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Angiotensin Ⅱ, human - 90%, high purity , CAS No.4474-91-3

Specifications & Purity:  90%
Item Number
A107852
Grouped product items
SKUSizeAvailabilityPrice Qty
A107852-5mg
5mg
In stock
$77.90
A107852-10mg
10mg
In stock
$140.90
A107852-25mg
25mg
In stock
$290.90
A107852-100mg
100mg
In stock
$1,046.90
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Discover Angiotensin Ⅱ, human by Aladdin Scientific in 90% for only $77.90. Available - in Ligands at Aladdin Scientific. Vasoconstrictor peptide Tags: .

Basic Description

SynonymsANGIOTENSIN II|4474-91-3|Angiotensin II human|Human angiotensin II|Hypertensin|Ang II|Angiotensin II (human)|Angiotensin II (mouse)|Giapreza|5-L-Isoleucineangiotensin II|5-Isoleucine-angiotensin II|Asp-Arg-Val-Tyr-Ile-His-Pro-Phe|1-8-Angiotensin I|Angiote
Specifications & Purity90%
Storage TempStore at -20°C
Shipped InDry ice

Names and Identifiers

IUPAC Name (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
INCHI InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
InChi Key CZGUSIXMZVURDU-JZXHSEFVSA-N
Canonical SMILES CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
Isomeric SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
WGK Germany 3
RTECS BW2165000
PubChem CID 172198
Molecular Weight 1046.18

Certificates

Certificate of Analysis(COA)

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15 results found

Lot NumberCertificate TypeDateItem
H2318187Certificate of AnalysisJul 15, 2023 A107852
H2318188Certificate of AnalysisJul 15, 2023 A107852
H2318189Certificate of AnalysisJul 15, 2023 A107852
H2318190Certificate of AnalysisJul 15, 2023 A107852
A2310302Certificate of AnalysisDec 01, 2022 A107852
A2310303Certificate of AnalysisDec 01, 2022 A107852
A2310312Certificate of AnalysisDec 01, 2022 A107852
A2310316Certificate of AnalysisDec 01, 2022 A107852
A2310321Certificate of AnalysisDec 01, 2022 A107852
A2310322Certificate of AnalysisDec 01, 2022 A107852
A2310330Certificate of AnalysisDec 01, 2022 A107852
A2310332Certificate of AnalysisDec 01, 2022 A107852
G2226045Certificate of AnalysisJun 05, 2022 A107852
G2226046Certificate of AnalysisJun 05, 2022 A107852
I2129182Certificate of AnalysisSep 18, 2021 A107852

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Chemical and Physical Properties

Solubilityinsoluble in DMSO; insoluble in EtOH
SensitivityHeat Sensitive

Safety and Hazards(GHS)

WGK Germany 3
RTECS BW2165000

Related Documents

 SDS

 Specification Sheet

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References

1. Wang L et al..  (2021)  Adropin inhibits the phenotypic modulation and proliferation of vascular smooth muscle cells during neointimal hyperplasia by activating the AMPK/ACC signaling pathway..  Exp Ther Med,  21  (6): (560).  [PMID:33850532]
2. Ageeva LV et al..  (2018)  Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro..  Data Brief,  16  (327-333).  [PMID:29234689]
3. Yang L et al..  (2017)  Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms..  Oncotarget,  8  (54): (92827-92840).  [PMID:29190959]
4. Liu J et al..  (2022)  Effects of angiotensin II combined with asparaginase and dexamethasone on the femoral head in mice: A model of steroid-induced femoral head osteonecrosis..  Front Cell Dev Biol,  10  (975879).  [PMID:36187471]
5. Bao Q et al..  (2020)  Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis..  Elife,  9    [PMID:31934850]
6. Yu C et al..  (2015)  Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice..  Am J Physiol Heart Circ Physiol,  308  (5): (H386-97).  [PMID:25527773]
7. Sysoeva VY et al..  (2017)  Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor..  Stem Cell Res,  25  (115-122).  [PMID:29127873]
8. Li Q et al..  (2018)  Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism..  Cell Mol Life Sci,  75  (21): (4021-4040).  [PMID:29916093]
9. Guo J et al..  (2022)  Metformin protects against abdominal aortic aneurysm by Atg7-induced autophagy..  Adv Clin Exp Med,  31  (59-69).  [PMID:34714980]
10. Wang Z et al..  (2019)  Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE-/- mice..  Cell Biosci,  9  (68).  [PMID:31467666]
11. Wang D et al..  (2022)  Quercetin inhibits angiotensin II-induced vascular smooth muscle cell proliferation and activation of JAK2/STAT3 pathway: A target based networking pharmacology approach..  Front Pharmacol,  13  (1002363).  [PMID:36324691]
12. Yang L et al..  (2016)  Silencing of hypoxia inducible factor-1a gene attenuated angiotensin ?-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice..  Atherosclerosis,  252  (40-49).  [PMID:27497884]
13. Xue H et al..  (2022)  RIP3 Contributes to Cardiac Hypertrophy by Influencing MLKL-Mediated Calcium Influx..  Oxid Med Cell Longev,  2022  (5490553).  [PMID:35464769]
14. Duan J et al..  (2019)  The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses..  Nat Commun,  10  (2299).  [PMID:31127110]
15. Yang S et al..  (2019)  The role of STAT3/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells..  Cell Signal,  53  (327-338).  [PMID:30389500]

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