| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| A424342-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Histamine Receptor Inhibitors
| Synonyms | amitriptyline | 50-48-6 | Damitriptyline | Amitriptylin | Triptanol | Flavyl | Seroten | Proheptadiene | Elavil | Lantron | Triptisol | Tryptanol | Adepress | Adepril | Damilen | Amitryptiline | Triptilin | Redomex | Amitriprolidine | Laroxyl | Amytriptylin | Amitriptilina | Amitriptylinum | Amitrypt |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter ( |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | Information Amitriptyline Amitriptyline (MK-230, N-750, Ro41575) is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Amitriptyline is an inhibitor of both serotonin transporter (SERT) and norepinephrine transporter (NET) with Ki of 3.45 nM and 13.3 nM, respectively. Amitriptyline also inhibits histamine receptor H1 , histamine receptor H4 , 5-HT2 and sigma 1 receptor with Ki of 0.5 nM, 7.31 nM, 235 nM and 287 nM, respectively. This product is a waxy solid. |
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| IUPAC Name | N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine |
|---|---|
| INCHI | InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 |
| InChi Key | KRMDCWKBEZIMAB-UHFFFAOYSA-N |
| Canonical SMILES | CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
| Isomeric SMILES | CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31 |
| PubChem CID | 2160 |
| Molecular Weight | 277.41 |
Enter Lot Number to search for COA:
| Pictogram(s) | GHS06, GHS08, GHS09, GHS05, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H302:Harmful if swallowed H318:Causes serious eye damage H410:Very toxic to aquatic life with long lasting effects H361:Suspected of damaging fertility or the unborn child H301+H311+H331:Toxic if swallowed, in contact with skin or if inhaled |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P391:Collect spillage. P330:Rinse mouth. P361+P364:Take off immediately all contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P316:Get emergency medical help immediately. |
| 1. Yujie Cao, Tianran Sheng, Jinfei Mei, Peng Qian, Deqian Huang, Liangquan Sheng, Guoping Sheng. (2022) Abundant oxygen vacancies constructed by deep reduction strategy to achieve ultra-high peroxomonosulfate activation efficiency for degrading organic pollutions in water. APPLIED CATALYSIS B-ENVIRONMENTAL, 319 (121892). [PMID:] [10.1016/j.apcatb.2022.121892] |
| 2. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] [10.1039/C7RA10376J] |
| 3. Pengchao Xie, Yizhou Guo, Yiqun Chen, Zongping Wang, Ran Shang, Songlin Wang, Jiaqi Ding, Ying Wan, Wei Jiang, Jun Ma. (2017) Application of a novel advanced oxidation process using sulfite and zero-valent iron in treatment of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 314 (240). [PMID:] [10.1016/j.cej.2016.12.094] |
| 1. Yujie Cao, Tianran Sheng, Jinfei Mei, Peng Qian, Deqian Huang, Liangquan Sheng, Guoping Sheng. (2022) Abundant oxygen vacancies constructed by deep reduction strategy to achieve ultra-high peroxomonosulfate activation efficiency for degrading organic pollutions in water. APPLIED CATALYSIS B-ENVIRONMENTAL, 319 (121892). [PMID:] [10.1016/j.apcatb.2022.121892] |
| 2. Zhihong Yao, Shishi Li, Zifei Qin, Xiaodan Hong, Yi Dai, Baojian Wu, Wencai Ye, Frank J. Gonzalez, Xinsheng Yao. (2017) Characterization of human UDP-glucuronosyltransferases responsible for glucuronidation and inhibition of norbakuchinic acid, a primary metabolite of hepatotoxicity and nephrotoxicity component bakuchiol in Psoralea corylifolia L.. RSC Advances, 7 (83): (52661-52671). [PMID:] [10.1039/C7RA10376J] |
| 3. Pengchao Xie, Yizhou Guo, Yiqun Chen, Zongping Wang, Ran Shang, Songlin Wang, Jiaqi Ding, Ying Wan, Wei Jiang, Jun Ma. (2017) Application of a novel advanced oxidation process using sulfite and zero-valent iron in treatment of organic pollutants. CHEMICAL ENGINEERING JOURNAL, 314 (240). [PMID:] [10.1016/j.cej.2016.12.094] |
