Aphidicolin, Ready Made Solution - from Nigrospora sphaerica, high purity , CAS No.38966-21-1

  • from Nigrospora sphaerica
Item Number
A477631
Grouped product items
SKUSizeAvailabilityPrice Qty
A477631-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$345.90

Basic Description

SynonymsBRN 4689958 | KBioGR_000158 | SMR000058538 | (+/-)-Aphidicolin | ACon1_000511 | DTXSID5036711 | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol | 6B3F8QW8TU | Bio2_000638 | C20H34O4 | HMS1791H20 | ne-
Specifications & Purityfrom Nigrospora sphaerica
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Description

Aphidicolin is a tetracyclic diterpene with antiviral and antimitotic properties used for cell cycle synchronization in various cell lines.Aphidicolin, fromNigrospora sphaerica, was used for cell cycle synchronization of tobacco BY-2 cells. It is used to block the entry of cells into S-phase.


Preparation instructions



Form

Aphidicolin Ready Made Solution supplied as a 1 mg/ml solution in DMSO.


Principle


Associated Targets(Human)

POLA1 Tclin DNA polymerase alpha subunit (225 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLB Tchem DNA polymerase beta (23632 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLD1 Tclin DNA polymerase delta subunit 1 (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLG Tchem DNA polymerase gamma subunit 1 (50 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BJ (6930 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HFF (3142 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HIF1A Tchem Hypoxia-inducible factor 1 alpha (6027 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL (112 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLL Tbio DNA polymerase lambda (184 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTT Tchem Huntingtin (19182 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMN1 Tchem Survival motor neuron protein (34246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
LMNA Tbio Prelamin-A/C (36751 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RECQL Tbio ATP-dependent DNA helicase Q1 (5575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Human herpesvirus 1 DNA polymerase (160 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
UL54 Human herpesvirus 5 DNA polymerase (104 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U38 Human herpesvirus 6 DNA polymerase (36 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chlamydia pneumoniae (241 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human alphaherpesvirus 1 (11089 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DNA polymerase (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DNA polymerase catalytic subunit (5 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name (1S,2S,5R,6R,7R,10S,12R,13R)-6,13-bis(hydroxymethyl)-2,6-dimethyltetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol
INCHI InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1
InChi Key NOFOAYPPHIUXJR-APNQCZIXSA-N
Canonical SMILES CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
Isomeric SMILES C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
WGK Germany 3
RTECS PB9185000
PubChem CID 457964
Molecular Weight 338.48
Beilstein 4689958

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Chemical and Physical Properties

Solubility H2O: miscible (completely)

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS PB9185000

Related Documents

Citations of This Product

1. Wensen Zhang, Na Cui, Fazhi Su, Yanping Sun, Biao Li, Yupeng Ren, Ping Wang, Haodong Bai, Wei Guan, Bingyou Yang, Qiuhong Wang, Haixue Kuang.  (2023)  Serum, spleen metabolomics and gut microbiota reveals effect of catalpol on blood deficiency syndrome caused by cyclophosphamide and acetylphenylhydrazine.  Frontiers in Immunology,  14  (29): (1280049).  [PMID:38022670] [10.3389/fimmu.2023.1280049]
2. Wang Juan, Wang Furong, Yuan Lixia, Ruan Hongsheng, Zhu Zhibiao, Fan Xiaoling, Zhu Lingyan, Peng Xin.  (2022)  Blood-Enriching Effects and Immune-Regulation Mechanism of Steam-Processed Polygonatum Sibiricum Polysaccharide in Blood Deficiency Syndrome Mice.  Frontiers in Immunology,  13    [PMID:35250989] [10.3389/fimmu.2022.813676]

References

1. S Spadari,F Focher,F Sala,G Ciarrocchi,G Koch,A Falaschi,G Pedrali-Noy.  (1985-01-01)  Control of cell division by aphidicolin without adverse effects upon resting cells..  Arzneimittel-Forschung,  35  ((7)): (1108-1116).  [PMID:3931652]
2. S Seki,T Oda,M Ohashi.  (1980-12-11)  Differential effects of aphidicolin on replicative DNA synthesis and unscheduled DNA synthesis in permeable mouse sarcoma cells..  Biochimica et biophysica acta,  610  ((2)): (413-420).  [PMID:6783076]
3. W A Kues,M Anger,J W Carnwath,D Paul,J Motlik,H Niemann.  (2000-01-22)  Cell cycle synchronization of porcine fetal fibroblasts: effects of serum deprivation and reversible cell cycle inhibitors..  Biology of reproduction,  62  ((2)): (412-419).  [PMID:10642581]
4. Varinderpal S Dhillon,Syed Akhtar Husain,G N Ray.  (2003-03-05)  Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients..  Teratogenesis, carcinogenesis, and mutagenesis,    (35-45).  [PMID:12616595]
5. Klára Hofstetrová,Magdalena Uzlíková,Pavla Tůmová,Karin Troell,Staffan G Svärd,Eva Nohýnková.  (2009-09-09)  Giardia intestinalis: aphidicolin influence on the trophozoite cell cycle..  Experimental parasitology,  124  ((2)): (159-166).  [PMID:19735659]
6. Cheng Wan,Atul Kulkarni,Yuh-Hwa Wang.  (2010-01-12)  ATR preferentially interacts with common fragile site FRA3B and the binding requires its kinase activity in response to aphidicolin treatment..  Mutation research,  686  ((1-2)): (39-46).  [PMID:20060399]
7. Anne Letessier,Daniel Birnbaum,Michelle Debatisse,Max Chaffanet.  (2011-09-02)  [Genome: does a paucity of initiation events lead to fragility?]..  Medecine sciences : M/S,  27  ((8-9)): (707-709).  [PMID:21880257]
8. Ryuya Fujii,Atsushi Minami,Tae Tsukagoshi,Natsuko Sato,Takehiko Sahara,Satoru Ohgiya,Katsuya Gomi,Hideaki Oikawa.  (2011-09-08)  Total biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase α: heterologous expression of four biosynthetic genes in Aspergillus oryzae..  Bioscience, biotechnology, and biochemistry,  75  ((9)): (1813-1817).  [PMID:21897020]
9. Kenjiro Asagoshi,Wade Lehmann,Elena K Braithwaite,Lucas Santana-Santos,Rajendra Prasad,Jonathan H Freedman,Bennett Van Houten,Samuel H Wilson.  (2011-09-16)  Single-nucleotide base excision repair DNA polymerase activity in C. elegans in the absence of DNA polymerase β..  Nucleic acids research,  40  ((2)): (670-681).  [PMID:21917855]
10. Laetitia Finzi,Aurore Kraemer,Claude Capron,Severine Noullet,Diane Goere,Christophe Penna,Bernard Nordlinger,Josette Legagneux,Jean-Fançois Emile,Robert Malafosse.  (2011-10-06)  Improved retroviral suicide gene transfer in colon cancer cell lines after cell synchronization with methotrexate..  Journal of experimental & clinical cancer research : CR,  30  (92-92).  [PMID:21970612]
11. Takuma Kanesaki,Carina M Edwards,Ulrich S Schwarz,Jörg Grosshans.  (2011-10-18)  Dynamic ordering of nuclei in syncytial embryos: a quantitative analysis of the role of cytoskeletal networks..  Integrative biology : quantitative biosciences from nano to macro,  ((11)): (1112-1119).  [PMID:22001900]
12. Arkarachai Fungtammasan,Erin Walsh,Francesca Chiaromonte,Kristin A Eckert,Kateryna D Makova.  (2012-03-30)  A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?.  Genome research,  22  ((6)): (993-1005).  [PMID:22456607]
13. Rachid Amsailale,Eric Van Den Neste,Angélique Arts,Eliza Starczewska,Françoise Bontemps,Caroline Smal.  (2012-04-12)  Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells..  Biochemical pharmacology,  84  ((1)): (43-51).  [PMID:22490700]
14. T Katherine Tamai,Lucy C Young,Catherine A Cox,David Whitmore.  (2012-06-02)  Light acts on the zebrafish circadian clock to suppress rhythmic mitosis and cell proliferation..  Journal of biological rhythms,  27  ((3)): (226-236).  [PMID:22653891]
15. Artem K Velichko,Nadezhda V Petrova,Omar L Kantidze,Sergey V Razin.  (2012-07-13)  Dual effect of heat shock on DNA replication and genome integrity..  Molecular biology of the cell,  23  ((17)): (3450-3460).  [PMID:22787276]
16. Stephan Heermann,Björn Spittau,Katalin Zajzon,Markus H Schwab,Kerstin Krieglstein.  (2012-08-07)  Schwann cells migrate along axons in the absence of GDNF signaling..  BMC neuroscience,  13  (92-92).  [PMID:22863354]
17. Akira Kikuchi,Masashi Asahina,Motoki Tanaka,Shinobu Satoh,Hiroshi Kamada.  (2012-08-11)  Acquisition of embryogenic competency does not require cell division in carrot somatic cell..  Journal of plant research,  126  ((2)): (243-250).  [PMID:22878456]
18. Alba Llopis,Noelia Salvador,Amaia Ercilla,Sandra Guaita-Esteruelas,Ivan del Barco Barrantes,Jalaj Gupta,Matthias Gaestel,Roger J Davis,Angel R Nebreda,Neus Agell.  (2012-09-01)  The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest..  Cell cycle (Georgetown, Tex.),  11  ((19)): (3627-3637).  [PMID:22935704]
19. Wen Deng,Sai Wah Tsao,Xin-Yuan Guan,Annie L M Cheung.  (2012-11-03)  Pericentromeric regions are refractory to prompt repair after replication stress-induced breakage in HPV16 E6E7-expressing epithelial cells..  PloS one,  ((10)): (e48576-e48576).  [PMID:23119062]
20. Krishna P Kota,Jacqueline G Benko,Rajini Mudhasani,Cary Retterer,Julie P Tran,Sina Bavari,Rekha G Panchal.  (2012-12-04)  High content image based analysis identifies cell cycle inhibitors as regulators of Ebola virus infection..  Viruses,  ((10)): (1865-1877).  [PMID:23202445]
21. Terri G Edwards,Michael J Helmus,Kevin Koeller,James K Bashkin,Chris Fisher.  (2013-02-01)  Human papillomavirus episome stability is reduced by aphidicolin and controlled by DNA damage response pathways..  Journal of virology,  87  ((7)): (3979-3989).  [PMID:23365423]
22. Indrajit Chaudhury,Daniel R Stroik,Alexandra Sobeck.  (2014-08-20)  FANCD2-controlled chromatin access of the Fanconi-associated nuclease FAN1 is crucial for the recovery of stalled replication forks..  Molecular and cellular biology,  34  ((21)): (3939-3954).  [PMID:25135477]
23. Irina A Okkelman,Ruslan I Dmitriev,Tara Foley,Dmitri B Papkovsky.  (2016-12-16)  Use of Fluorescence Lifetime Imaging Microscopy (FLIM) as a Timer of Cell Cycle S Phase..  PloS one,  11  ((12)): (e0167385-e0167385).  [PMID:27973570]
24. Theodore T Ho,Matthew R Warr,Emmalee R Adelman,Olivia M Lansinger,Johanna Flach,Evgenia V Verovskaya,Maria E Figueroa,Emmanuelle Passegué.  (2017-02-28)  Autophagy maintains the metabolism and function of young and old stem cells..  Nature,  543  ((7644)): (205-210).  [PMID:28241143]
25. Judit Espana-Agusti,Anne Warren,Su Kit Chew,David J Adams,Athena Matakidou.  (2017-12-13)  Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis..  Nature communications,  ((1)): (2026-2026).  [PMID:29229903]
26. Henrike Johanna Gothe,Britta Annika Maria Bouwman,Eduardo Gade Gusmao,Rossana Piccinno,Giuseppe Petrosino,Sergi Sayols,Oliver Drechsel,Vera Minneker,Natasa Josipovic,Athanasia Mizi,Christian Friberg Nielsen,Eva-Maria Wagner,Shunichi Takeda,Hiroyuki Sasanuma,Damien Francis Hudson,Thomas Kindler,Laura Baranello,Argyris Papantonis,Nicola Crosetto,Vassilis Roukos.  (2019-06-17)  Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations..  Molecular cell,  75  ((2)): (267-283).  [PMID:31202576]
27. James Kim,Daniel Novak,Christos Sachpekidis,Jochen Utikal,Lionel Larribère.  (2020-01-08)  STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations..  Cancers,  12  ((1)):   [PMID:31906480]
28. M Oguro,C Suzuki-Hori,H Nagano,Y Mano,S Ikegami.  (1979-07-01)  The mode of inhibitory action by aphidicolin on eukaryotic DNA polymerase alpha..  European journal of biochemistry,  97  ((2)): (603-607).  [PMID:467434]
29. S Ikegami,T Taguchi,M Ohashi,M Oguro,H Nagano,Y Mano.  (1978-10-05)  Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-alpha..  Nature,  275  ((5679)): (458-460).  [PMID:692726]
30. H P Zabel,E Holler,J Winter.  (1987-05-15)  Mode of inhibition of the DNA polymerase of Methanococcus vannielii by aphidicolin..  European journal of biochemistry,  165  ((1)): (171-175).  [PMID:3106039]
31. A N Starratt,S R Loschiavo.  (1974-03-01)  The production of aphidicolin by Nigrospora sphaerica..  Canadian journal of microbiology,  20  ((3)): (416-417).  [PMID:4822057]
32. G Pedrali-Noy,S Spadari,A Miller-Faurès,A O Miller,J Kruppa,G Koch.  (1980-01-25)  Synchronization of HeLa cell cultures by inhibition of DNA polymerase alpha with aphidicolin..  Nucleic acids research,  ((2)): (377-387).  [PMID:6775308]
33. J A Huberman.  (1981-03-01)  New views of the biochemistry of eucaryotic DNA replication revealed by aphidicolin, an unusual inhibitor of DNA polymerase alpha..  Cell,  23  ((3)): (647-648).  [PMID:6784928]
34. R Uzbekov,I Chartrain,M Philippe,Y Arlot-Bonnemains.  (1998-07-17)  Cell cycle analysis and synchronization of the Xenopus cell line XL2..  Experimental cell research,  242  ((1)): (60-68).  [PMID:9665802]
35. K Marheineke,O Hyrien.  (2001-03-30)  Aphidicolin triggers a block to replication origin firing in Xenopus egg extracts..  The Journal of biological chemistry,  276  ((20)): (17092-17100).  [PMID:11279043]
36. Anne-Hélène Quélo,John A Bryant,Jean-Pierre Verbelen.  (2002-03-12)  Endoreduplication is not inhibited but induced by aphidicolin in cultured cells of tobacco..  Journal of experimental botany,  53  ((369)): (669-675).  [PMID:11886886]
37. Martin F Arlt,Alev Cagla Ozdemir,Shanda R Birkeland,Thomas E Wilson,Thomas W Glover.  (2011-10-12)  Hydroxyurea induces de novo copy number variants in human cells..  Proceedings of the National Academy of Sciences of the United States of America,  108  ((42)): (17360-17365).  [PMID:21987784]
38. Avik K Ghosh,Marie L Rossi,Dharmendra Kumar Singh,Christopher Dunn,Mahesh Ramamoorthy,Deborah L Croteau,Yie Liu,Vilhelm A Bohr.  (2011-11-01)  RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance..  The Journal of biological chemistry,  287  ((1)): (196-209).  [PMID:22039056]
39. Ting-Yu Zhang,Jian-Jun Dai,Cai-Feng Wu,Xiao-Long Gu,Liang Liu,Zhi-Qiang Wu,Yi-Ni Xie,Bin Wu,Hui-Lan Chen,Yao Li,Xue-Jin Chen,De-Fu Zhang.  (2012-02-22)  Positive effects of treatment of donor cells with aphidicolin on the preimplantation development of somatic cell nuclear transfer embryos in Chinese Bama mini-pig (Sus Scrofa)..  Animal science journal = Nihon chikusan Gakkaiho,  83  ((2)): (103-110).  [PMID:22339690]
40. Martin F Arlt,Thomas E Wilson,Thomas W Glover.  (2012-03-01)  Replication stress and mechanisms of CNV formation..  Current opinion in genetics & development,  22  ((3)): (204-210).  [PMID:22365495]
41. Min Huang,Hui Li,Lu Zhang,Fei Gao,Pu Wang,Yong Hu,Shihan Yan,Lin Zhao,Qi Zhang,Junjun Tan,Xincheng Liu,Shibin He,Lijia Li.  (2012-04-18)  Plant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterations..  PloS one,  ((4)): (e35139-e35139).  [PMID:22509394]
42. Martin F Arlt,Sountharia Rajendran,Shanda R Birkeland,Thomas E Wilson,Thomas W Glover.  (2012-10-03)  De novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining..  PLoS genetics,  ((9)): (e1002981-e1002981).  [PMID:23028374]
43. Seiki Nakao,Sufang Zhang,Markku Vaara,Juhani E Syväoja,Marietta Y Lee,Toshiki Tsurimoto,Peter Karran,Shinya Oda.  (2012-10-16)  Efficient long DNA gap-filling in a mammalian cell-free system: a potential new in vitro DNA replication assay..  Biochimie,  95  ((2)): (320-328).  [PMID:23063694]
44. Günter Speit,Christine Leibiger,Stefanie Kuehner,Josef Högel.  (2012-12-12)  Further investigations on the modified comet assay for measuring aphidicolin-block nucleotide excision repair..  Mutagenesis,  28  ((2)): (145-151).  [PMID:23221037]
45. Nicola Crosetto,Abhishek Mitra,Maria Joao Silva,Magda Bienko,Norbert Dojer,Qi Wang,Elif Karaca,Roberto Chiarle,Magdalena Skrzypczak,Krzysztof Ginalski,Philippe Pasero,Maga Rowicka,Ivan Dikic.  (2013-03-19)  Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing..  Nature methods,  10  ((4)): (361-365).  [PMID:23503052]
46. Piotr Mamczur,Andrzej Gamian,Jerzy Kolodziej,Piotr Dziegiel,Dariusz Rakus.  (2013-07-28)  Nuclear localization of aldolase A correlates with cell proliferation..  Biochimica et biophysica acta,  1833  ((12)): (2812-2822).  [PMID:23886627]
47. Roxane Lestini,Sergey P Laptenok,Joëlle Kühn,Mark A Hink,Marie-Claire Schanne-Klein,Ursula Liebl,Hannu Myllykallio.  (2013-09-21)  Intracellular dynamics of archaeal FANCM homologue Hef in response to halted DNA replication..  Nucleic acids research,  41  ((22)): (10358-10370).  [PMID:24049073]
48. Silvia Alvarez,Marcos Díaz,Johanna Flach,Sara Rodriguez-Acebes,Andrés J López-Contreras,Dolores Martínez,Marta Cañamero,Oscar Fernández-Capetillo,Joan Isern,Emmanuelle Passegué,Juan Méndez.  (2015-10-13)  Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality..  Nature communications,  (8548-8548).  [PMID:26456157]
49. Hui Wang,Thorsten Schaefer,Martina Konantz,Martin Braun,Zsuzsanna Varga,Anna M Paczulla,Selina Reich,Francis Jacob,Sven Perner,Holger Moch,Tanja N Fehm,Lothar Kanz,Klaus Schulze-Osthoff,Claudia Lengerke.  (2017-02-18)  Prominent Oncogenic Roles of EVI1 in Breast Carcinoma..  Cancer research,  77  ((8)): (2148-2160).  [PMID:28209621]
50. Olha M Koval,Emily K Nguyen,Velarchana Santhana,Trevor P Fidler,Sara C Sebag,Tyler P Rasmussen,Dylan J Mittauer,Stefan Strack,Prabhat C Goswami,E Dale Abel,Isabella M Grumbach.  (2019-05-02)  Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation..  Science signaling,  12  ((579)):   [PMID:31040260]
51. Wensen Zhang, Na Cui, Fazhi Su, Yanping Sun, Biao Li, Yupeng Ren, Ping Wang, Haodong Bai, Wei Guan, Bingyou Yang, Qiuhong Wang, Haixue Kuang.  (2023)  Serum, spleen metabolomics and gut microbiota reveals effect of catalpol on blood deficiency syndrome caused by cyclophosphamide and acetylphenylhydrazine.  Frontiers in Immunology,  14  (29): (1280049).  [PMID:38022670] [10.3389/fimmu.2023.1280049]
52. Wang Juan, Wang Furong, Yuan Lixia, Ruan Hongsheng, Zhu Zhibiao, Fan Xiaoling, Zhu Lingyan, Peng Xin.  (2022)  Blood-Enriching Effects and Immune-Regulation Mechanism of Steam-Processed Polygonatum Sibiricum Polysaccharide in Blood Deficiency Syndrome Mice.  Frontiers in Immunology,  13    [PMID:35250989] [10.3389/fimmu.2022.813676]

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