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apararenone - 97%, high purity , CAS No.945966-46-1, Antagonist of Mineralocorticoid receptor

Moligand™
≥97%

CAS#: 945966-46-1
Formula: C₁₇H₁₇FN₂O₄S
Molecular Weight: 364.4
PubChem CID: 24744336

Item Number

A607676

Grouped product items
SKU	Size	Availability	Price
A607676-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$16.90
A607676-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
A607676-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$79.90
A607676-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90
A607676-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$179.90

View related series

Mineralocorticoid receptor Antagonist

Basic Description

Synonyms	945966-46-1\|MT-3995\|N-(4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide\|CHEMBL2181929\|MT3995\|832663U2NB\|N-(4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)methanesulfonamide\|Methanes
Specifications & Purity	Moligand™, ≥97%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of Mineralocorticoid receptor
Product Description	Apararenone (MT-3995) is a novel non-steroidal mineralocorticoid receptor antagonists under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis.

Associated Targets

NR3C1 Tclin Glucocorticoid receptor 0 Activities

Discover Target: NR3C1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ESR2 Tclin Estrogen receptor beta 0 Activities

Discover Target: ESR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NR3C2 Tclin Mineralocorticoid receptor 0 Activities

Discover Target: NR3C2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen receptor 0 Activities

Discover Target: AR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	N-[4-(4-fluorophenyl)-2,2-dimethyl-3-oxo-1,4-benzoxazin-7-yl]methanesulfonamide
INCHI	InChI=1S/C17H17FN2O4S/c1-17(2)16(21)20(13-7-4-11(18)5-8-13)14-9-6-12(10-15(14)24-17)19-25(3,22)23/h4-10,19H,1-3H3
InChi Key	AZNHWXAFPBYFGH-UHFFFAOYSA-N
Canonical SMILES	CC1(C(=O)N(C2=C(O1)C=C(C=C2)NS(=O)(=O)C)C3=CC=C(C=C3)F)C
Isomeric SMILES	CC1(C(=O)N(C2=C(O1)C=C(C=C2)NS(=O)(=O)C)C3=CC=C(C=C3)F)C
PubChem CID	24744336
Molecular Weight	364.4

PubChem CID

CAS Registry No.

ChEMBL Ligand

BindingDB Ligand

DrugBank Ligand

Certificates

Certificate of Analysis(COA)

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9 results found

Lot Number	Certificate Type	Date	Item
G2411585	Certificate of Analysis	Apr 02, 2024	A607676
G2411601	Certificate of Analysis	Apr 02, 2024	A607676
G2411602	Certificate of Analysis	Apr 02, 2024	A607676
G2411606	Certificate of Analysis	Apr 02, 2024	A607676
G2411618	Certificate of Analysis	Apr 02, 2024	A607676
G2411621	Certificate of Analysis	Apr 02, 2024	A607676
G2411622	Certificate of Analysis	Apr 02, 2024	A607676
G2411623	Certificate of Analysis	Apr 02, 2024	A607676
G2411624	Certificate of Analysis	Apr 02, 2024	A607676

References

1. Iijima T, Katoh M, Takedomi K, Yamamoto Y, Akatsuka H, Shirata N, Nishi A, Takakuwa M, Watanabe Y, Munakata H et al.. (2022) Discovery of Apararenone (MT-3995) as a Highly Selective, Potent, and Novel Nonsteroidal Mineralocorticoid Receptor Antagonist.. J Med Chem, 65 (12): (8127-8143). [PMID:35652647]

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