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SKU | Size | Availability | Price | Qty |
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A424221-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
Highly selective GSK-3 inhibitor
Synonyms | AR-A014418 | 487021-52-3 | GSK-3beta Inhibitor VIII | N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA | 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea | 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea | AR-AO-14418 | AR-A 014418 | AR-AO 14418 | GSK-3b | S |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC50 = 104 nM), in an ATP-competitive manner (Ki = 38 n |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | AR-A014418 is a selective and effective GSK3β inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases. |
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IUPAC Name | 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea |
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INCHI | InChI=1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17) |
InChi Key | YAEMHJKFIIIULI-UHFFFAOYSA-N |
Canonical SMILES | COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-] |
Isomeric SMILES | COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-] |
WGK Germany | 3 |
PubChem CID | 448014 |
Molecular Weight | 308.31 |
Enter Lot Number to search for COA:
Melt Point(°C) | 211-213oC |
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Pictogram(s) | GHS05, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H335:May cause respiratory irritation H302:Harmful if swallowed H318:Causes serious eye damage |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
WGK Germany | 3 |