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ARP 100 - 97%, high purity , CAS No.704888-90-4, Inhibitor of MMP2

Moligand™

≥97%

CAS#: 704888-90-4
Formula: C₁₇H₂₀N₂O₅S
Molecular Weight: 364.42
PubChem CID: 10044321

Item Number

A287330

Grouped product items
SKU	Size	Availability	Price
A287330-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$78.90
A287330-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$355.90
A287330-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$711.90

Selective inhibitor of MMP-2

View related series

MMP2 Inhibitor

Basic Description

Synonyms	ARP 100 \| 704888-90-4 \| ARP-100 \| ARP100 \| N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)acetamide \| N-Hydroxy-2-(N-isopropoxy-[1,1'-biphenyl]-4-ylsulfonamido)acetamide \| CHEMBL181244 \| N-hydroxy-2-[N-(propan-2-yloxy)(4-phenylbenzene)sulfonamido]acetamide \| MMP-2 Inh
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Selective inhibitor of MMP-2 (IC50= 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
Storage Temp	Store at 2-8°C,Desiccated
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of MMP2

Associated Targets(Human)

MMP13 Tchem Collagenase 3 (3 Activities)

Discover Target: MMP13

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP9 Tchem Matrix metalloproteinase-9 (5 Activities)

Discover Target: MMP9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP2 Tchem 72 kDa type IV collagenase (6 Activities)

Discover Target: MMP2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP16 Tchem Matrix metalloproteinase-16 (1 Activities)

Discover Target: MMP16

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP8 Tchem Neutrophil collagenase (1 Activities)

Discover Target: MMP8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MMP16 Tchem Matrix metalloproteinase 16 (81 Activities)

Discover Target: MMP16

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP3 Tchem Matrix metalloproteinase 3 (3433 Activities)

Discover Target: MMP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP8 Tchem Matrix metalloproteinase 8 (1942 Activities)

Discover Target: MMP8

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP14 Tchem Matrix metalloproteinase 14 (1592 Activities)

Discover Target: MMP14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP12 Tchem Matrix metalloproteinase 12 (1130 Activities)

Discover Target: MMP12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP7 Tchem Matrix metalloproteinase 7 (1073 Activities)

Discover Target: MMP7

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP1 Tchem Matrix metalloproteinase-1 (7046 Activities)

Discover Target: MMP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MMP3 Tchem Matrix metalloproteinase (2 and 3) (56 Activities)

Discover Target: MMP3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mmp13 Matrix metalloproteinase 13 (19 Activities)

Discover Target: Mmp13

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Adam17 ADAM17 (14 Activities)

Discover Target: Adam17

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp2 Matrix metalloproteinase-2 (12 Activities)

Discover Target: Mmp2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mmp9 Matrix metalloproteinase 9 (38 Activities)

Discover Target: Mmp9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-hydroxy-2-[(4-phenylphenyl)sulfonyl-propan-2-yloxyamino]acetamide
INCHI	InChI=1S/C17H20N2O5S/c1-13(2)24-19(12-17(20)18-21)25(22,23)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13,21H,12H2,1-2H3,(H,18,20)
InChi Key	PHGLPDURIUEELR-UHFFFAOYSA-N
Canonical SMILES	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2
Isomeric SMILES	CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2
PubChem CID	10044321
Molecular Weight	364.42

CAS Registry No.

PubChem CID

ChEMBL Ligand

RCSB PDB Ligand

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
B2219192	Certificate of Analysis	Jan 04, 2022	A287330
B2219193	Certificate of Analysis	Jan 04, 2022	A287330
B2219194	Certificate of Analysis	Jan 04, 2022	A287330

Solubility

Solvent:DMSO, Max Conc. mg/mL: 36.44, Max Conc. mM: 100

Sensitivity

Light sensitive

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