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Amlodipine - 98%, high purity , CAS No.88150-42-9, Gating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Allosteric modulator of P2X4

8 Citations
Item Number
A123260
Grouped product items
SKUSizeAvailabilityPrice Qty
A123260-1g
1g
In stock
$90.90
A123260-5g
5g
In stock
$286.90
A123260-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$516.90
A123260-25g
25g
In stock
$1,162.90
A123260-100g
100g
In stock
$4,184.90
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Potent, long-acting L-type calcium channel blocker

View related series
Calcium Channel Cav1.2 Gating inhibitor Cav1.3 Gating inhibitor Membrane Transporter/Ion Channel Neuronal Signaling P2X4 Allosteric modulator

Basic Description

Synonyms88150-42-9 (free base) | 3-Ethyl-5-methyl (+-)-2-((2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate | AMLODIPINE (MART.) | BDBM50088383 | NCGC00165957-02 | Norvasc (TN) | 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-3-e
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsPotent, long-acting L-type calcium channel blocker (IC 50 =1.9 nM). Also stimulates nitric oxide synthase (NOS), lowers blood pressure and has antioxidant properties.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR, GATING INHIBITOR
Mechanism of actionGating inhibitor of Ca v1.2;Gating inhibitor of Ca v1.3;Allosteric modulator of P2X4
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

Associated Targets(Human)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CACNA1D Tclin Voltage-dependent L-type calcium channel subunit alpha-1D (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNK2 Tclin Potassium channel subfamily K member 2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
P2RX4 Tchem P2X purinoceptor 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488179669
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488179669
IUPAC Name 3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
INCHI InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3
InChi Key HTIQEAQVCYTUBX-UHFFFAOYSA-N
Canonical SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
Isomeric SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
PubChem CID 2162
Molecular Weight 408.88

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
I2318165Certificate of AnalysisSep 25, 2023 A123260
H2309517Certificate of AnalysisAug 17, 2023 A123260
J1921140Certificate of AnalysisAug 04, 2023 A123260
C2302442Certificate of AnalysisMar 15, 2023 A123260
C2302447Certificate of AnalysisMar 06, 2023 A123260
C2302443Certificate of AnalysisMar 06, 2023 A123260
B2428140Certificate of AnalysisJul 21, 2022 A123260
H2217132Certificate of AnalysisJul 21, 2022 A123260
H2217133Certificate of AnalysisJul 21, 2022 A123260
H2217134Certificate of AnalysisJul 21, 2022 A123260
J2421296Certificate of AnalysisJul 21, 2022 A123260

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Chemical and Physical Properties

SolubilitySoluble in dimethyl sulfoxide, ethanol, water, dimethyl formamide, acetone, chloroform, ethyl acetate and methanol.Water solubility:75.3 mg/L
Melt Point(°C)178-179 ºC

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS09,   GHS05
Signal Danger
Hazard Statements

H301:Toxic if swallowed

H373:Causes damage to organs through prolonged or repeated exposure

H318:Causes serious eye damage

H400:Very toxic to aquatic life

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P330:Rinse mouth.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing.

P317:Get emergency medical help.

P319:Get medical help if you feel unwell.

Related Documents

 SDS

 Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Chehao Lee, Guang Xin, Fan Li, Chengyu Wan, Xiuxian Yu, Lijuan Feng, Ao Wen, Yu Cao, Wen Huang.  (2023)  Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (14): (11554).  [PMID:37511311] [10.3390/ijms241411554]
2. Ruike Song, Yanxia Li, Yiting Chen, Zhenli Qiu, Lu Huang.  (2023)  Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations.  JOURNAL OF SEPARATION SCIENCE,  46  (8): (2201039).  [PMID:36750206] [10.1002/jssc.202201039]
3. Zhimin Gong, Gaobo Wang, Shuai Shao, Mengjie Wang, Kun Lu, Shixiang Gao.  (2022)  Co-degradation of coexisting pollutants methylparaben (mediators) and amlodipine in enzyme-mediator systems: Insight into the mediating mechanism.  JOURNAL OF HAZARDOUS MATERIALS,  423  (127112).  [PMID:34523479] [10.1016/j.jhazmat.2021.127112]
4. Zhu-Jun Zhong, Zhong-Ping Yao, Zi-Qi Shi, Yang-Dan Liu, Li-Fang Liu, Gui-Zhong Xin.  (2021)  Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach.  ANALYTICAL CHEMISTRY,  93  (24): (8536–8543).  [PMID:34107211] [10.1021/acs.analchem.1c01259]
5. Yujie Zhang, Hui Zhong, Shouyong Zhou, Haifeng Han, Mingliang Zhang, Hongdeng Qiu.  (2021)  A docosyl-terminated polyamine amphiphile-bonded stationary phase for multimodal separations in liquid chromatography.  JOURNAL OF CHROMATOGRAPHY A,  1642  (462045).  [PMID:33735643] [10.1016/j.chroma.2021.462045]
6. Lelin Zeng, Qin Yi, Qian Liu, Kewen Tang, Bart Van der Bruggen.  (2021)  Development of a new method and device for chiral drug enrichment and enantioseparation: Multiple-phase extraction and in situ coupling of crystallization.  SEPARATION AND PURIFICATION TECHNOLOGY,  257  (117884).  [PMID:] [10.1016/j.seppur.2020.117884]
7. Lelin Zeng, Qian Liu, Bart Van der Bruggen, Kewen Tang, Xiang Yi, Guoxiang Wang.  (2020)  An integrated separation process for recovery and enantioseparation of amlodipine from wastewater: Supported liquid membrane-aqueous/organic phase crystallization.  SEPARATION AND PURIFICATION TECHNOLOGY,  248  (117121).  [PMID:] [10.1016/j.seppur.2020.117121]
8. Shuai Shao, Li Qian, Xin Zhan, Mengjie Wang, Kun Lu, Jianbiao Peng, Dong Miao, Shixiang Gao.  (2020)  Transformation and toxicity evolution of amlodipine mediated by cobalt ferrite activated peroxymonosulfate: Effect of oxidant concentration.  CHEMICAL ENGINEERING JOURNAL,  382  (123005).  [PMID:] [10.1016/j.cej.2019.123005]

References

1. Christopoulos A, Changeux JP, Catterall WA, Fabbro D, Burris TP, Cidlowski JA, Olsen RW, Peters JA, Neubig RR, Pin JP et al..  (2014)  International union of basic and clinical pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands..  Pharmacol Rev,  66  (4): (918-47).  [PMID:25026896] [10.1021/op500134e]
2. Chehao Lee, Guang Xin, Fan Li, Chengyu Wan, Xiuxian Yu, Lijuan Feng, Ao Wen, Yu Cao, Wen Huang.  (2023)  Calcium/P53/Ninjurin 1 Signaling Mediates Plasma Membrane Rupture of Acinar Cells in Severe Acute Pancreatitis.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,  24  (14): (11554).  [PMID:37511311] [10.3390/ijms241411554]
3. Ruike Song, Yanxia Li, Yiting Chen, Zhenli Qiu, Lu Huang.  (2023)  Chiral covalent organic framework incorporated organic polymer monolithic capillary column for enantioseparations.  JOURNAL OF SEPARATION SCIENCE,  46  (8): (2201039).  [PMID:36750206] [10.1002/jssc.202201039]
4. Zhimin Gong, Gaobo Wang, Shuai Shao, Mengjie Wang, Kun Lu, Shixiang Gao.  (2022)  Co-degradation of coexisting pollutants methylparaben (mediators) and amlodipine in enzyme-mediator systems: Insight into the mediating mechanism.  JOURNAL OF HAZARDOUS MATERIALS,  423  (127112).  [PMID:34523479] [10.1016/j.jhazmat.2021.127112]
5. Zhu-Jun Zhong, Zhong-Ping Yao, Zi-Qi Shi, Yang-Dan Liu, Li-Fang Liu, Gui-Zhong Xin.  (2021)  Measurement of Intracellular Nitric Oxide with a Quantitative Mass Spectrometry Probe Approach.  ANALYTICAL CHEMISTRY,  93  (24): (8536–8543).  [PMID:34107211] [10.1021/acs.analchem.1c01259]
6. Yujie Zhang, Hui Zhong, Shouyong Zhou, Haifeng Han, Mingliang Zhang, Hongdeng Qiu.  (2021)  A docosyl-terminated polyamine amphiphile-bonded stationary phase for multimodal separations in liquid chromatography.  JOURNAL OF CHROMATOGRAPHY A,  1642  (462045).  [PMID:33735643] [10.1016/j.chroma.2021.462045]
7. Lelin Zeng, Qin Yi, Qian Liu, Kewen Tang, Bart Van der Bruggen.  (2021)  Development of a new method and device for chiral drug enrichment and enantioseparation: Multiple-phase extraction and in situ coupling of crystallization.  SEPARATION AND PURIFICATION TECHNOLOGY,  257  (117884).  [PMID:] [10.1016/j.seppur.2020.117884]
8. Lelin Zeng, Qian Liu, Bart Van der Bruggen, Kewen Tang, Xiang Yi, Guoxiang Wang.  (2020)  An integrated separation process for recovery and enantioseparation of amlodipine from wastewater: Supported liquid membrane-aqueous/organic phase crystallization.  SEPARATION AND PURIFICATION TECHNOLOGY,  248  (117121).  [PMID:] [10.1016/j.seppur.2020.117121]
9. Shuai Shao, Li Qian, Xin Zhan, Mengjie Wang, Kun Lu, Jianbiao Peng, Dong Miao, Shixiang Gao.  (2020)  Transformation and toxicity evolution of amlodipine mediated by cobalt ferrite activated peroxymonosulfate: Effect of oxidant concentration.  CHEMICAL ENGINEERING JOURNAL,  382  (123005).  [PMID:] [10.1016/j.cej.2019.123005]

Solution Calculators

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