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APY 29 - ≥98%(HPLC), high purity , CAS No.1216665-49-4
Inhibits IRE1α autophosphorylation; activates IRE1α endoribonuclease activity
Basic Description Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Allosteric modulator of IRE1α. Inhibits IRE1αautophosphorylation (IC50= 280 nM) and activates IRE1αribonuclease activity.APY29 is a small molecule that inhibits the kinase activity of IRE1α (in vitro autophosphorylation IC50 = 280 nM) by targeting its act Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Product Describtion:
APY29 is considered as a type I kinase inhibitor of inositol requiring kinase enzyme 1 α (IRE1α).
Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 2-N-(3H-benzimidazol-5-yl)-4-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine INCHI InChI=1S/C17H16N8/c1-2-10(1)13-8-16(25-24-13)22-15-5-6-18-17(23-15)21-11-3-4-12-14(7-11)20-9-19-12/h3-10H,1-2H2,(H,19,20)(H3,18,21,22,23,24,25) InChi Key WJNBSTLIALIIEW-UHFFFAOYSA-N Canonical SMILES C1CC1C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)N=CN5 Isomeric SMILES C1CC1C2=CC(=NN2)NC3=NC(=NC=C3)NC4=CC5=C(C=C4)N=CN5 PubChem CID 42627755 Molecular Weight 332.36
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 33.24, Max Conc. mM: 100; Solvent:1eq. HCl, Max Conc. mg/mL: 16.62, Max Conc. mM: 50 Melt Point(°C) >280°C
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B2218288