Ampicillin Na - USP grade, high purity , CAS No.69-52-3

Item Number
A105483
Grouped product items
SKUSizeAvailabilityPrice Qty
A105483-5g
5g
In stock
$17.90
A105483-25g
25g
In stock
$54.90
A105483-100g
100g
In stock
$180.90
A105483-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$653.90

β-lactam antibiotic agent

View related series
Anti-infection Antibiotic Bacterial

Basic Description

SynonymsAMPICILLIN SODIUM (USP MONOGRAPH) | sodium (2S,5R,6R)-6-{[(2R)-2-amino-2-phenylacetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate | A836527 | Ampicillin (as sodium) | AMPICILLIN SODIUM [GREEN BOOK] | D-(-)-alpha-Aminobenzylpe
Specifications & PurityPharmPure™, USP
Biochemical and Physiological MechanismsMode of Action: This is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with β-lactamase cleaves the β-lactam ring o
Storage TempStore at 2-8°C
Shipped InWet ice
GradePharmPure™, USP
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Ampicillin is reported as slightly soluble in water, practically insoluble in alcohol, chloroform, ether and fixed oils but soluble in dilute acids or bases. The solution should not be autoclaved; a stock solution should be sterilized through filtration and stored frozen, where it will be stable for months.
Used to select for ampicillin resistance in mutated and transformed cells.

Associated Targets(Human)

POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLA Tclin Alpha-galactosidase A (5444 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HSD17B10 Tchem Endoplasmic reticulum-associated amyloid beta-peptide-binding protein (20669 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLH Tchem DNA polymerase eta (21678 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4E Tchem Lysine-specific demethylase 4D-like (40243 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ftsZ Cell division protein ftsZ (97 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Streptococcus pneumoniae (31063 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ralstonia solanacearum (520 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus cereus (7522 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCT2 T-complex protein 1 subunit beta (5007 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488200395
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488200395
IUPAC Name sodium;(2S,5R,6R)-6-[[(2R)-2-amino-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
INCHI InChI=1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1
InChi Key KLOHDWPABZXLGI-YWUHCJSESA-M
Canonical SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=CC=C3)N)C(=O)[O-])C.[Na+]
Isomeric SMILES CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=CC=C3)N)C(=O)[O-])C.[Na+]
PubChem CID 23663979
Molecular Weight 371.39

Certificates

Certificate of Analysis(COA)

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32 results found

Lot NumberCertificate TypeDateItem
K2413165Certificate of AnalysisOct 21, 2024 A105483
K2413153Certificate of AnalysisOct 21, 2024 A105483
K2413155Certificate of AnalysisOct 21, 2024 A105483
K2413156Certificate of AnalysisOct 21, 2024 A105483
I2426160Certificate of AnalysisAug 21, 2024 A105483
I2426159Certificate of AnalysisAug 21, 2024 A105483
I2426157Certificate of AnalysisAug 21, 2024 A105483
I2426158Certificate of AnalysisAug 21, 2024 A105483
C2408167Certificate of AnalysisJul 27, 2023 A105483
J2318199Certificate of AnalysisJul 27, 2023 A105483
J2318198Certificate of AnalysisJul 27, 2023 A105483
J2318042Certificate of AnalysisJul 27, 2023 A105483
C2325045Certificate of AnalysisJan 12, 2023 A105483
C2325046Certificate of AnalysisJan 12, 2023 A105483
C2325047Certificate of AnalysisJan 12, 2023 A105483
C2325048Certificate of AnalysisJan 12, 2023 A105483
C2325049Certificate of AnalysisJan 12, 2023 A105483
C2325044Certificate of AnalysisJan 12, 2023 A105483
C2325043Certificate of AnalysisJan 12, 2023 A105483
K2209078Certificate of AnalysisSep 12, 2022 A105483
K2209082Certificate of AnalysisSep 12, 2022 A105483
K2209097Certificate of AnalysisSep 12, 2022 A105483
G2204052Certificate of AnalysisJul 07, 2022 A105483
G2204051Certificate of AnalysisJul 07, 2022 A105483
F2221227Certificate of AnalysisJul 01, 2022 A105483
H2212096Certificate of AnalysisJun 22, 2022 A105483
H2212404Certificate of AnalysisJun 22, 2022 A105483
H2212093Certificate of AnalysisJun 22, 2022 A105483
H2212067Certificate of AnalysisJun 22, 2022 A105483
E2205002Certificate of AnalysisMay 10, 2022 A105483
A2408071Certificate of AnalysisApr 02, 2022 A105483
C2223065Certificate of AnalysisMar 26, 2022 A105483

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Chemical and Physical Properties

SolubilityFreely soluble in water. Sparingly soluble in acetone
SensitivityMoisture sensitive.
Melt Point(°C)215°C

Safety and Hazards(GHS)

Pictogram(s) GHS08
Signal Danger
Hazard Statements

H317:May cause an allergic skin reaction

H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P284:[In case of inadequate ventilation] Wear respiratory protection.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P272:Contaminated work clothing should not be allowed out of the workplace.

P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention.

P362+P364:Take off contaminated clothing and wash it before reuse.

P342+P316:If experiencing respiratory symptoms: Get emergence medical help immediately.

Related Documents

Citations of This Product

1. Zhu Yongbo, Huang Lijun, Liang Meng, Zhang Zuokun, Xie Hao, Sheng Xingxin, Li Xinyi, Zhong Ming, Zhou Binbin.  (2023)  Green synthesis of plate-shaped CuONPs using Macleaya cordata (Wild.) R.BR extracts for photocatalytic degradation and antibacterial properties.  Biomass Conversion and Biorefinery,    (15): (1-13).  [PMID:14583450] [10.1007/s13399-023-04943-x]
2. Jiao Wei, Zongmei Zheng, Xinxin Hou, Fengjing Jia, Yuan Yuan, Fuwen Yuan, Feng He, Liang Hu, Ling Zhao.  (2024)  Echinacoside inhibits colorectal cancer metastasis via modulating the gut microbiota and suppressing the PI3K/AKT signaling pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  318  (116866).  [PMID:37429503] [10.1016/j.jep.2023.116866]
3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16).  [PMID:37147641] [10.1186/s12916-023-02880-0]
4. Fujian Qin, Jiankang Li, Tianxiao Mao, Shuo Feng, Jing Li, Maode Lai.  (2023)  2 Hydroxybutyric Acid-Producing Bacteria in Gut Microbiome and Fusobacterium nucleatum Regulates 2 Hydroxybutyric Acid Level In Vivo.  Metabolites,  13  (3): (451).  [PMID:36984891] [10.3390/metabo13030451]
5. Zhang Haotian, Wang Xiaohong, Xu Zuhui, Ma Jimei, Li Zi-Long, Cheng Wan-Min, Jiang Hong.  (2023)  A caprylate esterase–activated fluorescent probe for sensitive and selective detection of Salmonella enteritidis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (12): (2163-2172).  [PMID:36869898] [10.1007/s00216-023-04623-9]
6. Yajie Cai, Xiaojiaoyang Li, Qi Han, Jinzhao Bai, Qi Zheng, Rong Sun, Runping Liu.  (2023)  Si–Ni-San improves experimental colitis by favoring Akkermensia colonization.  JOURNAL OF ETHNOPHARMACOLOGY,  305  (116067).  [PMID:36586523] [10.1016/j.jep.2022.116067]
7. Zhen-Ping Zou, Yue Du, Ting-Ting Fang, Ying Zhou, Bang-Ce Ye.  (2023)  Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.  Cell Host & Microbe,  31  (199-212.e5).  [PMID:36758520] [10.1016/j.chom.2022.12.004]
8. Qianqian Yao, Linlin Fan, Nan Zheng, Christophe Blecker, Véronique Delcenserie, Huiying Li, Jiaqi Wang.  (2022)  2′-Fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression.  Frontiers in Nutrition,  (822020).  [PMID:35252301] [10.3389/fnut.2022.822020]
9. Xiuxiu Yang, Zhongqiang Yang.  (2022)  Simple and Rapid Detection of Ibuprofen─A Typical Pharmaceuticals and Personal Care Products─by a Liquid Crystal Aptasensor.  LANGMUIR,  38  (1): (282–288).  [PMID:34955019] [10.1021/acs.langmuir.1c02480]
10. Liu Yaqing, Lin Xiaodong, Ji Xiangyi, Hao Zhe, Tao Zhanhui.  (2020)  Smartphone-based enzyme-free fluorescence sensing of organophosphate DDVP.  MICROCHIMICA ACTA,  187  (7): (1-8).  [PMID:32613298] [10.1007/s00604-020-04384-7]
11. Xu Chen, Yanan Liu, Ange Lin, Na Huang, Liquan Long, Ye Gang, Jie Liu.  (2018)  Folic acid-modified mesoporous silica nanoparticles with pH-responsiveness loaded with Amp for an enhanced effect against anti-drug-resistant bacteria by overcoming efflux pump systems.  Biomaterials Science,  (7): (1923-1935).  [PMID:29850668] [10.1039/C8BM00262B]
12. Wang Jun, Ma Kui, Yin Huanshun, Zhou Yunlei, Ai Shiyun.  (2018)  Aptamer based voltammetric determination of ampicillin using a single-stranded DNA binding protein and DNA functionalized gold nanoparticles.  MICROCHIMICA ACTA,  185  (1): (1-7).  [PMID:29594557] [10.1007/s00604-017-2566-8]
13. Shi Hong, Liu Xueqing, Zhang Yuanfang.  (2014)  Fabrication of novel antimicrobial poly(vinyl chloride) plastic for automobile interior applications.  IRANIAN POLYMER JOURNAL,  23  (4): (297-305).  [PMID:] [10.1007/s13726-014-0226-y]
14. Zhiwei Qie,Jialei Bai,Bin Xie,Lin Yuan,Nan Song,Yuan Peng,Xianjun Fan,Huanying Zhou,Fengchun Chen,Shuang Li,Baoan Ning,Zhixian Gao.  (2015-06-11)  Sensitive detection of atrazine in tap water using TELISA..  The Analyst,  140  ((15)): (5220-5226).  [PMID:26061585]
15. Jingyi Hu,Hai Huang,Yuan Che,Chujie Ding,Lu Zhang,Yun Wang,Haiping Hao,Hong Shen,Lijuan Cao.  (2020-09-18)  Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function..  Journal of ethnopharmacology,  266  (113394-113394).  [PMID:32941971]

References

1. Zhu Yongbo, Huang Lijun, Liang Meng, Zhang Zuokun, Xie Hao, Sheng Xingxin, Li Xinyi, Zhong Ming, Zhou Binbin.  (2023)  Green synthesis of plate-shaped CuONPs using Macleaya cordata (Wild.) R.BR extracts for photocatalytic degradation and antibacterial properties.  Biomass Conversion and Biorefinery,    (15): (1-13).  [PMID:14583450] [10.1007/s13399-023-04943-x]
2. Jiao Wei, Zongmei Zheng, Xinxin Hou, Fengjing Jia, Yuan Yuan, Fuwen Yuan, Feng He, Liang Hu, Ling Zhao.  (2024)  Echinacoside inhibits colorectal cancer metastasis via modulating the gut microbiota and suppressing the PI3K/AKT signaling pathway.  JOURNAL OF ETHNOPHARMACOLOGY,  318  (116866).  [PMID:37429503] [10.1016/j.jep.2023.116866]
3. Zhang Yuntao, Liu Lin, Wei Chunbo, Wang Xuanyang, Li Ran, Xu Xiaoqing, Zhang Yingfeng, Geng Guannan, Dang Keke, Ming Zhu, Tao Xinmiao, Xu Huan, Yan Xuemin, Zhang Jia, Hu Jinxia, Li Ying.  (2023)  Vitamin K2 supplementation improves impaired glycemic homeostasis and insulin sensitivity for type 2 diabetes through gut microbiome and fecal metabolites.  BMC Medicine,  21  (1): (1-16).  [PMID:37147641] [10.1186/s12916-023-02880-0]
4. Fujian Qin, Jiankang Li, Tianxiao Mao, Shuo Feng, Jing Li, Maode Lai.  (2023)  2 Hydroxybutyric Acid-Producing Bacteria in Gut Microbiome and Fusobacterium nucleatum Regulates 2 Hydroxybutyric Acid Level In Vivo.  Metabolites,  13  (3): (451).  [PMID:36984891] [10.3390/metabo13030451]
5. Zhang Haotian, Wang Xiaohong, Xu Zuhui, Ma Jimei, Li Zi-Long, Cheng Wan-Min, Jiang Hong.  (2023)  A caprylate esterase–activated fluorescent probe for sensitive and selective detection of Salmonella enteritidis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (12): (2163-2172).  [PMID:36869898] [10.1007/s00216-023-04623-9]
6. Yajie Cai, Xiaojiaoyang Li, Qi Han, Jinzhao Bai, Qi Zheng, Rong Sun, Runping Liu.  (2023)  Si–Ni-San improves experimental colitis by favoring Akkermensia colonization.  JOURNAL OF ETHNOPHARMACOLOGY,  305  (116067).  [PMID:36586523] [10.1016/j.jep.2022.116067]
7. Zhen-Ping Zou, Yue Du, Ting-Ting Fang, Ying Zhou, Bang-Ce Ye.  (2023)  Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice.  Cell Host & Microbe,  31  (199-212.e5).  [PMID:36758520] [10.1016/j.chom.2022.12.004]
8. Qianqian Yao, Linlin Fan, Nan Zheng, Christophe Blecker, Véronique Delcenserie, Huiying Li, Jiaqi Wang.  (2022)  2′-Fucosyllactose Ameliorates Inflammatory Bowel Disease by Modulating Gut Microbiota and Promoting MUC2 Expression.  Frontiers in Nutrition,  (822020).  [PMID:35252301] [10.3389/fnut.2022.822020]
9. Xiuxiu Yang, Zhongqiang Yang.  (2022)  Simple and Rapid Detection of Ibuprofen─A Typical Pharmaceuticals and Personal Care Products─by a Liquid Crystal Aptasensor.  LANGMUIR,  38  (1): (282–288).  [PMID:34955019] [10.1021/acs.langmuir.1c02480]
10. Liu Yaqing, Lin Xiaodong, Ji Xiangyi, Hao Zhe, Tao Zhanhui.  (2020)  Smartphone-based enzyme-free fluorescence sensing of organophosphate DDVP.  MICROCHIMICA ACTA,  187  (7): (1-8).  [PMID:32613298] [10.1007/s00604-020-04384-7]
11. Xu Chen, Yanan Liu, Ange Lin, Na Huang, Liquan Long, Ye Gang, Jie Liu.  (2018)  Folic acid-modified mesoporous silica nanoparticles with pH-responsiveness loaded with Amp for an enhanced effect against anti-drug-resistant bacteria by overcoming efflux pump systems.  Biomaterials Science,  (7): (1923-1935).  [PMID:29850668] [10.1039/C8BM00262B]
12. Wang Jun, Ma Kui, Yin Huanshun, Zhou Yunlei, Ai Shiyun.  (2018)  Aptamer based voltammetric determination of ampicillin using a single-stranded DNA binding protein and DNA functionalized gold nanoparticles.  MICROCHIMICA ACTA,  185  (1): (1-7).  [PMID:29594557] [10.1007/s00604-017-2566-8]
13. Shi Hong, Liu Xueqing, Zhang Yuanfang.  (2014)  Fabrication of novel antimicrobial poly(vinyl chloride) plastic for automobile interior applications.  IRANIAN POLYMER JOURNAL,  23  (4): (297-305).  [PMID:] [10.1007/s13726-014-0226-y]
14. Zhiwei Qie,Jialei Bai,Bin Xie,Lin Yuan,Nan Song,Yuan Peng,Xianjun Fan,Huanying Zhou,Fengchun Chen,Shuang Li,Baoan Ning,Zhixian Gao.  (2015-06-11)  Sensitive detection of atrazine in tap water using TELISA..  The Analyst,  140  ((15)): (5220-5226).  [PMID:26061585]
15. Jingyi Hu,Hai Huang,Yuan Che,Chujie Ding,Lu Zhang,Yun Wang,Haiping Hao,Hong Shen,Lijuan Cao.  (2020-09-18)  Qingchang Huashi Formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function..  Journal of ethnopharmacology,  266  (113394-113394).  [PMID:32941971]

Solution Calculators