Amiodarone hydrochloride - ≥98%, high purity , HERG blocker, CAS No.19774-82-4, HERG blocker

Item Number

A129574

Grouped product items
SKU	Size	Availability	Price
A129574-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$20.90
A129574-1g	1g	In stock	$64.90
A129574-5g	5g	In stock	$116.90
A129574-25g	25g	In stock	$526.90
A129574-100g	100g	In stock	$1,895.90

Broad-spectrum ion channel blocker. Antiarrhythmic agent.

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Basic Description

Synonyms	Amiodarone hydrochloride\|19774-82-4\|Amiodarone HCL\|Nexterone\|Amiodar\|Ritmocardyl\|Pacerone\|Trangorex\|Amiodarone (hydrochloride)\|Angoron\|Atlansil\|Cordarex\|Miodaron\|Miodrone\|Renodoron\|Rythmarone\|Amiodaronum hydrochloride\|Ancaron\|Ortacrone\|L 3428 labaz\|51087
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Action Type	BLOCKER
Mechanism of action	HERG blocker
Product Description	An inhibitor of 1,4-dihydropyridine binding to L-type Ca2+ channels

Names and Identifiers

Pubchem Sid	488189777
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488189777
IUPAC Name	(2-butyl-1-benzofuran-3-yl)-[4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl]methanone;hydrochloride
INCHI	InChI=1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
InChi Key	ITPDYQOUSLNIHG-UHFFFAOYSA-N
Canonical SMILES	CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl
Isomeric SMILES	CCCCC1=C(C2=CC=CC=C2O1)C(=O)C3=CC(=C(C(=C3)I)OCCN(CC)CC)I.Cl
WGK Germany	3
RTECS	OB1361000
PubChem CID	441325
Molecular Weight	681.77

Certificates

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10 results found

Lot Number	Certificate Type	Date	Item
I2209121	Certificate of Analysis	May 31, 2024	A129574
I2209128	Certificate of Analysis	May 31, 2024	A129574
I2209277	Certificate of Analysis	May 31, 2024	A129574
I2209278	Certificate of Analysis	May 31, 2024	A129574
L1525060	Certificate of Analysis	May 11, 2023	A129574
C2304013	Certificate of Analysis	Mar 14, 2023	A129574
C23031364	Certificate of Analysis	Mar 14, 2023	A129574
C23031319	Certificate of Analysis	Mar 13, 2023	A129574
E2406023	Certificate of Analysis	Jul 20, 2022	A129574
E2027103	Certificate of Analysis	Apr 22, 2022	A129574

Chemical and Physical Properties

Solubility	Soluble in water , chloroform ,dichloromethane,methanol ,DMSO (50 mM), ethanol , benzene , tetrahydrofuran , acetonitrile ,1-octanol ,ether,1-propanol, hexane ,petroleum ether ,iso-propanol (slight soluble), acetone (slight soluble), dioxane(slight solubl
Sensitivity	Light & Heat sensitive
Melt Point(°C)	156-163°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H373:Causes damage to organs through prolonged or repeated exposure H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P260:Do not breathe dust/fume/gas/mist/vapors/spray. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P317:Get emergency medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	OB1361000
Merck Index	482

References

1. Si L et al.. (2021) A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.. Nat Biomed Eng, 5 (8): (815-829). [PMID:33941899]
2. Ruparelia AA et al.. (2021) Metformin rescues muscle function in BAG3 myofibrillar myopathy models.. Autophagy, 17 (9): (2494-2510). [PMID:33030392]

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Basic Description