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SKU | Size | Availability | Price | Qty |
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M127412-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $118.90 | |
M127412-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $535.90 | |
M127412-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,033.90 |
Synonyms | Amuvatinib | 850879-09-3 | MP-470 | MP470 | MP 470 | Amuvatinib (MP-470) | HPK56 | HPK 56 | HPK-56 | N-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide | N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperaz |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Amuvatinib is a potent and multi-targeted tyrosine kinase inhibitor that inhibits c-Kit and PDGFα and has been shown to induce apoptosis. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Platelet-derived growth factor receptor alpha inhibitor |
Note | 卖完停产,不再备货 |
Product Description | Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. |
ALogP | 3.5 |
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IUPAC Name | N-(1,3-benzodioxol-5-ylmethyl)-4-([1]benzofuro[3,2-d]pyrimidin-4-yl)piperazine-1-carbothioamide |
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INCHI | InChI=1S/C23H21N5O3S/c32-23(24-12-15-5-6-18-19(11-15)30-14-29-18)28-9-7-27(8-10-28)22-21-20(25-13-26-22)16-3-1-2-4-17(16)31-21/h1-6,11,13H,7-10,12,14H2,(H,24,32) |
InChi Key | FOFDIMHVKGYHRU-UHFFFAOYSA-N |
Canonical SMILES | C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6 |
Isomeric SMILES | C1CN(CCN1C2=NC=NC3=C2OC4=CC=CC=C43)C(=S)NCC5=CC6=C(C=C5)OCO6 |
PubChem CID | 11282283 |
Molecular Weight | 447.52 |
CAS Registry No. | 850879-09-3 |
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PubChem CID | 11282283 |
ChEMBL Ligand | CHEMBL2103851 |
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Solubility | DMSO 32 mg/mL Water <1 mg/mL Ethanol <1 mg/mL |
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1. Mahadevan D, Cooke L, Riley C, Swart R, Simons B, Della Croce K, Wisner L, Iorio M, Shakalya K, Garewal H et al.. (2007) A novel tyrosine kinase switch is a mechanism of imatinib resistance in gastrointestinal stromal tumors.. Oncogene, 26 (27): (3909-19). [PMID:17325667] |
2. Welsh JW, Mahadevan D, Ellsworth R, Cooke L, Bearss D, Stea B. (2009) The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells.. Radiat Oncol, 4 (3): (69). [PMID:20028557] |
3. Zhao H, Luoto KR, Meng AX, Bristow RG. (2011) The receptor tyrosine kinase inhibitor amuvatinib (MP470) sensitizes tumor cells to radio- and chemo-therapies in part by inhibiting homologous recombination.. Radiother Oncol, 101 (1): (59-65). [PMID:21903282] |