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Andrographolide - 98%, high purity , CAS No.5508-58-7, Agonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8

2 Citations
Item Number
A101649
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
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25g
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100g
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$15,483.90
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500g
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Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69,677.90
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Inhibits NFκB; blocks androgen receptor (AR) expression

View related series
TAS2R46 Agonist TAS2R50 Agonist TAS2R8 Agonist

Basic Description

SynonymsANDROGRAPHOLIDE [MI] | DTXCID1025980 | Q-100624 | DTXSID3045980 | (S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2 | BRD-K89282837-001-01-0 | NSC-115849 | Q475
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsInhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγproduction in murine T cells (IC50= 1.7μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extrac
Shipped InNormal
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8
Note100mg卖完停产，不再备货
Product Description

Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus

Associated Targets(Human)

TAS2R8 Tchem Taste receptor type 2 member 8 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TAS2R46 Tchem Taste receptor type 2 member 46 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TAS2R50 Tchem Taste receptor type 2 member 50 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MGAM Tclin Maltase-glucoamylase (654 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR1H4 Tclin Bile acid receptor FXR (6228 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
STAT3 Tchem Signal transducer and activator of transcription 3 (3313 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit (1459 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NOS3 Tchem Nitric-oxide synthase, endothelial (1452 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GBA3 Tbio Beta-glucosidase cytosolic (63 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AKT1 Tchem Serine/threonine-protein kinase AKT (9192 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NFKBIA Tchem NF-kappaB inhibitor alpha (187 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
5637 (630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2058 (690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A498 (42825 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHN (49357 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Calu-3 (339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DU-145 (51482 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-8 (3484 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KM12 (47707 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
M14 (47487 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-361 (612 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-468 (9477 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SGC-7901 (2773 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-2 (46422 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-28 (48833 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-MEL-5 (47095 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SN12C (47755 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THP-1 (11052 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-251 (51189 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-937 (7138 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
786-0 (47912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI/ADR-RES (33767 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
T47D (39041 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Col2 (437 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EKVX (44102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H322M (45589 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NCI-H460 (60772 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hk2 Hexokinase type II (49 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rhizopus arrhizus (810 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas fluorescens (1630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Micrococcus luteus (7463 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Haemophilus influenzae (8812 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus niger (16508 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus fumigatus (16427 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis B virus (7925 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Influenza A virus (11224 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Dengue virus (413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus (3636 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
B16 (5829 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
J774.A1 (2436 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RAW264.7 (28094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RBL-2H3 (1162 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BV-2 (3710 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NIH3T3 (5395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-22 (3261 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Protease (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Akt1 RAC-alpha serine/threonine-protein kinase (147 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
[Candida] sake (415 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
dengue virus type 2 (2400 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
enterovirus D68 (324 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 Mitogen-activated protein kinase 1 and 3 (ERK2 and ERK1) (70 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Henosepilachna vigintioctopunctata (143 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mythimna separata (3306 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Influenza A virus H3N2 (588 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chikungunya virus (1339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero C1008 (1716 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488195335
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195335
IUPAC Name (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
INCHI InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1
InChi Key BOJKULTULYSRAS-OTESTREVSA-N
Canonical SMILES CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O
Isomeric SMILES C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\[C@@H](COC3=O)O)(C)CO)O
WGK Germany 3
RTECS LU3490750
Alternate CAS 5508-58-7
PubChem CID 5318517
MeSH Entry Terms 17-hydro-9-dehydro-andrographolide;andrographolide;isoandrographolide
Molecular Weight 350.45
Beilstein 42762

Certificates

Certificate of Analysis(COA)

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13 results found

Lot NumberCertificate TypeDateItem
D2303438Certificate of AnalysisFeb 13, 2023 A101649
D2303440Certificate of AnalysisFeb 13, 2023 A101649
D2303461Certificate of AnalysisFeb 13, 2023 A101649
D2303462Certificate of AnalysisFeb 13, 2023 A101649
D2303464Certificate of AnalysisFeb 13, 2023 A101649
D2303465Certificate of AnalysisFeb 13, 2023 A101649
D2303466Certificate of AnalysisFeb 13, 2023 A101649
D2303469Certificate of AnalysisFeb 13, 2023 A101649
B2321253Certificate of AnalysisMay 21, 2022 A101649
F2209068Certificate of AnalysisMay 21, 2022 A101649
F2209080Certificate of AnalysisMay 21, 2022 A101649
F2209088Certificate of AnalysisMay 21, 2022 A101649
G1813060Certificate of AnalysisMay 10, 2022 A101649

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 35.05, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.5, Max Conc. mM: 10
Specific Rotation[α]-126° (C=1.5,AcOH)
Melt Point(°C)229-232°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS LU3490750
Merck Index 633

Related Documents

 SDS

 Specification Sheet

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FAQs and Articles

FAQ
RNA Viruses Triggered Signal Pathway
Categories: Technical articles
Tags:
NF-kB signaling pathway Signaling pathway RNA virus NF-kB

Citations of This Product

1. Yonglei Yuan,Long Ji,Liping Luo,Juan Lu,Xiaoqiong Ma,Zhongjun Ma,Zhe Chen.  (2012-09-11)  Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide..  Fitoterapia,  83  ((8)): (1506-1513).  [PMID:22960348]
2. Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi Li.  (2023)  Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection.  FOOD AND CHEMICAL TOXICOLOGY,  172  (113584).  [PMID:36581090]

References

1. Nguyen VS, Loh XY, Wijaya H, Wang J, Lin Q, Lam Y, Wong WS, Mok YK.  (2015)  Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50..  J Nat Prod,  78  (2): (208-17).  [PMID:25615020]
2. Peng S, Gao J, Liu W, Jiang C, Yang X, Sun Y, Guo W, Xu Q.  (2016)  Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation..  Oncotarget,  7  (49): (80262-80274).  [PMID:27793052]
3. Tan WSD, Liao W, Zhou S, Wong WSF.  (2017)  Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action..  Biochem Pharmacol,  139  (3): (71-81).  [PMID:28377280]
4. Cui-Ling Qi,Li-Jing Wang,Xin-Lei Zhou.  (2008-03-01)  [Advances in study on anti-tumor mechanism of andrographolide]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  32  ((20)): (2095-2097).  [PMID:18306735]
5. Jonathan Chee Woei Lim,Tze Khee Chan,David S W Ng,Sreenivasa R Sagineedu,Johnson Stanslas,W S Fred Wong.  (2011-10-25)  Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer..  Clinical and experimental pharmacology & physiology,  39  ((3)): (300-310).  [PMID:22017767]
6. Chantana Aromdee.  (2012-02-15)  Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011)..  Expert opinion on therapeutic patents,  22  ((2)): (169-180).  [PMID:22329509]
7. Minghua Yang,Junsong Wang,Lingyi Kong.  (2012-06-29)  Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations..  Journal of pharmaceutical and biomedical analysis,  70  (87-93).  [PMID:22738787]
8. Wan J Lu,Kuan H Lin,Ming J Hsu,Duen S Chou,George Hsiao,Joen R Sheu.  (2012-07-10)  Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade..  Biochemical pharmacology,  84  ((7)): (914-924).  [PMID:22771630]
9. S Kumar,H S Patil,P Sharma,D Kumar,S Dasari,V G Puranik,H V Thulasiram,G C Kundu.  (2012-07-19)  Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway..  Current molecular medicine,  12  ((8)): (952-966).  [PMID:22804248]
10. Mayur M Uttekar,Tiyasa Das,Rohan S Pawar,Beena Bhandari,Vidya Menon,Nutan,Satish K Gupta,Sujata V Bhat.  (2012-08-04)  Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding..  European journal of medicinal chemistry,  56  (368-374).  [PMID:22858223]
11. Wei Chen,Lina Feng,Hao Nie,Xiaodong Zheng.  (2012-08-08)  Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore..  Carcinogenesis,  33  ((11)): (2190-2198).  [PMID:22869602]
12. Yonglei Yuan,Long Ji,Liping Luo,Juan Lu,Xiaoqiong Ma,Zhongjun Ma,Zhe Chen.  (2012-09-11)  Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide..  Fitoterapia,  83  ((8)): (1506-1513).  [PMID:22960348]
13. Qi Zhao,Jie Ding,Haiyan Jin,Lan Ding,Nanqi Ren.  (2012-09-15)  A green method using a micellar system for determination of andrographolide and dehydroandrographolide in human plasma..  Journal of chromatographic science,  51  ((4)): (341-348).  [PMID:22977119]
14. Sun-Wei Guo,Xiaoyan Mao,Qingliang Ma,Xishi Liu.  (2012-09-25)  Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis..  Fertility and sterility,  99  ((1)): (231-240).  [PMID:22999795]
15. Shuang-Qing Zhang,Yu-Ming Fan.  (2012-09-27)  Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  907  (173-177).  [PMID:23010480]
16. Wenjie Guo,Wen Liu,Gong Chen,Shaocheng Hong,Cheng Qian,Ning Xie,Xiaoling Yang,Yang Sun,Qiang Xu.  (2012-10-06)  Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways..  International immunopharmacology,  14  ((4)): (613-619).  [PMID:23036579]
17. Zhong Rong Zhang,Mazen Al Zaharna,Matthew Man-Kin Wong,Sung-Kay Chiu,Hon-Yeung Cheung.  (2013-02-06)  Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation..  PloS one,  8  ((1)): (e54577-e54577).  [PMID:23382917]
18. Tao Zhu,Dao-xin Wang,Wei Zhang,Xiu-qing Liao,Xian Guan,Hong Bo,Jia-yang Sun,Ni-wen Huang,Jing He,Yun-kun Zhang,Jing Tong,Chang-yi Li.  (2013-02-26)  Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB..  PloS one,  8  ((2)): (e56407-e56407).  [PMID:23437127]
19. Harrison J Hocker,Kwang-Jin Cho,Chung-Ying K Chen,Nandini Rambahal,Sreenivasa Rao Sagineedu,Khozirah Shaari,Johnson Stanslas,John F Hancock,Alemayehu A Gorfe.  (2013-06-06)  Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function..  Proceedings of the National Academy of Sciences of the United States of America,  110  ((25)): (10201-10206).  [PMID:23737504]
20. Guo-Qing Bao,Bai-Yong Shen,Chun-Peng Pan,Ya-Jing Zhang,Min-Min Shi,Cheng-Hong Peng.  (2013-07-13)  Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer..  Toxicology letters,  222  ((1)): (23-35).  [PMID:23845849]
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23. Chia-Yang Lu,Ya-Chen Yang,Chien-Chun Li,Kai-Li Liu,Chong-Kuei Lii,Haw-Wen Chen.  (2014-07-08)  Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells..  Biochemical pharmacology,  91  ((1)): (40-50).  [PMID:24998495]
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25. Xiang Li,Tianyi Wang,Dongping Zhang,Haiying Li,Haitao Shen,Xin Ding,Gang Chen.  (2018-09-16)  Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction..  Neuropharmacology,  141  (305-315).  [PMID:30218674]
26. Jian Gao,Shuang Peng,Xinni Shan,Guoliang Deng,Lihong Shen,Jian Sun,Chunhong Jiang,Xiaoling Yang,Zhigang Chang,Xinchen Sun,Fude Feng,Lingdong Kong,Yanhong Gu,Wenjie Guo,Qiang Xu,Yang Sun.  (2019-12-22)  Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis..  Cell death & disease,  10  ((12)): (957-957).  [PMID:31862870]
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28. Tao Yang,Hai-xia Shi,Zheng-tao Wang,Chang-hong Wang.  (2012-06-30)  Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats..  Phytotherapy research : PTR,  27  ((4)): (618-623).  [PMID:22744979]
29. Suryakala Gandi,Kiranmayee Rao,Bhuvaneswari Chodisetti,Archana Giri.  (2012-09-25)  Elicitation of andrographolide in the suspension cultures of Andrographis paniculata..  Applied biochemistry and biotechnology,  168  ((7)): (1729-1738).  [PMID:23001530]
30. R Krithika,R J Verma,P S Shrivastav.  (2012-10-02)  Antioxidative and cytoprotective effects of andrographolide against CCl4-induced hepatotoxicity in HepG2 cells..  Human & experimental toxicology,  32  ((5)): (530-543).  [PMID:23023025]
31. Myra T W Cheung,Rajkumar Ramalingam,Kenneth K K Lau,W L Chiang,S K Chiu.  (2012-10-11)  Cell type-dependent effects of andrographolide on human cancer cell lines..  Life sciences,  91  ((15-16)): (751-760).  [PMID:23047020]
32. Partha Roy,Suvadra Das,Anushree Mondal,Urmi Chatterji,Arup Mukherjee.  (2012-10-18)  Nanoparticle engineering enhances anticancer efficacy of andrographolide in MCF-7 cells and mice bearing EAC..  Current pharmaceutical biotechnology,  13  ((15)): (2669-2681).  [PMID:23072387]
33. Yan Guan,Jiuyun Zhang,Changzhong Wang,Ning Wang,Zhifang Liu,Jingjin Shi.  (2012-11-07)  [Preliminary study of effects of andrographolide on Staphylococcus epidermidis biofilms]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((14)): (2147-2150).  [PMID:23126203]
34. Yong-Yang Zhu,Guangchuang Yu,Ye Zhang,Zheng Xu,Yu-Qiang Wang,Guang-Rong Yan,Qing-Yu He.  (2012-11-20)  A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism..  Proteomics,  13  ((1)): (169-178).  [PMID:23161516]
35. S Manoharan,Arjun Kumar Singh,K Suresh,K Vasudevan,R Subhasini,N Baskaran.  (2013-01-16)  Anti-tumor initiating potential of andrographolide in 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis..  Asian Pacific journal of cancer prevention : APJCP,  13  ((11)): (5701-5708).  [PMID:23317242]
36. Bin Zhou,Dayong Zhang,Xiaoming Wu.  (2013-02-27)  Biological activities and corresponding SARs of andrographolide and its derivatives..  Mini reviews in medicinal chemistry,  13  ((2)): (298-309).  [PMID:23438057]
37. X P Li,C L Zhang,P Gao,J Gao,D Liu.  (2013-03-30)  Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats..  Drug research,  63  ((5)): (258-262).  [PMID:23539425]
38. Shao-Ying Hu,Zhen-Hai Zhang,Xiao-Bin Jia.  (2013-05-15)  [Study on andrographolide solid dispersion vectored by hydroxyapatite]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  38  ((3)): (341-345).  [PMID:23668005]
39. Ting-Lin Yen,Wen-Hsien Hsu,Steven Kuan-Hua Huang,Wan-Jung Lu,Chao-Chien Chang,Li-Ming Lien,George Hsiao,Joen-Rong Sheu,Kuan-Hung Lin.  (2013-08-13)  A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis..  Pharmaceutical biology,  51  ((9)): (1150-1157).  [PMID:23930775]
40. Nurhanan M Yunos,Siti S M Mutalip,Muhammad H Jauri,Jun Q Yu,Fazlul Huq.  (2013-10-15)  Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines..  Anticancer research,  33  ((10)): (4365-4371).  [PMID:24123004]
41. Hai-Ying Ma,Dong-Xue Sun,Yun-Feng Cao,Chun-Zhi Ai,Yan-Qing Qu,Cui-Min Hu,Changtao Jiang,Pei-Pei Dong,Xiao-Yu Sun,Mo Hong,Naoki Tanaka,Frank J Gonzalez,Xiao-Chi Ma,Zhong-Ze Fang.  (2014-03-19)  Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7..  Toxicology and applied pharmacology,  277  ((1)): (86-94).  [PMID:24631340]
42. Lili Ding,Jinmei Li,Baoliang Song,Xu Xiao,Wendong Huang,Binfeng Zhang,Xiaowen Tang,Meng Qi,Qiming Yang,Qiaoling Yang,Li Yang,Zhengtao Wang.  (2014-09-11)  Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway..  The Journal of pharmacology and experimental therapeutics,  351  ((2)): (474-483).  [PMID:25204338]
43. Rajesh Chandra Misra,Anchal Garg,Sudeep Roy,Chandan Singh Chanotiya,Prema G Vasudev,Sumit Ghosh.  (2015-10-18)  Involvement of an ent-copalyl diphosphate synthase in tissue-specific accumulation of specialized diterpenes in Andrographis paniculata..  Plant science : an international journal of experimental plant biology,  240  (50-64).  [PMID:26475187]
44. Eva Ramos-Fernández,Cheril Tapia-Rojas,Valerie T Ramírez,Nibaldo C Inestrosa.  (2018-07-04)  Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling..  Molecular neurobiology,  56  ((3)): (1870-1882).  [PMID:29967987]
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