Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A137017-200mg | 200mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $21.90 | |
A137017-1g | 1g | In stock | $84.90 | |
A137017-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $292.90 |
AMPA receptor potentiator
Synonyms | ANIRACETAM [JAN] | aniracetam;p-methoxybenzoyl-2-pirrolidone | CAS-72432-10-1 | HMS501E05 | NCGC00021402-02 | 1-(4-Methoxybenzoyl)-2-pyrrolidinone | AB04115 | Ampamet | ANIRACETAM [MI] | BRN 4807205 | KBio3_002526 | NCGC00015116-13 | NCGC00021402-05 | ani |
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Specifications & Purity | Moligand™, ≥98%(GC) |
Biochemical and Physiological Mechanisms | Nootropic, positive allosteric modulator of AMPA receptors. Slows AMPA receptor deactivation and desensitisation. Antidpressant and anxiolytic in vivo . |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of GluA1;Allosteric modulator of GluA2;Allosteric modulator of GluA3;Allosteric modulator of GluA4 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Aniracetam has modulatory actions through allosteric potentiation of reduction of glutamate receptor desensitization, AMPA specific receptors, and potentiation of metabotropic glutamate receptor activity. AMPA is a transmembrane glutamate receptor composed of the subunits GluR-1,2,3,4. |
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Pubchem Sid | 488179674 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488179674 |
IUPAC Name | 1-(4-methoxybenzoyl)pyrrolidin-2-one |
INCHI | InChI=1S/C12H13NO3/c1-16-10-6-4-9(5-7-10)12(15)13-8-2-3-11(13)14/h4-7H,2-3,8H2,1H3 |
InChi Key | ZXNRTKGTQJPIJK-UHFFFAOYSA-N |
Canonical SMILES | COC1=CC=C(C=C1)C(=O)N2CCCC2=O |
Isomeric SMILES | COC1=CC=C(C=C1)C(=O)N2CCCC2=O |
WGK Germany | 2 |
RTECS | UY5781900 |
PubChem CID | 2196 |
Molecular Weight | 219.24 |
Reaxy-Rn | 4807205 |
DrugBank Ligand | DB04599 |
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Wikipedia | Aniracetam |
CAS Registry No. | 72432-10-1 |
PubChem CID | 2196 |
ChEMBL Ligand | CHEMBL36994 |
RCSB PDB Ligand | 4MP |
DrugCentral Ligand | 221 |
PubChem SID | 488179674 |
Enter Lot Number to search for COA:
Solubility | Soluble in water (<1 mg/ml at 25° C), ethanol (25 mM), DMSO (100 mM), chloroform (50 mg/ml), and methanol. |
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Melt Point(°C) | 122 °C |
Pictogram(s) | GHS08 |
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Signal | Warning |
Hazard Statements | H361:Suspected of damaging fertility or the unborn child |
Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. |
WGK Germany | 2 |
RTECS | UY5781900 |
Reaxy-Rn | 4807205 |
Merck Index | 662 |
1. Nakamura K, Kurasawa M. (2001) Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.. Eur J Pharmacol, 420 (1): (33-43). [PMID:11412837] |
2. Ito I, Tanabe S, Kohda A, Sugiyama H. (1990) Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.. J Physiol (Lond.), 424 (3): (533-43). [PMID:1975272] |