Amonafide - ≥98%, high purity , CAS No.69408-81-7

Item Number

A126932

• Synonyms: 3-Amino-N-(2-(dimethylamino)ethyl)naphthalimide | AMONAFIDE [WHO-DD] | BCP9000321 | BDBM50033894 | NCGC00346513-01 | Quinamed | Benzisoquinolinedione | 5-Amino-2-(2-dimethylamino-ethyl)-benzo[de]isoquinoline-1,3-dione | 5-amino-2-(2-dimethylaminoethyl)ben
• Specifications & Purity: ≥98%
• Biochemical and Physiological Mechanisms: Amonafide is a DNA intercalator and Topo II (topoisomerase II) inhibitor for the treatment of neoplastic diseases. Antitumor agent.Selective topoisomerase II inhibitor. Induces DNA single-strand breaks, double-strand breaks, and DNA-protein cross-links. S
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
A DNA intercalator and topoisomerase II inhibitor