APRIL, CAS No.rp173490, B cell maturation antigen;TACI

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    Item Number
    rp173490
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp173490-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp173490-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90
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    B cell maturation antigen TACI

    Basic Description

    Product NameAPRIL, CAS No.rp173490
    SynonymsA proliferation-inducing ligand;TALL2;TNF- and APOL-related leukocyte expressed ligand 2;TNF-related death ligand 1;TRDL-1;ZTNF2
    GradeMoligand™
    Specifications & PurityMoligand™
    Mechanism of actionB cell maturation antigen;TACI

    Associated Targets(Human)

    TNFRSF13B Tbio Tumor necrosis factor receptor superfamily member 13B (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    TNFRSF17 Tclin Tumor necrosis factor receptor superfamily member 17 (0 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

    Product Specifications

    CASrp173490

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    Genetic information

    Alternate NamesA proliferation-inducing ligand;TALL2;TNF- and APOL-related leukocyte expressed ligand 2;TNF-related death ligand 1;TRDL-1;ZTNF2
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    Related Documents

    References

    1. Wu Y, Bressette D, Carrell JA, Kaufman T, Feng P, Taylor K, Gan Y, Cho YH, Garcia AD, Gollatz E et al..  (2000)  Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS..  J Biol Chem,  275  (45): (35478-85).  [PMID:10956646] [10.1021/op500134e]
    2. López-Fraga M, Fernández R, Albar JP, Hahne M.  (2001)  Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase..  EMBO Rep,  (10): (945-51).  [PMID:11571266] [10.1021/op500134e]
    3. Belnoue E, Pihlgren M, McGaha TL, Tougne C, Rochat AF, Bossen C, Schneider P, Huard B, Lambert PH, Siegrist CA.  (2008)  APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells..  Blood,  111  (5): (2755-64).  [PMID:18180376] [10.1021/op500134e]
    4. Samy E, Wax S, Huard B, Hess H, Schneider P.  (2017)  Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases..  Int Rev Immunol,  36  (1): (3-19).  [PMID:28215100] [10.1021/op500134e]
    5. Cogollo E, Cogollo E, Silva MA, Isenberg D.  (2015)  Profile of atacicept and its potential in the treatment of systemic lupus erythematosus..  Drug Des Devel Ther,  (13): (1331-9).  [PMID:25834391] [10.1021/op500134e]
    6. Hahne M, Kataoka T, Schröter M, Hofmann K, Irmler M, Bodmer JL, Schneider P, Bornand T, Holler N, French LE et al..  (1998)  APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth..  J Exp Med,  188  (6): (1185-90).  [PMID:9743536] [10.1021/op500134e]

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