Artemisinin - 98%, high purity , CAS No.63968-64-9

14 Citations
Item Number
A110206
Grouped product items
SKUSizeAvailabilityPrice Qty
A110206-1g
1g
In stock
$54.90
A110206-5g
5g
In stock
$156.90
A110206-25g
25g
In stock
$705.90
A110206-100g
100g
In stock
$2,539.90

Antimalarial compound

Basic Description

SynonymsHMS3413P13 | KBioGR_000982 | NSC 369397 | AS-12692 | AKOS024457231 | HMS3713D17 | IDI1_000656 | Artemisininum | BDBM50088447 | MLS001304036 | Prestwick2_000498 | SMR000578089 | Spectrum_001351 | SR-01000802560-2 | quinghaosu | SPBio_002316 | Spectrum2_001
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsAntimalarial compound. Forms highly alkylating free radicals and reactive oxygen species (ROS°) on interaction with iron. Additionally shows anticancer and antitumor properties. Active in vivo .
Shipped InNormal
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

CYP2B6 Tchem Cytochrome P450 2B6 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
HMGCR Tclin HMG-CoA reductase (2475 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TOP1 Tclin DNA topoisomerase I (7553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACE Tclin Angiotensin-converting enzyme (1423 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DHODH Tclin Dihydroorotate dehydrogenase (2737 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2A6 Tchem Cytochrome P450 2A6 (2861 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-375 (9258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Breast carcinoma cell (217 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Caco-2 (12174 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CAKI-2 (27 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CCRF-CEM (65223 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COLO 205 (50209 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HL-60 (67320 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HT-29 (80576 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
K562 (73714 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MCF7 (126967 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MRC5 (9203 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SH-SY5Y (11521 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
THP-1 (11052 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
U-87 MG (3946 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
WI-38 (2654 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADR5000 cell line (115 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A-431 (6446 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-116 (91556 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEp-2 (3859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HFF (3142 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Melanoma cell line (83 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A2780 (11979 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ovarian cancer cell line (109 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KB (17409 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HeLa (62764 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BT-549 (31254 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HCT-15 (51914 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SMMC-7721 (5516 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC2 Tchem Canalicular multispecific organic anion transporter 1 (1191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCB11 Tchem Bile salt export pump (2311 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC3 Tbio Canalicular multispecific organic anion transporter 2 (718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-N-AS (237 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-N-DZ (143 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ABCC4 Tchem Multidrug resistance-associated protein 4 (785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BEAS-2B (690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L02 (4864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BE(2)-C (181 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptococcus neoformans (21258 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania major (2877 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium yoelii (6656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human betaherpesvirus 5 (5122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium yoelii nigeriensis (1119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei rhodesiense (7991 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-12 (7051 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L6 (7924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hemozoin (239 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cysteine protease falcipain-3 (47 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Falcipain 2 (539 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Blood (6 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasma (328 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chorioallantoic membrane (375 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DHODH Dihydroorotate dehydrogenase (fumarate) (195 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488184181
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184181
IUPAC Name (1R,4S,5R,8S,9R,12S,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one
INCHI InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
InChi Key BLUAFEHZUWYNDE-NNWCWBAJSA-N
Canonical SMILES CC1CCC2C(C(=O)OC3C24C1CCC(O3)(OO4)C)C
Isomeric SMILES C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)C
WGK Germany 2
RTECS KD4170000
PubChem CID 68827
Molecular Weight 282.33
Reaxy-Rn 4194670

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
B2318440Certificate of AnalysisFeb 22, 2023 A110206
B2318442Certificate of AnalysisFeb 22, 2023 A110206
K2208032Certificate of AnalysisNov 18, 2022 A110206
K2208036Certificate of AnalysisNov 18, 2022 A110206
K2208037Certificate of AnalysisNov 18, 2022 A110206
K2208038Certificate of AnalysisNov 18, 2022 A110206

Chemical and Physical Properties

SolubilitySoluble in Methanol
Specific Rotation[α]75 ° (C=0.5, MeOH)
Melt Point(°C)156-157°C

Safety and Hazards(GHS)

WGK Germany 2
RTECS KD4170000
Reaxy-Rn 4194670
Merck Index 817

Related Documents

Citations of This Product

1. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu.  (2024)  Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level.  DESALINATION,  572  (117124).  [PMID:2501086]
2. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng.  (2023)  Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether.  MOLECULES,  28  (21): (7452).  [PMID:37959871]
3. Huihui Liu, Qing Wang, Jingru Guo, Kai Feng, Yiling Ruan, Zhihao Zhang, Xin Ji, Jigang Wang, Tao Zhang, Xiaolian Sun.  (2023)  Prodrug-based strategy with a two-in-one liposome for Cerenkov-induced photodynamic therapy and chemotherapy.  JOURNAL OF CONTROLLED RELEASE,  364  (1): (206).  [PMID:37884209]
4. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu.  (2023)  Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  652  (3): (2005).  [PMID:37690308]
5. Wei-guang Yang, Ao Sun, Rong Zhu, Nan Liu, Wei-jie He, Lin-lin Liu.  (2023)  Exploration of Artemisinin Against IgA Nephropathy via AKT/Nrf2 Pathway by Bioinformatics and Experimental Validation.  Drug Design Development and Therapy,      [PMID:37309415]
6. Minjia Meng, Yi Li, Hui Peng, Binrong Li, Chuanxun Zhang, Jiajia Ren, Qingluola Ren, Yan Liu, Jianming Pan.  (2023)  Hydrophilic imprinted MnO2 nanowires “coating” membrane with ultrahigh adsorption capacity for highly selective separation of Artemisinin/Artemether.  CHEMICAL ENGINEERING JOURNAL,  466  (143020).  [PMID:]
7. Wang Qiaolin, Xu Lihe, Qin Zhengbo, Yang Xinyan, Zheng Xianfeng.  (2023)  Potential use of LIAD time-of-flight mass spectrometry for the detection of biomolecules: An example of detecting nucleobases in DNA.  AIP Advances,  13  (3):   [PMID:]
8. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu.  (2023)  Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport.  CHEMICAL ENGINEERING JOURNAL,  462  (142277).  [PMID:]
9. Cunhao Du, Lixiao Ni, Jakpa Wizi, Wenlu Sang, Shiyi Rong, Xianglan Li, Chu Xu, Yan Li, Xuqing Chen, Shiyin Li.  (2023)  The inhibition mechanism and death mode of Microcystis aeruginosa induced by the continuous pressure of artemisinin sustained-release microspheres (ASMs).  Algal Research-Biomass Biofuels and Bioproducts,  71  (103031).  [PMID:]
10. Yuting Gao, Wenli Liao, Ruyi Zhang, Yining Lei, Tao Chen, Lingling Wu, Manqin Li, Xinran Liu, Fei Cai.  (2023)  PK2/PKRs pathway is involved in the protective effect of artemisinin against trimethyltin chloride-induced hippocampal injury.  TOXICOLOGY,  486  (153432).  [PMID:36696940]
11. Cunhao Du, Wenlu Sang, Chu Xu, Zhiyun Jiang, Jiajia Wang, Yuanyi Fang, Chengjie Zhu, Jakpa Wizi, Muhammad Asif Akram, Lixiao Ni, Shiyin Li.  (2023)  Integrated transcriptomic and metabolomic analysis of Microcystis aeruginosa exposed to artemisinin sustained-release microspheres.  JOURNAL OF HAZARDOUS MATERIALS,  443  (130114).  [PMID:36368067]
12. Zhi-feng Cai, Hao-yang Li, Xian-song Wang, Can Min, Jia-qi Wen, Rui-xin Fu, Zi-yue Dai, Jing Chen, Ming-zhu Guo, Hui-juan Yang, Ping-ping Bai, Xiao-mi Lu, Tao Wu, Ying Wu.  (2022)  Highly luminescent copper nanoclusters as temperature sensors and “turn off” detection of oxytetracycline.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,  647  (129202).  [PMID:]
13. Susu Lin, Bingbing Ma, Qilin Gao, Jian Yang, Gang Lai, Runhao Lin, Bingxian Yang, Bing-Nan Han, Lian-Hua Xu.  (2022)  The 16α-Hydroxylation of Progesterone by Cytochrome P450 107X1 from Streptomyces avermitilis.  CHEMISTRY & BIODIVERSITY,  19  (5): (e202200177).  [PMID:35426465]
14. Yang Jinlan, Gao Yulan, Yang Li.  (2022)  Capillary-based fluorescence microsensor with polyoxometalates as nanozyme for rapid and ultrasensitive detection of artemisinin.  MICROCHIMICA ACTA,  189  (1): (1-8).  [PMID:34964917]

References

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6. Katarzyna Barbacka,Wanda Baer-Dubowska.  (2011-09-10)  Searching for artemisinin production improvement in plants and microorganisms..  Current pharmaceutical biotechnology,  12  ((11)): (1743-1751).  [PMID:21902625]
7. Chuan Fu,Jiying Yu,Jing Zou,Lin He,Yun Dong,Yuan Huang.  (2012-12-29)  [Determination of artemisinin in rat plasma with HPLC-mS and its application]..  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,  37  ((19)): (2964-2967).  [PMID:23270243]
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22. Jan Kolaczinski,Michael Macdonald,Sylvia Meek.  (2013-12-21)  Vector control to eliminate artemisinin resistant malaria in the Greater Mekong subregion..  The Lancet. Infectious diseases,  14  ((1)): (9-11).  [PMID:24355026]
23. Therese Ericsson,Jesper Sundell,Angelica Torkelsson,Kurt-Jürgen Hoffmann,Michael Ashton.  (2014-01-10)  Effects of artemisinin antimalarials on Cytochrome P450 enzymes in vitro using recombinant enzymes and human liver microsomes: potential implications for combination therapies..  Xenobiotica; the fate of foreign compounds in biological systems,  44  ((7)): (615-626).  [PMID:24400699]
24. Melissa D Conrad,Norbert LeClair,Emmanuel Arinaitwe,Humphrey Wanzira,Abel Kakuru,Victor Bigira,Mary Muhindo,Moses R Kamya,Jordan W Tappero,Bryan Greenhouse,Grant Dorsey,Philip J Rosenthal.  (2014-03-13)  Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children..  The Journal of infectious diseases,  210  ((3)): (344-353).  [PMID:24610872]
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