Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A106675-20mg | 20mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $58.90 | |
A106675-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $218.90 | |
A106675-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $874.90 |
Anticancer agent
Synonyms | Chamomile | Apigenine | Versulin | 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one | C.I. Natural Yellow 1 | 5,7,4'-Trihydroxyflavone | Apigenol | 4',5,7-Trihydroxyflavone | Pelargidenon 1449 | Spigenin |
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Specifications & Purity | Moligand™, analytical standard, ≥98% |
Biochemical and Physiological Mechanisms | Plant flavone. Antioxidant, anti-inflammatory and anticancer properties. Effects a wide range of molecular targets including caspases, fatty acid synthase, topoisomerase and nuclear factor-κB. |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Grade | analytical standard, Moligand™ |
Action Type | ACTIVATOR |
Mechanism of action | Activator of CFTR |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
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IUPAC Name | 5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one |
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INCHI | InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H |
InChi Key | KZNIFHPLKGYRTM-UHFFFAOYSA-N |
Canonical SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O |
Isomeric SMILES | C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O |
WGK Germany | 3 |
RTECS | LK9276000 |
PubChem CID | 5280443 |
Molecular Weight | 270.24 |
Beilstein | 262620 |
Reaxy-Rn | 262620 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
B2423370 | Certificate of Analysis | Jan 18, 2024 | A106675 |
L2109455 | Certificate of Analysis | Sep 21, 2023 | A106675 |
C2329721 | Certificate of Analysis | Feb 16, 2023 | A106675 |
C2329722 | Certificate of Analysis | Feb 16, 2023 | A106675 |
C2329723 | Certificate of Analysis | Feb 16, 2023 | A106675 |
C2329725 | Certificate of Analysis | Feb 16, 2023 | A106675 |
C2329726 | Certificate of Analysis | Feb 16, 2023 | A106675 |
C2329727 | Certificate of Analysis | Feb 16, 2023 | A106675 |
B2318468 | Certificate of Analysis | Nov 24, 2021 | A106675 |
Sensitivity | Light sensitive. |
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Melt Point(°C) | 345-350°C |
Pictogram(s) | GHS07 |
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Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
WGK Germany | 3 |
RTECS | LK9276000 |
Reaxy-Rn | 262620 |
Merck Index | 730 |
1. Ziyuan Deng, Chengling Lai, Jun Zhang, Fan Sun, Danting Li, Peiying Hao, Xuping Shentu, Kun Pang, Xiaoping Yu. (2024) Effects of Secondary Metabolites of Rice on Brown Planthopper and Its Symbionts. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 25 (1): (386). [PMID:38203556] |
2. Jingjing Zhen, Faguang Ma, Jing Yan, Rongxin Lin, Ming Yan, Yilin Wu. (2024) Synthesis of metal-organic framework hybrid nanocomposites based on MOFs@C3N4 with high selective separation ability for luteolin. SEPARATION AND PURIFICATION TECHNOLOGY, 335 (126139). [PMID:] |
3. Shucheng Liu, Zhi Hu, Xuan Zhang, Hao Huang, Jianming Pan, Hongxiang Ou. (2024) Fabrication of double imprinted anchor points in cellulose nanocrystals-based hierarchical porous polyHIPEs for selective separation of flavoniods under physiological pH. JOURNAL OF HAZARDOUS MATERIALS, 465 (133230). [PMID:38134695] |
4. Yueqin Li, Yunzhen Zhang, Lezhen Dong, Ying Li, Yahui Liu, Yang Liu, Lingyi Liu, Lianliang Liu. (2024) Fermentation of Lactobacillus fermentum NB02 with feruloyl esterase production increases the phenolic compounds content and antioxidant properties of oat bran. FOOD CHEMISTRY, 437 (15): (137834). [PMID:37897817] |
5. Dan Wang, He Li, Tian-Yu Hou, Zhi-Jun Zhang, Hui-Zhen Li. (2023) Effects of conjugated interactions between Perilla seed meal proteins and different polyphenols on the structural and functional properties of proteins. FOOD CHEMISTRY, (137345). [PMID:37666124] |
6. Mingcai Ma, Xiaofeng Lu, Licheng Wang, Yong Guo, Hui Ding, Shuai Wang, Xiaojing Liang. (2023) A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids. JOURNAL OF CHROMATOGRAPHY A, 1707 (464324). [PMID:37634259] |
7. Shuang Xiao, Peng Zhang, Guowen Zhang, Wenwen Li, Haowen Lin, Xing Hu. (2023) Inhibition of toll-like receptor 4 activation by apigenin and chrysin via competition for sites and conformational changes. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 252 (126415). [PMID:37598817] |
8. Dan Chen, Wenjing Wang, Qingxia Zhu, Qinya Wang, Daoyi Quan, Yun Zeng, Ke Li, Yun Zhou, Changhu Liu, Wenhua Zhan, Yonghua Zhan. (2023) In vivo real-time monitoring of the development of hypoxia and angiogenesis in cervical cancer. CHEMICAL ENGINEERING JOURNAL, 473 (145498). [PMID:] |
9. Feng Tao, Pucker Boas, Kuang Tianhui, Song Bo, Yang Ya, Lin Nan, Zhang Huajie, Moore Michael J., Brockington Samuel F., Wang Qingfeng, Deng Tao, Wang Hengchang, Sun Hang. (2023) The genome of the glasshouse plant noble rhubarb (Rheum nobile) provides a window into alpine adaptation. Communications Biology, 6 (1): (1-15). [PMID:37429977] |
10. Haihui Wang, Yifan Jiang, Yichang Liu, Xiaohui Zhu, Yongfei Liu, Minle Chen, Tao Zeng, Zhaowei Chen, Jinyu Li, Chunhua Lu, Huanghao Yang. (2023) 2′-Fluoro-substituted DNA-induced self-assembly strategy for engineering hybrid nanospheres. CHEMICAL ENGINEERING JOURNAL, 471 (144411). [PMID:] |
11. Chang Liu, Xiao Guo, Yutong Chen, Meijun Zhao, Shuai Shi, Zheng Luo, Jian Song, Zhihong Zhang, Wenchuang Yang, Keyi Liu. (2023) Anti-photoaging effect and mechanism of flexible liposomes co-loaded with apigenin and doxycycline. BIOMEDICINE & PHARMACOTHERAPY, 164 (114998). [PMID:37301137] |
12. Xu Yang-ding, Guo Yu-jie, Mao He-rong, Xiong Zhi-xiang, Luo Meng-yu, Luo Rui-qi, Lu Shan, Huang Lu, Hong Yi. (2023) Integration of transcriptomics and proteomics to elucidate inhibitory effect and mechanism of rosmarinic acid from Perilla frutescens (L.) Britt. in treating Trichophyton mentagrophytes. Chinese Medicine, 18 (1): (1-20). [PMID:37280712] |
13. Jingtong Xia, Jiahao Zhou, Yanlong Liu, Na Yan, Xiaowen Hu, Lei Zhou, Qiaosheng Pu. (2023) Non-destructive distinction of single seed for Medicago sativa and Melilotus officinalis by capillary electrophoresis with laser-induced fluorescence detection. JOURNAL OF CHROMATOGRAPHY A, 1704 (464116). [PMID:37290349] |
14. Dongwei Wei, Wuyong Sun, Mingren Huang, Xiaoning Zeng, Yun Chen, Zhiliang Yuan. (2023) Phenolic Characterization and Antioxidant Activity of Chrysanthemum indicum and Opisthopappus Shih during Different Growth Stages. CHEMISTRY & BIODIVERSITY, 20 (7): (e202300370). [PMID:37263981] |
15. Zhifeng Cai, Yi Zhang, Meiling Jin, Meiling Hao, Huijuan Yang, Yang Peng, Jingwen Lu, Yaofang Zhang, Jiaxu Dong, Jiali Ren, Ran Zhang, Ya Wang. (2023) Preparation of blue fluorescent copper nanoclusters for sensitive and selective sensing of apigenin in pharmaceutical samples. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 300 (122940). [PMID:37267837] |
16. Jie Li, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang, Shumao Cui. (2023) Protective Effects of Naringenin and Apigenin in Ameliorating Skin Damage via Mediating the Nrf2 and NF-κB Pathways in Mice. Foods, 12 (11): (2120). [PMID:37297362] |
17. Shaoyan Zhang, Jinfeng Ning, Qingqing Wang, Wei Wang. (2023) Fluorescence enhancement of flavonoids and its application in ingredient determination for some traditional Chinese medicines by CE-LIF. Analytical Methods, 15 (24): (2964-2970). [PMID:37309583] |
18. Lei He, Qian Hu, Liyang Wei, Xuliyang Ge, Ning Yu, Ying Chen. (2023) Unravelling dynamic changes in non-volatile and volatile metabolites of pulses during soaking: An integrated metabolomics approach. FOOD CHEMISTRY, 422 (136231). [PMID:37141754] |
19. Xueyan Ji, Wei Du, Wenqing Che, Liping Wang, Lu Zhao. (2023) Apigenin Inhibits the Progression of Osteoarthritis by Mediating Macrophage Polarization. MOLECULES, 28 (7): (2915). [PMID:37049677] |
20. Jia Gao, Li Chen, Wendong Xing, Chao Yu, Yongsheng Yan, Yilin Wu. (2023) “Nanomagnet-inspired” design on molecularly imprinted nanofiber membrane: Mechanisms for improved transport selectivity of sufficient specific sites. JOURNAL OF MEMBRANE SCIENCE, 672 (121467). [PMID:] |
21. Jinying Guo, Chuanfa Gan, Bo Cheng, Bo Cui, Fankai Yi. (2023) Exploration of binding mechanism of apigenin to pepsin: Spectroscopic analysis, molecular docking, enzyme activity and antioxidant assays. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 290 (122281). [PMID:36584639] |
22. Mang-Mang Li, Yi-Ting Chen, Jin-Cang Ruan, Wen-Jun Wang, Ji-Guang Chen, Qing-Feng Zhang. (2023) Structure-activity relationship of dietary flavonoids on pancreatic lipase. Current Research in Food Science, 6 (100424). [PMID:36618100] |
23. Fengxia Tang, Chuan Li, Xiaoran Yang, Jiandu Lei, Hongxia Chen, Changwei Zhang, Chengzhang Wang. (2023) Effect of Variety and Maturity Index on the Physicochemical Parameters Related to Virgin Olive Oil from Wudu (China). Foods, 12 (1): (7). [PMID:36613224] |
24. Xijuan Tu, Fengjie Yu, Qian Jin, Chunping Du, Jiaxu Chen, Ji Yang, Yuchang He, Shaokang Huang, Wenbin Chen. (2022) A Simple High-Throughput Field Sample Preparation Method Based on Matrix-Induced Sugaring-Out for the Simultaneous Determination of 5-Hydroxymethylfurfural and Phenolic Compounds in Honey. MOLECULES, 27 (23): (8373). [PMID:36500464] |
25. Fuqiang Liang, Yumeng Shi, Jiayi Shi, WeiWei Cao. (2023) Exploring the binding mechanism of pumpkin seed protein and apigenin: Spectroscopic analysis, molecular docking and molecular dynamics simulation. FOOD HYDROCOLLOIDS, 137 (108318). [PMID:] |
26. Lingli Zhao, Mengfei Zheng, Hao Cai, Juan Chen, Yan Lin, Fangbin Wang, Lu Wang, Xian Zhang, Jian Liu. (2023) The activity comparison of six dietary flavonoids identifies that luteolin inhibits 3T3-L1 adipocyte differentiation through reducing ROS generation. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 112 (109208). [PMID:36370929] |
27. Dan Yu, Fei Liu, Changdong Zou, Xiao Yang. (2023) Municipal green waste promotes iron release from steelmaking slag in water. RESOURCES CONSERVATION AND RECYCLING, 188 (106722). [PMID:] |
28. Nabipour Hafezeh, Wang Xin, Song Lei, Hu Yuan. (2022) Intrinsically Anti-Flammable Apigenin-derived Epoxy Thermosets with High Glass Transition Temperature and Mechanical Strength. CHINESE JOURNAL OF POLYMER SCIENCE, 40 (10): (1259-1268). [PMID:] |
29. Jia Gao, Qingyan Guo, Yan Yan, Chao Yu, Muning Chen, Wendong Xing, Li Yan, Yongsheng Yan, Yilin Wu. (2022) Templating precise multiple binding sites: Promising molecularly imprinted membrane orchestrated by sequential surface imprinting strategy. CHEMICAL ENGINEERING JOURNAL, 450 (138058). [PMID:] |
30. Tingxuan Yan, Haili Wang, Xingfang Song, Tingyuan Yan, Yuwen Ding, Kang Luo, Juan Zhen, Gui He, Libin Nian, Shuangshou Wang, Zhixiang Wang. (2022) Fabrication of apigenin nanoparticles using antisolvent crystallization technology: A comparison of supercritical antisolvent, ultrasonic-assisted liquid antisolvent, and high-pressure homogenization technologies. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 624 (121981). [PMID:35792228] |
31. Ren Chuanhong, Guo Yan, Xie Linfeng, Zhao Zhikang, Xing Mengyun, Cao Yunlin, Liu Yilong, Lin Jing, Grierson Donald, Zhang Bo, Xu Changjie, Chen Kunsong, Li Xian. (2022) Identification of UDP-rhamnosyltransferases and UDP-galactosyltransferase involved in flavonol glycosylation in Morella rubra. Horticulture Research, 9 [PMID:36072838] |
32. Xiaoli Wang, Jichen Yang, Huan Li, Se Shi, Xin Peng. (2022) Mechanistic study and synergistic effect on inhibition of α-amylase by structurally similar flavonoids. JOURNAL OF MOLECULAR LIQUIDS, 360 (119485). [PMID:] |
33. Dongxu Han, Yujie Yao, Lu Chen, Zhiying Miao, Shiwen Xu. (2022) Apigenin ameliorates di(2-ethylhexyl) phthalate-induced ferroptosis: The activation of glutathione peroxidase 4 and suppression of iron intake. FOOD AND CHEMICAL TOXICOLOGY, 164 (113089). [PMID:35500696] |
34. Yihua Shi, Kai Lian, Jiguang Jia. (2022) Apigenin Suppresses the Warburg Effect and Stem-like Properties in SOSP-9607 Cells by Inactivating the PI3K/Akt/mTOR Signaling Pathway. Evidence-based Complementary and Alternative Medicine, 2022 (3983637). [PMID:35310040] |
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36. Fuqiang Liang, Yumeng Shi, Weiwei Cao, Jiayi Shi. (2022) The inhibition mechanisms of pancreatic lipase by apigenin and its anti-obesity mechanisms revealed by using network pharmacology. Food Bioscience, 45 (101515). [PMID:] |
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34. Dongxu Han, Yujie Yao, Lu Chen, Zhiying Miao, Shiwen Xu. (2022) Apigenin ameliorates di(2-ethylhexyl) phthalate-induced ferroptosis: The activation of glutathione peroxidase 4 and suppression of iron intake. FOOD AND CHEMICAL TOXICOLOGY, 164 (113089). [PMID:35500696] |
35. Yihua Shi, Kai Lian, Jiguang Jia. (2022) Apigenin Suppresses the Warburg Effect and Stem-like Properties in SOSP-9607 Cells by Inactivating the PI3K/Akt/mTOR Signaling Pathway. Evidence-based Complementary and Alternative Medicine, 2022 (3983637). [PMID:35310040] |
36. Fan Wu, Fulin Tian, Zhou Jin, Jing Liu, Weiping Jin, Xuan Chen, Zhan Wang, Xiwu Jia, Benguo Liu, Lingyi Liu, Wangyang Shen. (2022) Antioxidant capacities of heat-treated wheat germ and extruded compounded bran. CEREAL CHEMISTRY, 99 (3): (582-592). [PMID:] |
37. Fuqiang Liang, Yumeng Shi, Weiwei Cao, Jiayi Shi. (2022) The inhibition mechanisms of pancreatic lipase by apigenin and its anti-obesity mechanisms revealed by using network pharmacology. Food Bioscience, 45 (101515). [PMID:] |