An anti-psychotic selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole is a second generation atypical antipsychotic and anti-depressant with partial agonist activity at dopamine D2 and serotonin 5-HT1A recep
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST, ANTAGONIST, PARTIAL AGONIST
Mechanism of action
Serotonin 2a (5-HT2a) receptor antagonist
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM
A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity.
Aripiprazole has been used to study behavioral and neurochemical effects of aripiprazole treatment in juvenile spontaneously hypertensive rats (SHR), a model for attention deficit hyperactivity disorder (ADHD).
Aripiprazole has been used to study its effect on mammary tumorigenesis, mediated by retrovirus delivery of receptor tyrosine-protein kinase 2 or HRas proto-oncogene, GTPase or by transgenic expression of Wnt-1 (proto-oncoprotein). It has also been used to study its behavioral and neurochemical effects in juvenile spontaneously hypertensive rats.
1.Raedler LA. (2016) Aripiprazole Lauroxil (Aristada): Long-Acting Atypical Antipsychotic Injection Approved for the Treatment of Patients with Schizophrenia.. Am Health Drug Benefits, 9 (Spec Feature):(40-3). [PMID:27668044]
2.Aggarwal A, Gopalakrishna G, Lauriello J. (2016) Aripiprazole Lauroxil Long-Acting Injectable: The Latest Addition to Second-Generation Long-Acting Agents.. Clin Schizophr Relat Psychoses, 10 (1):(58-63). [PMID:27074333]
3.Rohde M, M Rk N, Håkansson AE, Jensen KG, Pedersen H, Dige T, J Rgensen EB, Holm R. (2014) Biological conversion of aripiprazole lauroxil - An N-acyloxymethyl aripiprazole prodrug.. Results Pharma Sci, 4 (3):(19-25). [PMID:25756003]
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K2211063