Arecoline hydrobromide - 98%, high purity , CAS No.300-08-3

  • ≥98%
Item Number
A107393
Grouped product items
SKUSizeAvailabilityPrice Qty
A107393-1g
1g
In stock
$31.90
A107393-5g
5g
In stock
$103.90
A107393-25g
25g
In stock
$411.90
A107393-100g
100g
In stock
$1,235.90

Muscarinic receptor agonist

Basic Description

SynonymsAreciline Hydrochloride,(S) | Nicotinic acid,2,5,6-tetrahydro-1-methyl-, methyl ester, hydrobromide | s2614 | SR-01000075307-1 | NCGC00093563-04 | UNII-24S79B9CX7 | BCP02923 | BCP9000314 | Q27253878 | NCGC00093563-03 | NICOTINIC ACID, 1,2,5,6-TETRAHYDRO-1
Specifications & Purity≥98%
Biochemical and Physiological MechanismsMuscarinic receptor agonist (EC 50 values are 7 (M 1 ), 95 (M 2 ), 11 (M 3 ), 410 (M 4 ) and 69 nM (M 5 )). Natural alkaloid. Induces decreased blood-brain barrier permeability.
Shipped InNormal
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM4 Tclin Muscarinic acetylcholine receptor M4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EDNRA Tclin Endothelin receptor ET-A (5008 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BLM Tchem Bloom syndrome protein (4248 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCOLN3 Tchem MCOLN3 protein (319 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
nompc Ion channel NompC (277 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trpc4 Short transient receptor potential channel 4 (1615 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488180964
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180964
IUPAC Name methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
INCHI InChI=1S/C8H13NO2.BrH/c1-9-5-3-4-7(6-9)8(10)11-2;/h4H,3,5-6H2,1-2H3;1H
InChi Key AXOJRQLKMVSHHZ-UHFFFAOYSA-N
Canonical SMILES CN1CCC=C(C1)C(=O)OC.Br
Isomeric SMILES CN1CCC=C(C1)C(=O)OC.Br
WGK Germany 3
RTECS QT2275000
PubChem CID 9301
Molecular Weight 236.11
Beilstein 3914826
Reaxy-Rn 3914826

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot NumberCertificate TypeDateItem
F2421100Certificate of AnalysisApr 01, 2024 A107393
G2410602Certificate of AnalysisApr 01, 2024 A107393
G2410068Certificate of AnalysisApr 01, 2024 A107393
F2213155Certificate of AnalysisMar 15, 2024 A107393
F2213157Certificate of AnalysisMar 15, 2024 A107393
F2213175Certificate of AnalysisMar 15, 2024 A107393
F2213176Certificate of AnalysisMar 15, 2024 A107393
D1809093Certificate of AnalysisJul 17, 2023 A107393
D1809092Certificate of AnalysisJul 17, 2023 A107393
I2110045Certificate of AnalysisJun 09, 2023 A107393
I2110046Certificate of AnalysisJun 09, 2023 A107393
I2110041Certificate of AnalysisJun 09, 2023 A107393
B2324081Certificate of AnalysisMar 01, 2023 A107393
J2028204Certificate of AnalysisAug 11, 2022 A107393
J2028202Certificate of AnalysisAug 11, 2022 A107393
E2311130Certificate of AnalysisSep 15, 2021 A107393
E2311126Certificate of AnalysisSep 15, 2021 A107393

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Chemical and Physical Properties

Melt Point(°C)171-175°C

Safety and Hazards(GHS)

Pictogram(s) GHS06
Signal Danger
Hazard Statements

H301:Toxic if swallowed

Precautionary Statements

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

WGK Germany 3
RTECS QT2275000
Reaxy-Rn 3914826
Merck Index 778

Related Documents

Citations of This Product

1. Xiao Run-mei, Wang Jun-jun, Chen Jing-ya, Sun Li-juan, Chen Yong.  (2014)  Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress.  JOURNAL OF TOXICOLOGICAL SCIENCES,  39  (4): (609-614).  [PMID:25056785] [10.2131/jts.39.609]

References

1. Xiao Run-mei, Wang Jun-jun, Chen Jing-ya, Sun Li-juan, Chen Yong.  (2014)  Effects of arecoline on hepatic cytochrome P450 activity and oxidative stress.  JOURNAL OF TOXICOLOGICAL SCIENCES,  39  (4): (609-614).  [PMID:25056785] [10.2131/jts.39.609]

Solution Calculators