
H2328164	Certificate of Analysis	Aug 12, 2023	A151036
H2328165	Certificate of Analysis	Aug 12, 2023	A151036
B2317192	Certificate of Analysis	Jan 04, 2023	A151036
B2317278	Certificate of Analysis	Jan 04, 2023	A151036
B2317323	Certificate of Analysis	Jan 04, 2023	A151036
B2317324	Certificate of Analysis	Jan 04, 2023	A151036

Show more⌵

Chemical and Physical Properties

Solubility	DMSO (Slightly), Methanol (Slightly)
Sensitivity	Air & Moisture & heat & light sensitive
Melt Point(°C)	162-166 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H411:Toxic to aquatic life with long lasting effects H317:May cause an allergic skin reaction
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P362+P364:Take off contaminated clothing and wash it before reuse. P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
WGK Germany	3
RTECS	ME8430000
Reaxy-Rn	3909606
Class	9

FAQs and Articles

FAQ

PANoptosis: An inflammatory programmed cell death pathway

Categories: Technical articles

Tags:

PAN apoptosis

Citations of This Product

1. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang. (2024) Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies. JOURNAL OF MOLECULAR STRUCTURE, 1296 (3): (136938). [PMID:25527291]
2. Weiming Chai, Qiuxia Pan, Qiuhan Bai, Yifeng Wu, Wenshuang Wei, Linjun Wang, Du Zhu. (2023) Condensed tannins from the leave of Dimocarpus longan Lour. exhibit anti-tyrosinase, anti-melanogenesis, anti-browning, anti-α-glucosidase, and anti-glycation activities. INDUSTRIAL CROPS AND PRODUCTS, 206 (15): (117605). [PMID:20551181]
3. Qinhao Guan, Lihua Tang, Liangliang Zhang, Lixin Huang, Man Xu, Yuan Wang, Meng Zhang. (2023) Molecular insights into α-glucosidase inhibition and antiglycation properties affected by the galloyl moiety in (−)-epigallocatechin-3-gallate. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (15): (7381-7392). [PMID:37390299]
4. Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang. (2023) Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity. Molecular Therapy-Oncolytics, 29 (61-76). [PMID:37223114]
5. Zhou Huiji, Zhou Luxian, Li Bo, Yue Rongcai. (2023) Anti-cyclooxygenase, anti-glycation, and anti-skin aging effect of Dendrobium officinale flowers’ aqueous extract and its phytochemical validation in aging. Frontiers in Immunology, 14 [PMID:37006297]
6. Qinglu Li, Ruihua Tang, Hao Zhou, Xuxu Hu, Sufeng Zhang. (2023) A high-performance and flexible electrode film based on bacterial cellulose/polypyrrole/nitrogen-doped graphene for supercapacitors. CARBOHYDRATE POLYMERS, 311 (120754). [PMID:37028857]
7. Changmei Lin, Honghui Zhao, Hai Huang, Xiaojuan Ma, Shilin Cao. (2023) PEO/cellulose composite paper based triboelectric nanogenerator and its application in human-health detection. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 228 (251). [PMID:36581021]
8. Chen Yu, Zi-Yi Yu, Yi-Ting Wen, Wei-Ming Chai, Lin-Jun Wang, Mei-Zhen Lin. (2022) Omeprazole inhibits α-glucosidase activity and the formation of nonenzymatic glycation products: Activity and mechanism. JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 133 (110). [PMID:34802943]
9. Xumin Xu, Hongyu Wei, Mingguang Liu, Laishui zhou, Guozhu Shen, Qin Li, Ghulam Hussain, Fan Yang, Reham Fathi, Haiji Chen, Kostya (Ken) Ostrikov. (2021) Nitrogen-doped carbon quantum dots for effective corrosion inhibition of Q235 steel in concentrated sulphuric acid solution. Materials Today Communications, 29 (102872). [PMID:]

References

1. Zhang Q et al.. (2016) Inhibition of cytoskeletal protein carbonylation may protect against oxidative damage in traumatic brain injury.. Exp Ther Med, 12 (6): (4107-4112). [PMID:28101189]
2. Skinner SC et al.. (2018) Increased Prevalence of Type 2 Diabetes-Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait.. Diabetes Care, 41 (12): (2595-2602). [PMID:30327363]
3. Hai-Xia Xu, Hui Chen, Zhong-Ping Yin, Qing-Feng Zhang. (2024) Piceid dicarboxylic acid esters as potent α-glucosidase inhibitors and antiglycation agents: Synthesis, spectroscopic and molecular docking studies. JOURNAL OF MOLECULAR STRUCTURE, 1296 (3): (136938). [PMID:25527291]
4. Weiming Chai, Qiuxia Pan, Qiuhan Bai, Yifeng Wu, Wenshuang Wei, Linjun Wang, Du Zhu. (2023) Condensed tannins from the leave of Dimocarpus longan Lour. exhibit anti-tyrosinase, anti-melanogenesis, anti-browning, anti-α-glucosidase, and anti-glycation activities. INDUSTRIAL CROPS AND PRODUCTS, 206 (15): (117605). [PMID:20551181]
5. Qinhao Guan, Lihua Tang, Liangliang Zhang, Lixin Huang, Man Xu, Yuan Wang, Meng Zhang. (2023) Molecular insights into α-glucosidase inhibition and antiglycation properties affected by the galloyl moiety in (−)-epigallocatechin-3-gallate. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 103 (15): (7381-7392). [PMID:37390299]
6. Jun Xie, Shaowei Wang, Yunhong Zhong, Ming Gao, Xuezhang Tian, Liting Zhang, Dongli Pan, Qingsong Qin, Bing Wu, Ke Lan, Zhi-Jun Sun, Junjie Zhang. (2023) Oncolytic herpes simplex virus armed with a bacterial GBP1 degrader improves antitumor activity. Molecular Therapy-Oncolytics, 29 (61-76). [PMID:37223114]
7. Zhou Huiji, Zhou Luxian, Li Bo, Yue Rongcai. (2023) Anti-cyclooxygenase, anti-glycation, and anti-skin aging effect of Dendrobium officinale flowers’ aqueous extract and its phytochemical validation in aging. Frontiers in Immunology, 14 [PMID:37006297]
8. Qinglu Li, Ruihua Tang, Hao Zhou, Xuxu Hu, Sufeng Zhang. (2023) A high-performance and flexible electrode film based on bacterial cellulose/polypyrrole/nitrogen-doped graphene for supercapacitors. CARBOHYDRATE POLYMERS, 311 (120754). [PMID:37028857]
9. Changmei Lin, Honghui Zhao, Hai Huang, Xiaojuan Ma, Shilin Cao. (2023) PEO/cellulose composite paper based triboelectric nanogenerator and its application in human-health detection. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 228 (251). [PMID:36581021]
10. Chen Yu, Zi-Yi Yu, Yi-Ting Wen, Wei-Ming Chai, Lin-Jun Wang, Mei-Zhen Lin. (2022) Omeprazole inhibits α-glucosidase activity and the formation of nonenzymatic glycation products: Activity and mechanism. JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 133 (110). [PMID:34802943]
11. Xumin Xu, Hongyu Wei, Mingguang Liu, Laishui zhou, Guozhu Shen, Qin Li, Ghulam Hussain, Fan Yang, Reham Fathi, Haiji Chen, Kostya (Ken) Ostrikov. (2021) Nitrogen-doped carbon quantum dots for effective corrosion inhibition of Q235 steel in concentrated sulphuric acid solution. Materials Today Communications, 29 (102872). [PMID:]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.

Aminoguanidine Hydrochloride - >98.0%(T), high purity , CAS No.1937-19-5