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Aminoguanidine Hydrochloride - >98.0%(T), high purity , CAS No.1937-19-5

  • ≥98%(T)
Item Number
A151036
Grouped product items
SKUSizeAvailabilityPrice Qty
A151036-25g
25g
In stock
$39.90
A151036-100g
100g
In stock
$86.90
A151036-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$193.90

NOS inhibitor

Basic Description

SynonymsAminoguanidine hydrochloride|1937-19-5|16139-18-7|Pimagedine hydrochloride|Pimagedine HCl|Hydrazinecarboximidamide, monohydrochloride|Aminoguanidine HCl|Carbazamidine hydrochloride|Hydrazinecarboximidamide hydrochloride|Guanylhydrazine hydrochloride|1-ami
Specifications & Purity≥98%(T)
Biochemical and Physiological MechanismsInhibits both constitutive and inducible nitric oxide synthetase. .Irreversible inhibitor of iNOS, displaying 26-fold selectivity over nNOS.
Storage TempArgon charged
Shipped InNormal
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Introduction

Aminoguanidine hydrochloride has been reported in a study as inhibitor of animal nitric oxide (NO)-synthase. Crystal structure of aminoguanidine hydrochloride has been investigated by Fourier and least squares method. Its crystals were monoclinic and the guanidine part of the aminoguanidinium ion is planar.

Product Usage

Aminoguanidine hydrochloride may be employed as nitric oxide synthase (NOS) inhibitor to investigate its effect on the reduction of alveolar bone loss in ligature induced periodontitis in rats. It may be used in the synthesis of 5-guanylhydrazone derivatives, having antibacterial activity against antibacterial activity against both Escherichia coli and Staphylococcus aureus.

Associated Targets

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CBX1 Tbio Chromobox protein homolog 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GMNN Tbio Geminin 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488192651
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488192651
IUPAC Name 2-aminoguanidine;hydrochloride
INCHI InChI=1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChi Key UBDZFAGVPPMTIT-UHFFFAOYSA-N
Canonical SMILES C(=NN)(N)N.Cl
Isomeric SMILES C(=NN)(N)N.Cl
WGK Germany 3
RTECS ME8430000
PubChem CID 2734687
UN Number 3077
Packing Group III
Molecular Weight 110.55
Reaxy-Rn 3909606

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot NumberCertificate TypeDateItem
G2411189Certificate of AnalysisJun 12, 2024 A151036
H2401291Certificate of AnalysisJun 12, 2024 A151036
F2427097Certificate of AnalysisJun 12, 2024 A151036
B2317253Certificate of AnalysisDec 21, 2023 A151036
H2328163Certificate of AnalysisAug 12, 2023 A151036
H2328164Certificate of AnalysisAug 12, 2023 A151036
H2328165Certificate of AnalysisAug 12, 2023 A151036
B2317192Certificate of AnalysisJan 04, 2023 A151036
B2317278Certificate of AnalysisJan 04, 2023 A151036
B2317323Certificate of AnalysisJan 04, 2023 A151036
B2317324Certificate of AnalysisJan 04, 2023 A151036

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Chemical and Physical Properties

SolubilityDMSO (Slightly), Methanol (Slightly)
SensitivityAir & Moisture & heat & light sensitive
Melt Point(°C)162-166 °C

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H411:Toxic to aquatic life with long lasting effects

H317:May cause an allergic skin reaction

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P501:Dispose of contents/container to ...

P272:Contaminated work clothing should not be allowed out of the workplace.

P362+P364:Take off contaminated clothing and wash it before reuse.

P332+P313:IF SKIN irritation occurs: Get medical advice/attention.

WGK Germany 3
RTECS ME8430000
Reaxy-Rn 3909606
Class 9

Related Documents

References

1. Zhang Q et al..  (2016)  Inhibition of cytoskeletal protein carbonylation may protect against oxidative damage in traumatic brain injury..  Exp Ther Med,  12  (6): (4107-4112).  [PMID:28101189]
2. Skinner SC et al..  (2018)  Increased Prevalence of Type 2 Diabetes-Related Complications in Combined Type 2 Diabetes and Sickle Cell Trait..  Diabetes Care,  41  (12): (2595-2602).  [PMID:30327363]

Solution Calculators