Aripiprazole - ≥99%, high purity , Serotonin 2a (5-HT2a) receptor antagonist, CAS No.129722-12-9, Serotonin 2a (5-HT2a) receptor antagonist

Item Number

A124880

• Synonyms: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril | Aripiprazole [USAN:INN:BAN] | Aripiprazole- Bio-X | HMS3373D04 | Asprito | BCP04902 | OPC-14597 | s1975 | Aripiprex | Pripiprazole | Abilify Maintena Kit | Abilify MyCite | ARIPIP
• Specifications & Purity: Moligand™, ≥99%
• Biochemical and Physiological Mechanisms: An anti-psychotic selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity. Aripiprazole is a second generation atypical antipsychotic and anti-depressant with partial agonist activity at dopamine D2 and serotonin 5-HT1A recep
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: AGONIST, ANTAGONIST, PARTIAL AGONIST
• Mechanism of action: Serotonin 2a (5-HT2a) receptor antagonist
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM

A selective dopamine D2-receptor antagonist showing autoreceptor agonist activity.

Aripiprazole has been used to study behavioral and neurochemical effects of aripiprazole treatment in juvenile spontaneously hypertensive rats (SHR), a model for attention deficit hyperactivity disorder (ADHD).

Aripiprazole has been used to study its effect on mammary tumorigenesis, mediated by retrovirus delivery of receptor tyrosine-protein kinase 2 or HRas proto-oncogene, GTPase or by transgenic expression of Wnt-1 (proto-oncoprotein). It has also been used to study its behavioral and neurochemical effects in juvenile spontaneously hypertensive rats.