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Arecoline - 98%, high purity , CAS No.63-75-2, Agonist of M 1 receptor;Agonist of M 2 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor

Moligand™
≥98%

CAS#: 63-75-2
Formula: C₈H₁₃NO₂
Molecular Weight: 155.19
EC Number: 200-565-5
PubChem CID: 2230
PubChem SID: 488179679

Item Number

A348021

Grouped product items
SKU	Size	Availability	Price
A348021-50mg	50mg	In stock	$179.90
A348021-250mg	250mg	In stock	$618.90
A348021-1g	1g	In stock	$1,717.90

View related series

M1 receptor Agonist M2 receptor Agonist M3 receptor Agonist M4 receptor Agonist M5 receptor Agonist

Basic Description

Synonyms	arecoline\|63-75-2\|Arecolin\|Arecaline\|Arecholine\|Methylarecaiden\|Methylarecaidin\|Arekolin\|Arecoline base\|Arecaidine methyl ester\|3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-methyl-, methyl ester\|methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate\|
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of M 1 receptor;Agonist of M 2 receptor;Agonist of M 3 receptor;Agonist of M 4 receptor;Agonist of M 5 receptor
Product Description	A cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Anthelmintic (Cestodes); cathartic.

pKa

pKa: 6.84

Ki Data

Muscarinic acetylcholine receptor M1: Ki= 3.33 nM (Mus musculus); Muscarinic acetylcholine receptor: Ki= 5.3 nM (rat); Muscarinic acetylcholine receptor M3: Ki= 7.4 nM (rat); Muscarinic acetylcholine receptor M4: Ki= 7.4 nM (rat)

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2D6 Tclin Cytochrome P450 2D6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RUNX1 Tbio Runt-related transcription factor 1 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FTL Tbio Ferritin light chain 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PMP22 Tbio Peripheral myelin protein 22 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LMNA Tbio Prelamin-A/C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CACNA1C Tclin Voltage-dependent L-type calcium channel subunit alpha-1C 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNA3 Tclin Neuronal acetylcholine receptor subunit alpha-3 0 Activities

Discover Target: CHRNA3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM5 Tclin Muscarinic acetylcholine receptor M5 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 2 Activities

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 2 Activities

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 6 Activities

Discover Target: CHRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRNB2 Tclin Neuronal acetylcholine receptor subunit beta-2 0 Activities

Discover Target: CHRNB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABCB11 Tchem Bile salt export pump 0 Activities

Discover Target: ABCB11

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 3 Activities

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THRB Tclin Thyroid hormone receptor beta 0 Activities

Discover Target: THRB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IMPA1 Tclin Inositol monophosphatase 1 0 Activities

Discover Target: IMPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

Pubchem Sid	488179679
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179679
IUPAC Name	methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate
INCHI	InChI=1S/C8H13NO2/c1-9-5-3-4-7(6-9)8(10)11-2/h4H,3,5-6H2,1-2H3
InChi Key	HJJPJSXJAXAIPN-UHFFFAOYSA-N
Canonical SMILES	CN1CCC=C(C1)C(=O)OC
Isomeric SMILES	CN1CCC=C(C1)C(=O)OC
PubChem CID	2230
Molecular Weight	155.19

PubChem CID

DrugBank Ligand

ChEBI

Wikipedia

ChEMBL Ligand

BindingDB Ligand

CAS Registry No.

GPCRdb Ligand

PubChem SID

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

4 results found

Lot Number	Certificate Type	Date	Item
G2422527	Certificate of Analysis	Jun 10, 2022	A348021
H2205643	Certificate of Analysis	Jun 10, 2022	A348021
H2205644	Certificate of Analysis	Jun 10, 2022	A348021
H2205645	Certificate of Analysis	Jun 10, 2022	A348021

Solubility

Soluble in water, chloroform, DMSO, and methanol.

Refractive Index

n20D1.48 (Predicted)

Boil Point(°C)

209° C

Melt Point(°C)

27.46° C (Predicted)

References

1. Yang YR, Chang KC, Chen CL, Chiu TH. (2000) Arecoline excites rat locus coeruleus neurons by activating the M2-muscarinic receptor.. Chin J Physiol, 43 (1): (23-8). [PMID:10857465]
2. Ghelardini C, Galeotti N, Lelli C, Bartolini A. (2001) M1 receptor activation is a requirement for arecoline analgesia.. Farmaco, 56 (5-7): (383-5). [PMID:11482763]
3. Xie DP, Chen LB, Liu CY, Zhang CL, Liu KJ, Wang PS. (2004) Arecoline excites the colonic smooth muscle motility via M3 receptor in rabbits.. Chin J Physiol, 47 (2): (89-94). [PMID:15481791]
4. Christie JE, Shering A, Ferguson J, Glen AI. (1981) Physostigmine and arecoline: effects of intravenous infusions in Alzheimer presenile dementia.. Br J Psychiatry, 138 (3): (46-50). [PMID:7023592]

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