Apoptolidin - >95%, high purity , CAS No.194874-06-1

Item Number

A329643

• Synonyms: UNII-SAO6WVQ23I | HY-126679 | Apoptolidin | FU-40A | (3~{E},5~{E},7~{E},9~{R},10~{R},11~{E},13~{E},17~{S},18~{S},20~{S})-18-methoxy-20-[(~{R})-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-[(2~{R})-3-methoxy-2-[(2~{R},4~{S},5~{S},6~{S})-5-[(2~{S},4~{R},5~{R},6~{R})-
• Specifications & Purity: ≥95%
• Source: Amycolatopsissp. MST-AS5912
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads

Product Description

Apoptolidin is a selective polyketide, apoptosis inducer produced by|Nocardiopsis|mainly inducing cell death in E1A-transformed cells and inhibiting the enzymatic activity of mitochondrial F|0|F|1|-ATPase. In addition, studies suggest that apoptolidin isomerizes in solution into isoapoptolidin within the time frame of most cell-based assays, however isoapoptolidin's ability to inhibit mitochondrial F|0|F|1|--ATPase is over 10 fold less effective. Furthermore, studies show that apoptolidin induced apoptosis can be inhibited by BCL-2.