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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A101649-100mg | 100mg | In stock | $58.90 | |
A101649-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $117.90 | |
A101649-1g | 1g | In stock | $212.90 | |
A101649-5g | 5g | In stock | $955.90 | |
A101649-25g | 25g | In stock | $4,301.90 | |
A101649-100g | 100g | In stock | $15,483.90 | |
A101649-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $69,677.90 |
Inhibits NFκB; blocks androgen receptor (AR) expression
Synonyms | ANDROGRAPHOLIDE [MI] | DTXCID1025980 | Q-100624 | DTXSID3045980 | (S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2 | BRD-K89282837-001-01-0 | NSC-115849 | Q475 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγproduction in murine T cells (IC50= 1.7μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extrac |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8 |
Note | 100mg卖完停产,不再备货 |
Product Description | Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488195335 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488195335 |
IUPAC Name | (3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one |
INCHI | InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1 |
InChi Key | BOJKULTULYSRAS-OTESTREVSA-N |
Canonical SMILES | CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O |
Isomeric SMILES | C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\[C@@H](COC3=O)O)(C)CO)O |
WGK Germany | 3 |
RTECS | LU3490750 |
Alternate CAS | 5508-58-7 |
PubChem CID | 5318517 |
MeSH Entry Terms | 17-hydro-9-dehydro-andrographolide;andrographolide;isoandrographolide |
Molecular Weight | 350.45 |
Beilstein | 42762 |
PubChem SID | 488195335 |
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Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D2303438 | Certificate of Analysis | Feb 13, 2023 | A101649 |
D2303440 | Certificate of Analysis | Feb 13, 2023 | A101649 |
D2303461 | Certificate of Analysis | Feb 13, 2023 | A101649 |
D2303462 | Certificate of Analysis | Feb 13, 2023 | A101649 |
D2303464 | Certificate of Analysis | Feb 13, 2023 | A101649 |
D2303465 | Certificate of Analysis | Feb 13, 2023 | A101649 |
D2303466 | Certificate of Analysis | Feb 13, 2023 | A101649 |
D2303469 | Certificate of Analysis | Feb 13, 2023 | A101649 |
B2321253 | Certificate of Analysis | May 21, 2022 | A101649 |
F2209068 | Certificate of Analysis | May 21, 2022 | A101649 |
F2209080 | Certificate of Analysis | May 21, 2022 | A101649 |
F2209088 | Certificate of Analysis | May 21, 2022 | A101649 |
G1813060 | Certificate of Analysis | May 10, 2022 | A101649 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 35.05, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.5, Max Conc. mM: 10 |
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Specific Rotation[α] | -126° (C=1.5,AcOH) |
Melt Point(°C) | 229-232°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | LU3490750 |
Merck Index | 633 |
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1. Yonglei Yuan,Long Ji,Liping Luo,Juan Lu,Xiaoqiong Ma,Zhongjun Ma,Zhe Chen. (2012-09-11) Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide.. Fitoterapia, 83 ((8)): (1506-1513). [PMID:22960348] |
2. Wenshu Zou, Kai Zhang, Zhengying Qiu, Ruihua Xin, Guibo Wang, Jingyan Zhang, Jianxi Li. (2023) Asiatic acid and andrographolide reduce hippocampal injury through suppressing neuroinflammation caused by Salmonella typhimurium infection. FOOD AND CHEMICAL TOXICOLOGY, 172 (113584). [PMID:36581090] [10.1016/j.fct.2022.113584] |
3. Zilong Chen, Hongdong Liu, Jie Chen, Weifeng Zhu, Yong Liu, Jianxin Min, Xiaotian Chen, Bin Li, Xin Yang. (2021) Separation and enrichment of sibiskoside from Sibiraea angustat with magnetic surface dummy template molecularly imprinted polymers. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1178 (122767). [PMID:34224966] [10.1016/j.jchromb.2021.122767] |
1. Nguyen VS, Loh XY, Wijaya H, Wang J, Lin Q, Lam Y, Wong WS, Mok YK. (2015) Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.. J Nat Prod, 78 (2): (208-17). [PMID:25615020] [10.1021/op500134e] |
2. Peng S, Gao J, Liu W, Jiang C, Yang X, Sun Y, Guo W, Xu Q. (2016) Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation.. Oncotarget, 7 (49): (80262-80274). [PMID:27793052] [10.1021/op500134e] |
3. Tan WSD, Liao W, Zhou S, Wong WSF. (2017) Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action.. Biochem Pharmacol, 139 (13): (71-81). [PMID:28377280] [10.1021/op500134e] |
4. Cui-Ling Qi,Li-Jing Wang,Xin-Lei Zhou. (2008-03-01) [Advances in study on anti-tumor mechanism of andrographolide].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32 ((20)): (2095-2097). [PMID:18306735] |
5. Jonathan Chee Woei Lim,Tze Khee Chan,David S W Ng,Sreenivasa R Sagineedu,Johnson Stanslas,W S Fred Wong. (2011-10-25) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.. Clinical and experimental pharmacology & physiology, 39 ((3)): (300-310). [PMID:22017767] |
6. Chantana Aromdee. (2012-02-15) Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011).. Expert opinion on therapeutic patents, 22 ((2)): (169-180). [PMID:22329509] |
7. Minghua Yang,Junsong Wang,Lingyi Kong. (2012-06-29) Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.. Journal of pharmaceutical and biomedical analysis, 70 (87-93). [PMID:22738787] |
8. Wan J Lu,Kuan H Lin,Ming J Hsu,Duen S Chou,George Hsiao,Joen R Sheu. (2012-07-10) Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade.. Biochemical pharmacology, 84 ((7)): (914-924). [PMID:22771630] |
9. S Kumar,H S Patil,P Sharma,D Kumar,S Dasari,V G Puranik,H V Thulasiram,G C Kundu. (2012-07-19) Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway.. Current molecular medicine, 12 ((8)): (952-966). [PMID:22804248] |
10. Mayur M Uttekar,Tiyasa Das,Rohan S Pawar,Beena Bhandari,Vidya Menon,Nutan,Satish K Gupta,Sujata V Bhat. (2012-08-04) Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding.. European journal of medicinal chemistry, 56 (368-374). [PMID:22858223] |
11. Wei Chen,Lina Feng,Hao Nie,Xiaodong Zheng. (2012-08-08) Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.. Carcinogenesis, 33 ((11)): (2190-2198). [PMID:22869602] |
12. Yonglei Yuan,Long Ji,Liping Luo,Juan Lu,Xiaoqiong Ma,Zhongjun Ma,Zhe Chen. (2012-09-11) Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide.. Fitoterapia, 83 ((8)): (1506-1513). [PMID:22960348] |
13. Qi Zhao,Jie Ding,Haiyan Jin,Lan Ding,Nanqi Ren. (2012-09-15) A green method using a micellar system for determination of andrographolide and dehydroandrographolide in human plasma.. Journal of chromatographic science, 51 ((4)): (341-348). [PMID:22977119] |
14. Sun-Wei Guo,Xiaoyan Mao,Qingliang Ma,Xishi Liu. (2012-09-25) Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis.. Fertility and sterility, 99 ((1)): (231-240). [PMID:22999795] |
15. Shuang-Qing Zhang,Yu-Ming Fan. (2012-09-27) Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907 (173-177). [PMID:23010480] |
16. Wenjie Guo,Wen Liu,Gong Chen,Shaocheng Hong,Cheng Qian,Ning Xie,Xiaoling Yang,Yang Sun,Qiang Xu. (2012-10-06) Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways.. International immunopharmacology, 14 ((4)): (613-619). [PMID:23036579] |
17. Zhong Rong Zhang,Mazen Al Zaharna,Matthew Man-Kin Wong,Sung-Kay Chiu,Hon-Yeung Cheung. (2013-02-06) Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation.. PloS one, 8 ((1)): (e54577-e54577). [PMID:23382917] |
18. Tao Zhu,Dao-xin Wang,Wei Zhang,Xiu-qing Liao,Xian Guan,Hong Bo,Jia-yang Sun,Ni-wen Huang,Jing He,Yun-kun Zhang,Jing Tong,Chang-yi Li. (2013-02-26) Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB.. PloS one, 8 ((2)): (e56407-e56407). [PMID:23437127] |
19. Harrison J Hocker,Kwang-Jin Cho,Chung-Ying K Chen,Nandini Rambahal,Sreenivasa Rao Sagineedu,Khozirah Shaari,Johnson Stanslas,John F Hancock,Alemayehu A Gorfe. (2013-06-06) Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.. Proceedings of the National Academy of Sciences of the United States of America, 110 ((25)): (10201-10206). [PMID:23737504] |
20. Guo-Qing Bao,Bai-Yong Shen,Chun-Peng Pan,Ya-Jing Zhang,Min-Min Shi,Cheng-Hong Peng. (2013-07-13) Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer.. Toxicology letters, 222 ((1)): (23-35). [PMID:23845849] |
21. Yuan-Yuan Yan,Gao-Xiang Shi,Jing Shao,Tian-Ming Wang,Chang-Zhong Wang. (2014-02-25) [Advance in studies on anti-infection of andrographolide and its derivatives in past 10 years].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38 ((22)): (3819-3824). [PMID:24558857] |
22. Emil Salim,Endang Kumolosasi,Ibrahim Jantan. (2014-05-07) Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells.. Journal of natural medicines, 68 ((3)): (647-653). [PMID:24799081] |
23. Chia-Yang Lu,Ya-Chen Yang,Chien-Chun Li,Kai-Li Liu,Chong-Kuei Lii,Haw-Wen Chen. (2014-07-08) Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells.. Biochemical pharmacology, 91 ((1)): (40-50). [PMID:24998495] |
24. Haw-Wen Chen,Chin-Shiu Huang,Chien-Chun Li,Ai-Hsuan Lin,Yu-Ju Huang,Tsu-Shing Wang,Hsien-Tsung Yao,Chong-Kuei Lii. (2014-08-12) Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats.. Toxicology and applied pharmacology, 280 ((1)): (1-9). [PMID:25110055] |
25. Xiang Li,Tianyi Wang,Dongping Zhang,Haiying Li,Haitao Shen,Xin Ding,Gang Chen. (2018-09-16) Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction.. Neuropharmacology, 141 (305-315). [PMID:30218674] |
26. Jian Gao,Shuang Peng,Xinni Shan,Guoliang Deng,Lihong Shen,Jian Sun,Chunhong Jiang,Xiaoling Yang,Zhigang Chang,Xinchen Sun,Fude Feng,Lingdong Kong,Yanhong Gu,Wenjie Guo,Qiang Xu,Yang Sun. (2019-12-22) Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis.. Cell death & disease, 10 ((12)): (957-957). [PMID:31862870] |
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