Grouped product items

SKU

Size

Availability

Price

Qty

A348021-50mg

50mg

In stock

$179.90

A348021-250mg

250mg

In stock

$618.90

A348021-1g

In stock

$1,717.90

Basic Description

Synonyms	Lopac0_000049 \| Methyl N-methyltetrahydronicotinate \| Q423515 \| Spectrum_000055 \| BSPBio_000324 \| L000795 \| 63-75-2 (free) \| Arecholine \| DTXCID502617 \| KBioSS_000435 \| Methyl 1,2,5, 6-tetrahydro-1-methylnicotinate \| Arecaidine methyl ester \| Prestwick1_0
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of M 1 receptor;Agonist of M 2 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor
Product Description	A cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Anthelmintic (Cestodes); cathartic.

Product Properties

pKa	pKa: 6.84
Ki Data	Muscarinic acetylcholine receptor M1: Ki= 3.33 nM (Mus musculus); Muscarinic acetylcholine receptor: Ki= 5.3 nM (rat); Muscarinic acetylcholine receptor M3: Ki= 7.4 nM (rat); Muscarinic acetylcholine receptor M4: Ki= 7.4 nM (rat)

Associated Targets(Human)

CHRM5 Tclin Muscarinic acetylcholine receptor M5 (0 Activities)

Discover Target: CHRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (2 Activities)

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 (2 Activities)

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (6 Activities)

Discover Target: CHRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (3 Activities)

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

Discover Target: CHRM2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

THRB Tclin Thyroid hormone receptor beta-1 (7926 Activities)

Discover Target: THRB

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SK-N-SH (1499 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ABCB11 Tchem Bile salt export pump (2311 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LMNA Tbio Prelamin-A/C (36751 Activities)

Discover Target: LMNA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PMP22 Tbio Peripheral myelin protein 22 (699 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRNB2 Tclin Neuronal acetylcholine receptor; alpha4/beta2 (3972 Activities)

Discover Target: CHRNB2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)

Discover Target: RUNX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM3 Tclin Muscarinic acetylcholine receptors; M2 & M3 (708 Activities)

Discover Target: CHRM3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptors; M1 & M2 (498 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

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Cavia porcellus (23802 Activities)

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Oryctolagus cuniculus (11301 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A9 (98 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

Discover Target: Txnrd1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Impa1 Inositol monophosphatase 1 (16203 Activities)

Discover Target: Impa1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FTL Ferritin light chain (43324 Activities)

Discover Target: FTL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Chrm1 Muscarinic acetylcholine receptor (3770 Activities)

Discover Target: Chrm1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Chrna3 Neuronal acetylcholine receptor (756 Activities)

Discover Target: Chrna3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

nAChRalpha5 Nicotinic acetylcholine receptor alpha 5 subunit (134 Activities)

Discover Target: nAChRalpha5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CACNA1C Voltage-dependent L-type calcium channel subunit alpha-1C (242 Activities)

Discover Target: CACNA1C

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488179679
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179679
IUPAC Name	methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
INCHI	InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
InChi Key	HJJPJSXJAXAIPN-UHFFFAOYSA-N
Canonical SMILES	CN1CCC=C(C1)C(=O)OC
Isomeric SMILES	CN1CCC=C(C1)C(=O)OC
PubChem CID	2230
Molecular Weight	155.19

Database links

PubChem CID	2230
DrugBank Ligand	DB04365
ChEBI	CHEBI:2814
Wikipedia	Arecoline
ChEMBL Ligand	CHEMBL7303
BindingDB Ligand	50003368
CAS Registry No.	63-75-2
GPCRdb Ligand	arecoline
PubChem SID	488179679

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
G2422527	Certificate of Analysis	Jun 10, 2022	A348021
H2205643	Certificate of Analysis	Jun 10, 2022	A348021
H2205644	Certificate of Analysis	Jun 10, 2022	A348021
H2205645	Certificate of Analysis	Jun 10, 2022	A348021

Chemical and Physical Properties

Solubility	Soluble in water, chloroform, DMSO, and methanol.
Refractive Index	n20D1.48 (Predicted)
Boil Point(°C)	209° C
Melt Point(°C)	27.46° C (Predicted)

Safety and Hazards(GHS)

Merck Index	1.12361111111111

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Ying Lu, Jianna Yu, Wen Liu, Guoxing Jing, Wenshan Li, Wenjie Liu. (2022) Quantitative determination of major alkaloids in areca nut products by high-performance liquid chromatography coupled with ion mobility spectrometry. JOURNAL OF SEPARATION SCIENCE, 45 (24): (4469-4477). [PMID:36250424] [10.1002/jssc.202200361]

References

1. Yang YR, Chang KC, Chen CL, Chiu TH. (2000) Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor.. Chin J Physiol, 43 (1): (23-8). [PMID:10857465] [10.1021/op500134e]
2. Ghelardini C, Galeotti N, Lelli C, Bartolini A. (2001) M1 receptor activation is a requirement for arecoline analgesia.. Farmaco, 56 (5-7): (383-5). [PMID:11482763] [10.1021/op500134e]
3. Xie DP, Chen LB, Liu CY, Zhang CL, Liu KJ, Wang PS. (2004) Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits.. Chin J Physiol, 47 (2): (89-94). [PMID:15481791] [10.1021/op500134e]
4. Christie JE, Shering A, Ferguson J, Glen AI. (1981) Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.. Br J Psychiatry, 138 (13): (46-50). [PMID:7023592] [10.1021/op500134e]
5. Ying Lu, Jianna Yu, Wen Liu, Guoxing Jing, Wenshan Li, Wenjie Liu. (2022) Quantitative determination of major alkaloids in areca nut products by high-performance liquid chromatography coupled with ion mobility spectrometry. JOURNAL OF SEPARATION SCIENCE, 45 (24): (4469-4477). [PMID:36250424] [10.1002/jssc.202200361]

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Arecoline - 98%, high purity , CAS No.63-75-2, Agonist of M 1 receptor;Agonist of M 2 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator