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Arbidol HCl - ≥99%, high purity , CAS No.131707-23-8
Broad-spectrum indole-based antiviral and anti-inflammatory used for influenza infection treatment
Basic Description Synonyms Umifenovir hydrochloride | 3',4',5',6',7',8'-hexahydro-1'H-spiro[cyclohexane-1,2'-quinazoline]-4'-one | SW154718-2 | SR-01000407641-1 | MFCD00344795 | FT-0679910 | Umifenovir HCl; Umifenovir hydrochloride | ethyl 6-bromo-4-((dimethylamino)methyl)-5-hydrox Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Broad-spectrum indole-based antiviral that has demonstrated activity against a number of enveloped and non-enveloped viruses. Used clinically to treat influenza. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate;hydrochloride INCHI InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H InChi Key OMZHXQXQJGCSKN-UHFFFAOYSA-N Canonical SMILES CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl Isomeric SMILES CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl WGK Germany 3 PubChem CID 9958103 Molecular Weight 513.88
Chemical and Physical Properties Solubility Soluble in Chloroform (3 mg/ml) and Methanol (5 mg/ml); DMSO 103 mg/mL Water <1 mg/mL Ethanol 22 mg/mL Sensitivity Moisture sensitive Melt Point(°C) 133-137°C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
Precautionary Statements P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P264: Wash hands [and …] thoroughly after handling.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
WGK Germany 3
Citations of This Product 1. Ziwei Guo, Huan He, Kunqian Liu, Shicheng Yang, Zihui Li, Chaochao Lai, Zhicheng Liao, Xiaomin Ren, Bin Huang, Xuejun Pan. (2023) Sunlight-induced degradation of COVID-19 antivirals arbidol in natural aquatic environments: Mechanisms, pathways and toxicity. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 347 (119113). [PMID:37769471 ] 2. Runhong Zhou, Jianan Hu, Jingnan Qiu, Shengsheng Lu, Haixing Lin, Ruifeng Huang, Shaofen Zhou, Guoqing Huang, Jian He. (2023) Phenolic compound SG-1 from Balanophora harlandii and its derivatives exert anti-influenza A virus activity via activation of the Nrf2/HO-1 pathway. BIOCHEMICAL PHARMACOLOGY, 210 (115495). [PMID:36918045 ]
References 1. Ziwei Guo, Huan He, Kunqian Liu, Shicheng Yang, Zihui Li, Chaochao Lai, Zhicheng Liao, Xiaomin Ren, Bin Huang, Xuejun Pan. (2023) Sunlight-induced degradation of COVID-19 antivirals arbidol in natural aquatic environments: Mechanisms, pathways and toxicity. JOURNAL OF ENVIRONMENTAL MANAGEMENT, 347 (119113). [PMID:37769471 ] 2. Runhong Zhou, Jianan Hu, Jingnan Qiu, Shengsheng Lu, Haixing Lin, Ruifeng Huang, Shaofen Zhou, Guoqing Huang, Jian He. (2023) Phenolic compound SG-1 from Balanophora harlandii and its derivatives exert anti-influenza A virus activity via activation of the Nrf2/HO-1 pathway. BIOCHEMICAL PHARMACOLOGY, 210 (115495). [PMID:36918045 ]
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