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Arachidonylethanolamide - ≥98%, high purity , CAS No.94421-68-8, Channel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3;Agonist of CB 1 receptor;Agonist of CB 2 receptor;Allosteric modulator of glycine receptor α1 subunit;Agonist of GPR18;Agonist of GPR55;Channel blocker of K 2P3.1;Inhibitor o

  • Moligand™
  • ≥98%
Item Number
A274932
Grouped product items
SKUSizeAvailabilityPrice Qty
A274932-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$75.90
A274932-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$279.90

Endogenous cannabinoid

Basic Description

SynonymsAnandamide|Arachidonylethanolamide|94421-68-8|Arachidonoyl ethanolamide|N-Arachidonoylethanolamine|N-arachidonoyl ethanolamine|arachidonoylethanolamide|(5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide|AEA|Anandamide (20.4, n-6)|N-Arachidonoy
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsAn arachidonic acid derivative that is an endogenous ligand for the CB cannabinoid receptor and for the VR1 vanilloid receptor. Inhibits calcium currents in neuroblastomas and neurons. Activates the MAP kinase signaling pathway. Inhibits proliferation and
Storage TempProtected from light,Store at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeACTIVATOR, AGONIST, ALLOSTERIC MODULATOR, CHANNEL BLOCKER, INHIBITOR
Mechanism of actionChannel blocker of Ca v3.1;Channel blocker of Ca v3.2;Channel blocker of Ca v3.3;Agonist of CB 1 receptor;Agonist of CB 2 receptor;Allosteric modulator of glycine receptor α1 subunit;Agonist of GPR18;Agonist of GPR55;Channel blocker of K 2P3.1;Inhibitor o
NoteProviding storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C (desiccating conditions).

Associated Targets

CNR1 Tclin Cannabinoid receptor 1 16 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CNR2 Tchem Cannabinoid receptor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR18 Tchem N-arachidonyl glycine receptor 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GPR55 Tclin G-protein coupled receptor 55 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CYP51A1 Tchem Lanosterol 14-alpha demethylase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CACNA1H Tclin Voltage-dependent T-type calcium channel subunit alpha-1H 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SLC22A6 Tclin Solute carrier family 22 member 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

VDR Tclin Vitamin D3 receptor 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FTL Tbio Ferritin light chain 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KMT2A Tchem Histone-lysine N-methyltransferase 2A 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

FAAH Tchem Fatty-acid amide hydrolase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 7 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPV2 Tchem Transient receptor potential cation channel subfamily V member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

POLK Tbio DNA polymerase kappa 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALOX15B Tchem Arachidonate 15-lipoxygenase B 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CACNA1G Tclin Voltage-dependent T-type calcium channel subunit alpha-1G 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CACNA1I Tclin Voltage-dependent T-type calcium channel subunit alpha-1I 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

BLM Tchem Bloom syndrome protein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TRPM8 Tclin Transient receptor potential cation channel subfamily M member 8 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNK2 Tclin Potassium channel subfamily K member 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNK3 Tclin Potassium channel subfamily K member 3 3 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

GLRA1 Tclin Glycine receptor subunit alpha-1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNK9 Tclin Potassium channel subfamily K member 9 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KCNA2 Tclin Potassium voltage-gated channel subfamily A member 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide
INCHI InChI=1S/C22H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22(25)23-20-21-24/h6-7,9-10,12-13,15-16,24H,2-5,8,11,14,17-21H2,1H3,(H,23,25)/b7-6-,10-9-,13-12-,16-15-
InChi Key LGEQQWMQCRIYKG-DOFZRALJSA-N
Canonical SMILES CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO
Isomeric SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO
PubChem CID 5281969
Molecular Weight 347.543

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

9 results found

Lot NumberCertificate TypeDateItem
H2414233Certificate of AnalysisJul 26, 2024 A274932
H2414464Certificate of AnalysisJul 26, 2024 A274932
H2414466Certificate of AnalysisJul 26, 2024 A274932
H2414468Certificate of AnalysisJul 26, 2024 A274932
A2205215Certificate of AnalysisJul 12, 2023 A274932
A2205214Certificate of AnalysisJul 12, 2023 A274932
I2207232Certificate of AnalysisJun 15, 2023 A274932
I2207233Certificate of AnalysisJun 15, 2023 A274932
I2207238Certificate of AnalysisJun 15, 2023 A274932

Chemical and Physical Properties

SolubilitySupplied in ethanol (5 mg/ml)
SensitivityLight sensitive;Air sensitive;Heat sensitive;Moisture sensitive
Flash Point(°C)270 °C

Related Documents

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References

1. Ross RA.  (2003)  Anandamide and vanilloid TRPV1 receptors..  Br J Pharmacol,  140  (5): (790-801).  [PMID:14517174]
2. De Petrocellis L, Schiano Moriello A, Imperatore R, Cristino L, Starowicz K, Di Marzo V.  (2012)  A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons..  Br J Pharmacol,  167  (8): (1643-51).  [PMID:22861649]
3. Brighton PJ et al..  (2011)  Characterization of the endocannabinoid system, CB(1) receptor signalling and desensitization in human myometrium..  Br J Pharmacol,  164  (5): (1479-94).  [PMID:21486283]
4. Landucci E et al..  (2011)  CB1 receptors and post-ischemic brain damage: studies on the toxic and neuroprotective effects of cannabinoids in rat organotypic hippocampal slices..  Neuropharmacology,  60  (4): (674-82).  [PMID:21130785]
5. Kim J et al..  (2014)  Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts..  Front Physiol,  (100).  [PMID:24711795]

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