Arg-AMS - ≥98.0%, high purity , CAS No.301351-95-1

Item Number

A649116

Grouped product items
SKU	Size	Availability	Price
A649116-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$550.90
A649116-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$850.90
A649116-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,750.90

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Basic Description

Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase , which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase , which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes. In Vitro Arg-AMS inhibits the Orn-activating domain of GrsB with an IC 50 value of 4.6 µM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid

Associated Targets(Human)

RARS Tchem Arginine--tRNA ligase, cytoplasmic (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RARS1 Tchem Arginyl-tRNA synthetase (4 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl N-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]sulfamate
INCHI	InChI=1S/C16H26N10O7S/c17-7(2-1-3-21-16(19)20)14(29)25-34(30,31)32-4-8-10(27)11(28)15(33-8)26-6-24-9-12(18)22-5-23-13(9)26/h5-8,10-11,15,27-28H,1-4,17H2,(H,25,29)(H2,18,22,23)(H4,19,20,21)/t7-,8+,10+,11+,15+/m0/s1
InChi Key	BPKLMCNLHSJSEL-JVEUSOJLSA-N
Canonical SMILES	C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COS(=O)(=O)NC(=O)C(CCCN=C(N)N)N)O)O)N
Isomeric SMILES	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COS(=O)(=O)NC(=O)[C@H](CCCN=C(N)N)N)O)O)N
PubChem CID	9983529
Molecular Weight	502.51

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Basic Description