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AR-42 - 98%, high purity , CAS No.935881-37-1
Basic Description
| Synonyms | AC-5612 | DB12707 | NCGC00263153-01 | CCG-208672 | NCGC00263153-05 | AR-42 - HDAC-42 | CHEBI:188197 | (S)-HDAC 42 | AR 42 | UNII-E0GG29V0AQ | HMS3648K08 | N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide | BCP9000313 | OSU-HDAC42 | E0GG29V0AQ |
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| Specifications & Purity | ≥98% |
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| Biochemical and Physiological Mechanisms |
AR-42 is a novel HDAC inhibitor with an IC50 of 0.61 μM for acute lymphoblastic leukemia (697) cell lines. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Note | 2mg卖完停产，不再备货 |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | N-hydroxy-4-[[(2S)-3-methyl-2-phenylbutanoyl]amino]benzamide |
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| INCHI | InChI=1S/C18H20N2O3/c1-12(2)16(13-6-4-3-5-7-13)18(22)19-15-10-8-14(9-11-15)17(21)20-23/h3-12,16,23H,1-2H3,(H,19,22)(H,20,21)/t16-/m0/s1 |
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| InChi Key | LAMIXXKAWNLXOC-INIZCTEOSA-N |
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| Canonical SMILES | CC(C)C(C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO |
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| Isomeric SMILES | CC(C)[C@@H](C1=CC=CC=C1)C(=O)NC2=CC=C(C=C2)C(=O)NO |
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| PubChem CID | 6918848 |
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| Molecular Weight | 312.36 |
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Chemical and Physical Properties
| Solubility | DMSO 63 mg/mL Water <1 mg/mL Ethanol 63 mg/mL |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS08, GHS07 |
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| Signal | Danger |
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| Hazard Statements | H302:Harmful if swallowed H332:Harmful if inhaled H360:May damage fertility or the unborn child H312+H332:Harmful in contact with skin or if inhaled |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
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