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Apixaban - ≥99%, high purity , Coagulation factor X inhibitor, CAS No.503612-47-3, Coagulation factor X inhibitor
Basic Description Synonyms Apixaban|503612-47-3|Eliquis|BMS-562247-01|BMS-562247|BMS 562247-01|1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide|apixabanum|1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phen Specifications & Purity Moligand™, ≥99% Biochemical and Physiological Mechanisms Apixaban(BMS-562247-01; BMS 562247-01) is a direct factor Xa inhibitor with an IC50 of 0.22±0.02 μM. Apixaban is a compound being investigated as an anticoagulant. Apixaban (BMS-562247-01; BMS 562247-01)has similar affinity for
Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Coagulation factor X inhibitor Product Description Apixaban is a highly selective, reversible inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively. Apixaban is in development for the prevention and treatment of various thromboembolic diseases.
Names and Identifiers Pubchem Sid 488196571 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196571 IUPAC Name 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide INCHI InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32) InChi Key QNZCBYKSOIHPEH-UHFFFAOYSA-N Canonical SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N Isomeric SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N Alternate CAS 503612-47-3 PubChem CID 10182969 MeSH Entry Terms apixaban;BMS 562247;BMS-562247;BMS-562247-01;BMS562247;Eliquis Molecular Weight 459.51
Chemical and Physical Properties Solubility DMSO 18 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Danger Hazard Statements H373: Causes damage to organs through prolonged or repeated exposure
H372: Causes damage to organs through prolonged or repeated exposure
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P260: Do not breathe dust/fume/gas/mist/vapors/spray.
P270: Do not eat, drink or smoke when using this product.
P319: Get medical help if you feel unwell.
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