Grouped product items

SKU

Size

Availability

Price

Qty

A412314-5mg

5mg

Available within 8-12 weeks(?)

$66.90

A412314-10mg

10mg

Available within 8-12 weeks(?)

$287.90

A412314-25mg

25mg

Available within 8-12 weeks(?)

$174.90

A412314-50mg

50mg

Available within 8-12 weeks(?)

$448.90

A412314-100mg

100mg

Available within 8-12 weeks(?)

$574.90

Basic Description

Synonyms	ML136; CS-2122; (E)-2-(4-fluorophenyl)sulfonyl-3-[1-(3-nitrophenyl)sulfonylpyrrol-2-yl]prop-2-enenitrile
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	AMZ30 (ML136, CS-2122) is a selective and covalent inhibitor of protein phosphatase methylesterase-1(PME-1) with IC50 of 0.60 μM. AMZ30 reduces the demethylated form of PP2A in living cells.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	PME-1 (Cell-free assay) 0.60 μM

Associated Targets(Human)

PPME1 Tchem Protein phosphatase methylesterase 1 (2 Activities)

Discover Target: PPME1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTH1R Tclin Parathyroid hormone receptor (47172 Activities)

Discover Target: PTH1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PRCP Tchem Lysosomal Pro-X carboxypeptidase (567 Activities)

Discover Target: PRCP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLA2G4A Tchem Cytosolic phospholipase A2 (785 Activities)

Discover Target: PLA2G4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLA2G15 Tbio Lysosomal phospholipase A2 (3 Activities)

Discover Target: PLA2G15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)

Discover Target: PLK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FASN Tchem Fatty acid synthase (3390 Activities)

Discover Target: FASN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PAFAH1B2 Tchem Platelet-activating factor acetylhydrolase IB beta subunit (79 Activities)

Discover Target: PAFAH1B2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PAFAH1B3 Tbio Platelet-activating factor acetylhydrolase IB gamma subunit (3 Activities)

Discover Target: PAFAH1B3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DPP8 Tchem Dipeptidyl peptidase VIII (2139 Activities)

Discover Target: DPP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DPP9 Tchem Dipeptidyl peptidase IX (1624 Activities)

Discover Target: DPP9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NCEH1 Tchem Neutral cholesterol ester hydrolase 1 (158 Activities)

Discover Target: NCEH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DAGLB Tchem Sn1-specific diacylglycerol lipase beta (17 Activities)

Discover Target: DAGLB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CTSA Tchem Lysosomal protective protein (919 Activities)

Discover Target: CTSA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPME1 Tchem Protein phosphatase methylesterase 1 (52 Activities)

Discover Target: PPME1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LYPLA1 Tchem Acyl-protein thioesterase 1 (16 Activities)

Discover Target: LYPLA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEH Tchem Acylamino-acid-releasing enzyme (14 Activities)

Discover Target: APEH

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TEX30 Tdark Testis-expressed sequence 30 protein (1 Activities)

Discover Target: TEX30

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PNPLA8 Tbio Calcium-independent phospholipase A2-gamma (1 Activities)

Discover Target: PNPLA8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PREPL Tchem Prolyl endopeptidase-like (1 Activities)

Discover Target: PREPL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PNPLA6 Tbio Neuropathy target esterase (1 Activities)

Discover Target: PNPLA6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ESD Tchem S-formylglutathione hydrolase (14 Activities)

Discover Target: ESD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SCPEP1 Tbio Retinoid-inducible serine carboxypeptidase (1 Activities)

Discover Target: SCPEP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABHD17B Tbio Abhydrolase domain-containing protein FAM108B1 (3 Activities)

Discover Target: ABHD17B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LYPLAL1 Tbio Lysophospholipase-like protein 1 (1 Activities)

Discover Target: LYPLAL1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABHD11 Tbio Alpha/beta hydrolase domain-containing protein 11 (4 Activities)

Discover Target: ABHD11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACOT2 Tbio Acyl-coenzyme A thioesterase 2, mitochondrial (1 Activities)

Discover Target: ACOT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACOT1 Tbio Acyl-coenzyme A thioesterase 1 (1 Activities)

Discover Target: ACOT1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPT2 Tbio Lysosomal thioesterase PPT2 (1 Activities)

Discover Target: PPT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

PREP Prolyl endopeptidase (14 Activities)

Discover Target: PREP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Abhd16a Protein BAT5 (9 Activities)

Discover Target: Abhd16a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Abhd6 Monoacylglycerol lipase ABHD6 (221 Activities)

Discover Target: Abhd6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(E)-2-(4-fluorophenyl)sulfonyl-3-[1-(3-nitrophenyl)sulfonylpyrrol-2-yl]prop-2-enenitrile
INCHI	InChI=1S/C19H12FN3O6S2/c20-14-6-8-17(9-7-14)30(26,27)19(13-21)11-15-4-2-10-22(15)31(28,29)18-5-1-3-16(12-18)23(24)25/h1-12H/b19-11+
InChi Key	GUCUORSUHTZMBW-YBFXNURJSA-N
Canonical SMILES	C1=CC(=CC(=C1)S(=O)(=O)N2C=CC=C2C=C(C#N)S(=O)(=O)C3=CC=C(C=C3)F)[N+](=O)[O-]
Isomeric SMILES	C1=CC(=CC(=C1)S(=O)(=O)N2C=CC=C2/C=C(\C#N)/S(=O)(=O)C3=CC=C(C=C3)F)[N+](=O)[O-]
PubChem CID	44607965
Molecular Weight	461.44

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
B2418479	Certificate of Analysis	Jan 09, 2024	A412314
B2419662	Certificate of Analysis	Jan 09, 2024	A412314
B2419663	Certificate of Analysis	Jan 09, 2024	A412314
B2419664	Certificate of Analysis	Jan 09, 2024	A412314
B2419666	Certificate of Analysis	Jan 09, 2024	A412314
B2419760	Certificate of Analysis	Jan 09, 2024	A412314
B2419762	Certificate of Analysis	Jan 09, 2024	A412314
B2419763	Certificate of Analysis	Jan 09, 2024	A412314
B2419764	Certificate of Analysis	Jan 09, 2024	A412314
B2419765	Certificate of Analysis	Jan 09, 2024	A412314
B2419766	Certificate of Analysis	Jan 09, 2024	A412314

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Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 92 mg/mL (199.37 mM); Water: Insoluble; Ethanol: Insoluble;

Safety and Hazards(GHS)

Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

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AMZ30 - 98%, high purity , CAS No.1313613-09-0

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

SKU	Size	Availability	Price
A412314-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$66.90
A412314-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$287.90
A412314-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$174.90
A412314-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$448.90
A412314-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$574.90