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AR 420626 - ≥98%(HPLC), high purity , CAS No.1798310-55-0

  • ≥98%(HPLC)
Item Number
A287232
Grouped product items
SKUSizeAvailabilityPrice Qty
A287232-5mg
5mg
In stock
$88.90
A287232-10mg
10mg
In stock
$147.90
A287232-25mg
25mg
In stock
$325.90
A287232-50mg
50mg
In stock
$523.90
A287232-100mg
100mg
In stock
$840.90
A287232-250mg
250mg
In stock
$1,892.90
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FFA3 agonist

Basic Description

Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsFFA3 agonist (pEC50= 5.74). Inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. Also suppresses serotonin-induced fecal output in rats.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

product description：

AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM. AR420626 inhibits nicotine and serotonin-induced changes in motility of isolated muscle strips from rat colon and suppresses serotonin-induced fecal output in rats。

Associated Targets(Human)

CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR1 Tchem Free fatty acid receptor 1 (4763 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR3 Tchem Free fatty acid receptor 3 (304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR2 Tchem Free fatty acid receptor 2 (545 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name N-(2,5-dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide
INCHI InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
InChi Key GGTYQECCGLBHGS-UHFFFAOYSA-N
Canonical SMILES CC1=C(C(C2=C(N1)CCCC2=O)C3=CC=CO3)C(=O)NC4=C(C=CC(=C4)Cl)Cl
Isomeric SMILES CC1=C(C(C2=C(N1)CCCC2=O)C3=CC=CO3)C(=O)NC4=C(C=CC(=C4)Cl)Cl
PubChem CID 91885415
Molecular Weight 417.29

Certificates

Certificate of Analysis(COA)

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6 results found

Lot NumberCertificate TypeDateItem
H2218183Certificate of AnalysisJun 02, 2022 A287232
H2218184Certificate of AnalysisJun 02, 2022 A287232
H2218185Certificate of AnalysisJun 02, 2022 A287232
H2218186Certificate of AnalysisJun 02, 2022 A287232
H2218188Certificate of AnalysisJun 02, 2022 A287232
H2218190Certificate of AnalysisJun 02, 2022 A287232

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 20.86, Max Conc. mM: 50

Related Documents

 SDS

 Specification Sheet

Solution Calculators

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