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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Product Name | APC 366, CAS No.158921-85-8 |
|---|---|
| Synonyms | N-[1-hydroxy-2-naphthoyl]-l-arginyl-l-prolinamide | APC 366 (hydrochloride) | BOSAPTLE0I | L-Prolinamide, N2-((1-hydroxy-2-naphthalenyl)carbonyl)-L-arginyl- | (2S)-1-[(2S)-5-(diaminomethylideneamino)-2-[(1-hydroxynaphthalene-2-carbonyl)amino]pentanoyl]pyr |
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Selective inhibitor of mast cell tryptase (Ki= 7.1μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsivenessin vivo. |
| Sequence | N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide |
Associated Targets(Human)
TPSD1 Tbio Tryptase delta (0 Activities)
Associated Targets(non-human)
Tryptase (1 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SARS-CoV-2 (38078 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Product Specifications
| Storage Temp | Store at -20°C |
|---|---|
| Shipped In | Ice chest + Ice pads |
| CAS | 158921-85-8 |
Certificates
Certificate of Analysis(COA)
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