Aminopurvalanol A - ≥99%, high purity , CAS No.220792-57-4, Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5

Item Number

A274969

• Synonyms: 2-{[6-(3-Amino-5-chloroanilino)-9-(propan-2-yl)-1,9-dihydro-2H-purin-2-ylidene]amino}-3-methylbutan-1-ol | NCGC00025348-01 | CHEBI:38937 | (R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl- | aminopurvalanol A | GTPL5927 | SR-01000597531-1 | VIA79257
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: Potent, cell-permeable cyclin-dependent kinase inhibitor (IC 50 values are 33 (cdk1/cyclin B), 33 (cdk2/cyclin A), 28 (cdk2/cyclin E) and 20 nM (cdk5/p35)). Inhibits ERK1 (IC 50 = 12.0 μM) and ERK2 (IC 50 = 3.1 μM). Induces cell cycle arrest at G2/M phase
• Storage Temp: Protected from light,Store at -20°C,Argon charged
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of cyclin dependent kinase 1;Inhibitor of cyclin dependent kinase 2;Inhibitor of cyclin dependent kinase 5
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product description:

Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization.