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Andrographolide - 98%, high purity , CAS No.5508-58-7, Agonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8

Moligand™
≥98%

CAS#: 5508-58-7
Formula: C₂₀H₃₀O₅
Molecular Weight: 350.45
Beilstein Registry Number: 42762
EC Number: 226-852-5
MDL number: MFCD07778082
PubChem CID: 5318517
PubChem SID: 488195335

Item Number

A101649

Grouped product items
SKU	Size	Availability	Price
A101649-100mg	100mg	In stock	$58.90
A101649-500mg	500mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$117.90
A101649-1g	1g	In stock	$212.90
A101649-5g	5g	In stock	$955.90
A101649-25g	25g	In stock	$4,301.90
A101649-100g	100g	In stock	$15,483.90
A101649-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$69,677.90

Inhibits NFκB; blocks androgen receptor (AR) expression

View related series

TAS2R46 Agonist TAS2R50 Agonist TAS2R8 Agonist

Basic Description

Synonyms	Andrographolide\|5508-58-7\|CHEBI:65408\|HMPL004\|UNII-410105JHGR\|DTXSID3045980\|410105JHGR\|EINECS 226-852-5\|(S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-on
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Inhibitor of NF-κB signaling; also attenuates concanavaline-induced IFNγproduction in murine T cells (IC50= 1.7μM). Blocks androgen receptor (AR) expression in AR-expressing C4-2 cells. Activates Nrf2 in BEAS-2B cells in response to cigarette smoke extrac
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of TAS2R46;Agonist of TAS2R50;Agonist of TAS2R8
Note	100mg卖完停产，不再备货
Product Description	Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological activities such as anti-inflammatory, anti-malarial, anti-cancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus

Associated Targets

GBA3 Tbio Cytosolic beta-glucosidase 0 Activities

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STAT3 Tchem Signal transducer and activator of transcription 3 0 Activities

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HK2 Tchem Hexokinase-2 0 Activities

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NFKBIA Tchem NF-kappa-B inhibitor alpha 0 Activities

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SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 0 Activities

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SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 0 Activities

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TAS2R8 Tchem Taste receptor type 2 member 8 0 Activities

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TAS2R46 Tchem Taste receptor type 2 member 46 0 Activities

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TAS2R50 Tchem Taste receptor type 2 member 50 0 Activities

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RELA Tchem Transcription factor p65 0 Activities

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MGAM Tclin Maltase-glucoamylase, intestinal 0 Activities

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NR1H4 Tclin Bile acid receptor 0 Activities

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

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ACHE Tclin Acetylcholinesterase 0 Activities

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AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

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BCHE Tclin Cholinesterase 0 Activities

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IDO1 Tchem Indoleamine 2,3-dioxygenase 1 0 Activities

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MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

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MAPK14 Tchem Mitogen-activated protein kinase 14 0 Activities

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NFKB1 Tclin Nuclear factor NF-kappa-B p105 subunit 0 Activities

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NOS3 Tchem Nitric oxide synthase, endothelial 0 Activities

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Names and Identifiers

Pubchem Sid	488195335
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488195335
IUPAC Name	(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one
INCHI	InChI=1S/C20H30O5/c1-12-4-7-16-19(2,9-8-17(23)20(16,3)11-21)14(12)6-5-13-15(22)10-25-18(13)24/h5,14-17,21-23H,1,4,6-11H2,2-3H3/b13-5+/t14-,15-,16+,17-,19+,20+/m1/s1
InChi Key	BOJKULTULYSRAS-OTESTREVSA-N
Canonical SMILES	CC12CCC(C(C1CCC(=C)C2CC=C3C(COC3=O)O)(C)CO)O
Isomeric SMILES	C[C@@]12CC[C@H]([C@@]([C@H]1CCC(=C)[C@H]2C/C=C/3\[C@@H](COC3=O)O)(C)CO)O
WGK Germany	3
RTECS	LU3490750
Alternate CAS	5508-58-7
PubChem CID	5318517
MeSH Entry Terms	17-hydro-9-dehydro-andrographolide;andrographolide;isoandrographolide
Molecular Weight	350.45
Beilstein	42762

Database links

PubChem SID	488195335

Certificates

Certificate of Analysis(COA)

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13 results found

Lot Number	Certificate Type	Date	Item
D2303438	Certificate of Analysis	Feb 13, 2023	A101649
D2303440	Certificate of Analysis	Feb 13, 2023	A101649
D2303461	Certificate of Analysis	Feb 13, 2023	A101649
D2303462	Certificate of Analysis	Feb 13, 2023	A101649
D2303464	Certificate of Analysis	Feb 13, 2023	A101649
D2303465	Certificate of Analysis	Feb 13, 2023	A101649
D2303466	Certificate of Analysis	Feb 13, 2023	A101649
D2303469	Certificate of Analysis	Feb 13, 2023	A101649
B2321253	Certificate of Analysis	May 21, 2022	A101649
F2209068	Certificate of Analysis	May 21, 2022	A101649
F2209080	Certificate of Analysis	May 21, 2022	A101649
F2209088	Certificate of Analysis	May 21, 2022	A101649
G1813060	Certificate of Analysis	May 10, 2022	A101649

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 35.05, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 3.5, Max Conc. mM: 10
Specific Rotation[α]	-126° (C=1.5,AcOH)
Melt Point(°C)	229-232°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	LU3490750
Merck Index	633

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FAQs and Articles

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RNA Viruses Triggered Signal Pathway

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NF-kB signaling pathway Signaling pathway RNA virus NF-kB

References

1. Nguyen VS, Loh XY, Wijaya H, Wang J, Lin Q, Lam Y, Wong WS, Mok YK. (2015) Specificity and inhibitory mechanism of andrographolide and its analogues as antiasthma agents on NF-κB p50.. J Nat Prod, 78 (2): (208-17). [PMID:25615020]
2. Peng S, Gao J, Liu W, Jiang C, Yang X, Sun Y, Guo W, Xu Q. (2016) Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation.. Oncotarget, 7 (49): (80262-80274). [PMID:27793052]
3. Tan WSD, Liao W, Zhou S, Wong WSF. (2017) Is there a future for andrographolide to be an anti-inflammatory drug? Deciphering its major mechanisms of action.. Biochem Pharmacol, 139 (3): (71-81). [PMID:28377280]
4. Cui-Ling Qi,Li-Jing Wang,Xin-Lei Zhou. (2008-03-01) [Advances in study on anti-tumor mechanism of andrographolide].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 32 ((20)): (2095-2097). [PMID:18306735]
5. Jonathan Chee Woei Lim,Tze Khee Chan,David S W Ng,Sreenivasa R Sagineedu,Johnson Stanslas,W S Fred Wong. (2011-10-25) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer.. Clinical and experimental pharmacology & physiology, 39 ((3)): (300-310). [PMID:22017767]
6. Chantana Aromdee. (2012-02-15) Modifications of andrographolide to increase some biological activities: a patent review (2006 - 2011).. Expert opinion on therapeutic patents, 22 ((2)): (169-180). [PMID:22329509]
7. Minghua Yang,Junsong Wang,Lingyi Kong. (2012-06-29) Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.. Journal of pharmaceutical and biomedical analysis, 70 (87-93). [PMID:22738787]
8. Wan J Lu,Kuan H Lin,Ming J Hsu,Duen S Chou,George Hsiao,Joen R Sheu. (2012-07-10) Suppression of NF-κB signaling by andrographolide with a novel mechanism in human platelets: regulatory roles of the p38 MAPK-hydroxyl radical-ERK2 cascade.. Biochemical pharmacology, 84 ((7)): (914-924). [PMID:22771630]
9. S Kumar,H S Patil,P Sharma,D Kumar,S Dasari,V G Puranik,H V Thulasiram,G C Kundu. (2012-07-19) Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 kinase/Akt signaling pathway.. Current molecular medicine, 12 ((8)): (952-966). [PMID:22804248]
10. Mayur M Uttekar,Tiyasa Das,Rohan S Pawar,Beena Bhandari,Vidya Menon,Nutan,Satish K Gupta,Sujata V Bhat. (2012-08-04) Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding.. European journal of medicinal chemistry, 56 (368-374). [PMID:22858223]
11. Wei Chen,Lina Feng,Hao Nie,Xiaodong Zheng. (2012-08-08) Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore.. Carcinogenesis, 33 ((11)): (2190-2198). [PMID:22869602]
12. Yonglei Yuan,Long Ji,Liping Luo,Juan Lu,Xiaoqiong Ma,Zhongjun Ma,Zhe Chen. (2012-09-11) Quinone reductase (QR) inducers from Andrographis paniculata and identification of molecular target of andrographolide.. Fitoterapia, 83 ((8)): (1506-1513). [PMID:22960348]
13. Qi Zhao,Jie Ding,Haiyan Jin,Lan Ding,Nanqi Ren. (2012-09-15) A green method using a micellar system for determination of andrographolide and dehydroandrographolide in human plasma.. Journal of chromatographic science, 51 ((4)): (341-348). [PMID:22977119]
14. Sun-Wei Guo,Xiaoyan Mao,Qingliang Ma,Xishi Liu. (2012-09-25) Dysmenorrhea and its severity are associated with increased uterine contractility and overexpression of oxytocin receptor (OTR) in women with symptomatic adenomyosis.. Fertility and sterility, 99 ((1)): (231-240). [PMID:22999795]
15. Shuang-Qing Zhang,Yu-Ming Fan. (2012-09-27) Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907 (173-177). [PMID:23010480]
16. Wenjie Guo,Wen Liu,Gong Chen,Shaocheng Hong,Cheng Qian,Ning Xie,Xiaoling Yang,Yang Sun,Qiang Xu. (2012-10-06) Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways.. International immunopharmacology, 14 ((4)): (613-619). [PMID:23036579]
17. Zhong Rong Zhang,Mazen Al Zaharna,Matthew Man-Kin Wong,Sung-Kay Chiu,Hon-Yeung Cheung. (2013-02-06) Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation.. PloS one, 8 ((1)): (e54577-e54577). [PMID:23382917]
18. Tao Zhu,Dao-xin Wang,Wei Zhang,Xiu-qing Liao,Xian Guan,Hong Bo,Jia-yang Sun,Ni-wen Huang,Jing He,Yun-kun Zhang,Jing Tong,Chang-yi Li. (2013-02-26) Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB.. PloS one, 8 ((2)): (e56407-e56407). [PMID:23437127]
19. Harrison J Hocker,Kwang-Jin Cho,Chung-Ying K Chen,Nandini Rambahal,Sreenivasa Rao Sagineedu,Khozirah Shaari,Johnson Stanslas,John F Hancock,Alemayehu A Gorfe. (2013-06-06) Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function.. Proceedings of the National Academy of Sciences of the United States of America, 110 ((25)): (10201-10206). [PMID:23737504]
20. Guo-Qing Bao,Bai-Yong Shen,Chun-Peng Pan,Ya-Jing Zhang,Min-Min Shi,Cheng-Hong Peng. (2013-07-13) Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer.. Toxicology letters, 222 ((1)): (23-35). [PMID:23845849]
21. Yuan-Yuan Yan,Gao-Xiang Shi,Jing Shao,Tian-Ming Wang,Chang-Zhong Wang. (2014-02-25) [Advance in studies on anti-infection of andrographolide and its derivatives in past 10 years].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38 ((22)): (3819-3824). [PMID:24558857]
22. Emil Salim,Endang Kumolosasi,Ibrahim Jantan. (2014-05-07) Inhibitory effect of selected medicinal plants on the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated human peripheral blood mononuclear cells.. Journal of natural medicines, 68 ((3)): (647-653). [PMID:24799081]
23. Chia-Yang Lu,Ya-Chen Yang,Chien-Chun Li,Kai-Li Liu,Chong-Kuei Lii,Haw-Wen Chen. (2014-07-08) Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells.. Biochemical pharmacology, 91 ((1)): (40-50). [PMID:24998495]
24. Haw-Wen Chen,Chin-Shiu Huang,Chien-Chun Li,Ai-Hsuan Lin,Yu-Ju Huang,Tsu-Shing Wang,Hsien-Tsung Yao,Chong-Kuei Lii. (2014-08-12) Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats.. Toxicology and applied pharmacology, 280 ((1)): (1-9). [PMID:25110055]
25. Xiang Li,Tianyi Wang,Dongping Zhang,Haiying Li,Haitao Shen,Xin Ding,Gang Chen. (2018-09-16) Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction.. Neuropharmacology, 141 (305-315). [PMID:30218674]
26. Jian Gao,Shuang Peng,Xinni Shan,Guoliang Deng,Lihong Shen,Jian Sun,Chunhong Jiang,Xiaoling Yang,Zhigang Chang,Xinchen Sun,Fude Feng,Lingdong Kong,Yanhong Gu,Wenjie Guo,Qiang Xu,Yang Sun. (2019-12-22) Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis.. Cell death & disease, 10 ((12)): (957-957). [PMID:31862870]
27. Xinjian Liu,Yifei Wang,Guisheng Li. (2003-09-16) [Advances in pharmacological study of andrographolide and its derivatives].. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 26 ((2)): (135-138). [PMID:12971398]
28. Tao Yang,Hai-xia Shi,Zheng-tao Wang,Chang-hong Wang. (2012-06-30) Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats.. Phytotherapy research : PTR, 27 ((4)): (618-623). [PMID:22744979]
29. Suryakala Gandi,Kiranmayee Rao,Bhuvaneswari Chodisetti,Archana Giri. (2012-09-25) Elicitation of andrographolide in the suspension cultures of Andrographis paniculata.. Applied biochemistry and biotechnology, 168 ((7)): (1729-1738). [PMID:23001530]
30. R Krithika,R J Verma,P S Shrivastav. (2012-10-02) Antioxidative and cytoprotective effects of andrographolide against CCl4-induced hepatotoxicity in HepG2 cells.. Human & experimental toxicology, 32 ((5)): (530-543). [PMID:23023025]
31. Myra T W Cheung,Rajkumar Ramalingam,Kenneth K K Lau,W L Chiang,S K Chiu. (2012-10-11) Cell type-dependent effects of andrographolide on human cancer cell lines.. Life sciences, 91 ((15-16)): (751-760). [PMID:23047020]
32. Partha Roy,Suvadra Das,Anushree Mondal,Urmi Chatterji,Arup Mukherjee. (2012-10-18) Nanoparticle engineering enhances anticancer efficacy of andrographolide in MCF-7 cells and mice bearing EAC.. Current pharmaceutical biotechnology, 13 ((15)): (2669-2681). [PMID:23072387]
33. Yan Guan,Jiuyun Zhang,Changzhong Wang,Ning Wang,Zhifang Liu,Jingjin Shi. (2012-11-07) [Preliminary study of effects of andrographolide on Staphylococcus epidermidis biofilms].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37 ((14)): (2147-2150). [PMID:23126203]
34. Yong-Yang Zhu,Guangchuang Yu,Ye Zhang,Zheng Xu,Yu-Qiang Wang,Guang-Rong Yan,Qing-Yu He. (2012-11-20) A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.. Proteomics, 13 ((1)): (169-178). [PMID:23161516]
35. S Manoharan,Arjun Kumar Singh,K Suresh,K Vasudevan,R Subhasini,N Baskaran. (2013-01-16) Anti-tumor initiating potential of andrographolide in 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis.. Asian Pacific journal of cancer prevention : APJCP, 13 ((11)): (5701-5708). [PMID:23317242]
36. Bin Zhou,Dayong Zhang,Xiaoming Wu. (2013-02-27) Biological activities and corresponding SARs of andrographolide and its derivatives.. Mini reviews in medicinal chemistry, 13 ((2)): (298-309). [PMID:23438057]
37. X P Li,C L Zhang,P Gao,J Gao,D Liu. (2013-03-30) Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats.. Drug research, 63 ((5)): (258-262). [PMID:23539425]
38. Shao-Ying Hu,Zhen-Hai Zhang,Xiao-Bin Jia. (2013-05-15) [Study on andrographolide solid dispersion vectored by hydroxyapatite].. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38 ((3)): (341-345). [PMID:23668005]
39. Ting-Lin Yen,Wen-Hsien Hsu,Steven Kuan-Hua Huang,Wan-Jung Lu,Chao-Chien Chang,Li-Ming Lien,George Hsiao,Joen-Rong Sheu,Kuan-Hung Lin. (2013-08-13) A novel bioactivity of andrographolide from Andrographis paniculata on cerebral ischemia/reperfusion-induced brain injury through induction of cerebral endothelial cell apoptosis.. Pharmaceutical biology, 51 ((9)): (1150-1157). [PMID:23930775]
40. Nurhanan M Yunos,Siti S M Mutalip,Muhammad H Jauri,Jun Q Yu,Fazlul Huq. (2013-10-15) Anti-proliferative and pro-apoptotic effects from sequenced combinations of andrographolide and cisplatin on ovarian cancer cell lines.. Anticancer research, 33 ((10)): (4365-4371). [PMID:24123004]
41. Hai-Ying Ma,Dong-Xue Sun,Yun-Feng Cao,Chun-Zhi Ai,Yan-Qing Qu,Cui-Min Hu,Changtao Jiang,Pei-Pei Dong,Xiao-Yu Sun,Mo Hong,Naoki Tanaka,Frank J Gonzalez,Xiao-Chi Ma,Zhong-Ze Fang. (2014-03-19) Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7.. Toxicology and applied pharmacology, 277 ((1)): (86-94). [PMID:24631340]
42. Lili Ding,Jinmei Li,Baoliang Song,Xu Xiao,Wendong Huang,Binfeng Zhang,Xiaowen Tang,Meng Qi,Qiming Yang,Qiaoling Yang,Li Yang,Zhengtao Wang. (2014-09-11) Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway.. The Journal of pharmacology and experimental therapeutics, 351 ((2)): (474-483). [PMID:25204338]
43. Rajesh Chandra Misra,Anchal Garg,Sudeep Roy,Chandan Singh Chanotiya,Prema G Vasudev,Sumit Ghosh. (2015-10-18) Involvement of an ent-copalyl diphosphate synthase in tissue-specific accumulation of specialized diterpenes in Andrographis paniculata.. Plant science : an international journal of experimental plant biology, 240 (50-64). [PMID:26475187]
44. Eva Ramos-Fernández,Cheril Tapia-Rojas,Valerie T Ramírez,Nibaldo C Inestrosa. (2018-07-04) Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling.. Molecular neurobiology, 56 ((3)): (1870-1882). [PMID:29967987]
45. Minyi Zhang,Meng Yang,Na Wang,Qingli Liu,Binxu Wang,Tongling Huang,Yan Tong,Yanlin Ming,Chi-Wai Wong,Jinsong Liu,Dongsheng Yao,Min Guan. (2020-05-19) Andrographolide modulates HNF4α activity imparting on hepatic metabolism.. Molecular and cellular endocrinology, 513 (110867-110867). [PMID:32422400]

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