Skip to the beginning of the images gallery

Amlodipine - 98%, high purity , CAS No.88150-42-9, Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Allosteric modulator of P2X4

Moligand™
≥98%

CAS#: 88150-42-9
Formula: C₂₀H₂₅ClN₂O₅
Molecular Weight: 408.88
MDL number: MFCD00887594
PubChem CID: 2162
PubChem SID: 488179669

Item Number

A123260

Grouped product items
SKU	Size	Availability	Price
A123260-1g	1g	In stock	$90.90
A123260-5g	5g	In stock	$286.90
A123260-10g	10g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$516.90
A123260-25g	25g	In stock	$1,162.90
A123260-100g	100g	In stock	$4,184.90

Potent, long-acting L-type calcium channel blocker

View related series

Cav1.2 Gating inhibitor Cav1.3 Gating inhibitor P2X4 Allosteric modulator

Basic Description

Synonyms	amlodipine\|88150-42-9\|Norvasc\|Amlocard\|Coroval\|Lipinox\|Amlodipino\|Amlodipinum\|Amlodipine Free Base\|AMLODIPINE BASE\|Caduet\|Istin\|Amlodipinum [Latin]\|CHEBI:2668\|3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-d
Specifications & Purity	98%
Storage Temp	Store at -20°C
Shipped In	Dry ice
Grade	Moligand™
Action Type	ALLOSTERIC MODULATOR, GATING INHIBITOR
Mechanism of action	Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Allosteric modulator of P2X4
Product Description	A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

Associated Targets

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 2 Activities

Discover Target: CACNA1C

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D 1 Activities

Discover Target: CACNA1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNK2 Tclin Potassium channel subfamily K member 2 1 Activities

Discover Target: KCNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

P2RX4 Tchem P2X purinoceptor 4 0 Activities

Discover Target: P2RX4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488179669
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179669
IUPAC Name	3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
INCHI	InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
InChi Key	HTIQEAQVCYTUBX-UHFFFAOYSA-N
Canonical SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
Isomeric SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
PubChem CID	2162
Molecular Weight	408.88

Database links

PubChem CID	2162
DrugBank Ligand	DB00381
Wikipedia	Amlodipine
CAS Registry No.	88150-42-9
ChEMBL Ligand	CHEMBL1491
PEP	amlodipine
DrugCentral Ligand	183
PubChem SID	488179669

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

10 results found

Lot Number	Certificate Type	Date	Item
I2318165	Certificate of Analysis	Sep 25, 2023	A123260
H2309517	Certificate of Analysis	Aug 17, 2023	A123260
J1921140	Certificate of Analysis	Aug 04, 2023	A123260
C2302442	Certificate of Analysis	Mar 15, 2023	A123260
C2302447	Certificate of Analysis	Mar 06, 2023	A123260
C2302443	Certificate of Analysis	Mar 06, 2023	A123260
B2428140	Certificate of Analysis	Jul 21, 2022	A123260
H2217132	Certificate of Analysis	Jul 21, 2022	A123260
H2217133	Certificate of Analysis	Jul 21, 2022	A123260
H2217134	Certificate of Analysis	Jul 21, 2022	A123260

Chemical and Physical Properties

Solubility	Soluble in dimethyl sulfoxide, ethanol, water, dimethyl formamide, acetone, chloroform, ethyl acetate and methanol.Water solubility:75.3 mg/L
Melt Point(°C)	178-179 ºC

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS09, GHS05
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H373:Causes damage to organs through prolonged or repeated exposure H318:Causes serious eye damage H400:Very toxic to aquatic life H410:Very toxic to aquatic life with long lasting effects
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P319:Get medical help if you feel unwell.

References

1. Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP et al.. (2014) International union of basic and clinical pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.. Pharmacol Rev, 66 (4): (918-47). [PMID:25026896]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.