Amylin, amide, rat acetate, CAS No.124447-81-0(free), Agonist of AMY 1 receptor;Agonist of AMY 2 receptor;Agonist of AMY 3 receptor;Agonist of CT receptor

Features and benefits
    Item Number
    A288235
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    A288235-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $281.90
    A288235-5mg
    5mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $725.90

    Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors

    Basic Description

    Product NameAmylin, amide, rat acetate, CAS No.124447-81-0(free)
    GradeMoligand™
    Product Description

    Amylin, amide, rat is a potent and high affinity ligand of Amylin receptor AMY1 and AMY3 receptors and variably of AMY2 receptors; binding studies are generally used for the latter receptor.

    Specifications & PurityMoligand™, ≥95%
    Biochemical and Physiological MechanismsPotent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors (pEC50values are 7.06-9.50 at hCTa, 8.11 at rCTa, 7.73-10.1 at hAMY1a, 9.74 at rAMY1a, 7.92 at hAMY1b, 7.78-9.9 at hAMY2a, 7.94 at hAMY2b, 8.09-10.8 at hAMY3a, 9.9
    SequenceKCNTATCATQRLANFLVRSSNNLGPVLPPTNVGSNTY(Modifications: Tyr-37 = C-terminal amide, Disulfide bridge between 2 - 7)
    Action TypeAGONIST
    Mechanism of actionAgonist of AMY 1 receptor;Agonist of AMY 2 receptor;Agonist of AMY 3 receptor;Agonist of CT receptor

    Associated Targets(Human)

    RAMP2 Tclin Receptor activity-modifying protein 2 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    RAMP1 Tclin Receptor activity-modifying protein 1 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    RAMP3 Tclin Receptor activity-modifying protein 3 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    CALCR Tclin Calcitonin receptor (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    Storage TempProtected from light,Store at -20°C
    Shipped InIce chest + Ice pads
    CAS124447-81-0(free)

    Certificates

    Certificate of Analysis(COA)

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    4 results found

    Lot NumberCertificate TypeDateItem
    A2420011Certificate of AnalysisDec 23, 2023 A288235
    A2420012Certificate of AnalysisDec 23, 2023 A288235
    A2420013Certificate of AnalysisDec 23, 2023 A288235
    A2420014Certificate of AnalysisDec 23, 2023 A288235

    Genetic information

    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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