Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A115346-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $22.90 | |
A115346-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $49.90 | |
A115346-250mg | 250mg | In stock | $57.90 | |
A115346-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $199.90 |
Selective cAMP phosphodiesterase inhibitor. Positive inotropic agent.
Synonyms | AKOS005512516 | SPBio_002879 | AMRINONE [VANDF] | GTPL7202 | KBio1_000136 | inamrinone | Tox21_112110 | 3-Amino-5-(4-pyridinyl)-2(1H)-pyridinone | Amrinone [INN] | NINDS_000136 | Pharmakon1600-01503084 | Prestwick_44 | Spectrum_001350 | 3-amino-5-pyridin- |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Selective cAMP phosphodiesterase inhibitor (IC 50 values are 5 and 16 μM for 3A and 3B respectively). Positive inotropic agent. Shows anticonvulsive and vasodilatory effects in vivo. |
Storage Temp | Store at 2-8°C |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of phosphodiesterase 3A;Inhibitor of phosphodiesterase 3B |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-amino-5-pyridin-4-yl-1H-pyridin-2-one |
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INCHI | InChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14) |
InChi Key | RNLQIBCLLYYYFJ-UHFFFAOYSA-N |
Canonical SMILES | C1=CN=CC=C1C2=CNC(=O)C(=C2)N |
Isomeric SMILES | C1=CN=CC=C1C2=CNC(=O)C(=C2)N |
WGK Germany | 3 |
RTECS | DW2500000 |
PubChem CID | 3698 |
UN Number | 2811 |
Molecular Weight | 187.2 |
DrugBank Ligand | DB01427 |
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PubChem CID | 3698 |
CAS Registry No. | 60719-84-8 |
ChEMBL Ligand | CHEMBL12856 |
Wikipedia | Amrinone |
PEP | inamrinone |
DrugCentral Ligand | 201 |
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Solubility | Insoluble in water or chloroform. Slightly soluble in acetic acid or DMF. Soluble in DMSO |
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Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H301:Toxic if swallowed |
Precautionary Statements | P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P316:IF SWALLOWED: Get emergency medical help immediately. |
WGK Germany | 3 |
RTECS | DW2500000 |