Call +1 (833) 552-7181 or Contact us Earn $25 in coupons on your first order with Aladdin!
Toggle Nav
My Cart
Search
Advanced Search
Menu
Sign In
྾
main product photo

Artesunate - 98%, high purity , CAS No.88495-63-0

23 Citations
Item Number
A107818
Grouped product items
SKUSizeAvailabilityPrice Qty
A107818-5g
5g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$50.90
A107818-25g
25g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$143.90
A107818-100g
100g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$516.90
Add to Wish List Compare
Bulk Order  SDS  DATASHEET

Semi-synthetic artemisinin derivative

View related series
Fused ring tetrahydropyrans Six-Membered Heterocyclic Compounds

Basic Description

Synonyms4-oxo-4-{[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0?,(1)(3).0?,(1)(3)]hexadecan-10-yl]oxy}butanoic acid | ARTESUNATE [WHO-DD] | NCGC00164600-15 | Q707939 | ARTESUNATE [WHO-IP] | HY-N0193 | UNII-60W3249T9M | 4-oxo
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsSemi-synthetic artemisinin (Asc - 1308 ) derivative. Induces apoptosis of vascular endothelial cells. Shows antiangiogenenic and antiparasitaemic effects in vivo . Orally active.
Storage TempStore at 2-8°C
Shipped InWet ice
GradeMoligand™
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Artesunate is a derivative of artemisinin and belongs to a class with antimicrobial properties. The compound is an active ingredient in the Chinese herb Artemisia annua and has been used in Malaria studies. Artesunate has been tested against 55 cell lines and demonstrated anti-cancer activity. Research shows that conditional expression of CDC25A heightens the sensitivity of tumor cells to artesunate.
A derivative of artemisinin

Product Properties

ALogP2.5

Associated Targets(Human)

ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TOP1 Tclin DNA topoisomerase I (7553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
EDNRA Tclin Endothelin receptor ET-A (5008 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Histidine-rich protein (528 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Schistosoma japonicum (780 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Fasciola hepatica (191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania donovani (89745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma cruzi (99888 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Toxoplasma gondii (4585 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium berghei (192651 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium yoelii (6656 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Schistosoma mansoni (6170 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human betaherpesvirus 5 (5122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hepatitis B virus (7925 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium yoelii nigeriensis (1119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHO (4503 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Vero (26788 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L6 (7924 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H22 (575 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hemozoin (239 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Chuk Inhibitor of nuclear factor kappa-B kinase subunit alpha (16 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ikbkb Inhibitor of nuclear factor kappa-B kinase subunit beta (81 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BCHE Cholinesterase (8742 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium malariae (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium vinckei petteri (380 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium vivax (152 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Echinococcus multilocularis (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TUBB2B Tubulin (2175 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium vinckei (20 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid
INCHI InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1
InChi Key FIHJKUPKCHIPAT-AHIGJZGOSA-N
Canonical SMILES CC1CCC2C(C(OC3C24C1CCC(O3)(OO4)C)OC(=O)CCC(=O)O)C
Isomeric SMILES C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C
PubChem CID 6917864
Molecular Weight 384.42
Reaxy-Rn 6003212

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

6 results found

Lot NumberCertificate TypeDateItem
E2305312Certificate of AnalysisJan 11, 2023 A107818
E2305613Certificate of AnalysisJan 11, 2023 A107818
G2328047Certificate of AnalysisJan 11, 2023 A107818
B2219326Certificate of AnalysisDec 30, 2021 A107818
B2219341Certificate of AnalysisDec 30, 2021 A107818
B2219525Certificate of AnalysisDec 30, 2021 A107818

Chemical and Physical Properties

SolubilitySoluble in DMSO (25 mg/mL), and ethanol (25 mg/mL).solubility acetone: 33.4 mg/mL.
Sensitivityheat sensitive
Specific Rotation[α]5.5° (C=1,CH2Cl2)
Melt Point(°C)133°C

Safety and Hazards(GHS)

Reaxy-Rn 6003212
Merck Index 818

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. Artesunate (WR-256283) - 10mM in DMSO, used for , CAS No. 88495-63-0(DMSO), by Aladdin Scientific
    Artesunate (WR-256283)

    Starting at $134.90

FAQs and Articles

FAQ
JAK-STAT Cell Signaling Pathway
Categories: Technical articles
Tags:
treat tumors leukemia JAK family kinases

Citations of This Product

How to Cite Aladdin Scientific Products?
1. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu.  (2024)  Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level.  DESALINATION,  572  (117124).  [PMID:2501086]
2. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng.  (2023)  Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether.  MOLECULES,  28  (21): (7452).  [PMID:37959871]
3. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu.  (2023)  Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  652  (3): (2005).  [PMID:37690308]
4. Li Yuan-Ce, Zhang Qi, Zhang Hong-Yang, Wang Yan-Wen, Sun Yu-Mei, Yang Bi-Juan, Yin Jun-Lin.  (2023)  Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK.  Frontiers in Pharmacology,  14  (1218467).  [PMID:37719860]
5. Jing Yan, Faguang Ma, Yilin Wu.  (2023)  Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design.  Materials Today Nano,  23  (100369).  [PMID:]
6. Xin Zhang, Zhifang Liang, Ying Zhou, Fang Wang, Shan Wei, Bing Tan, Yujie Guo.  (2023)  Artesunate Inhibits Apoptosis and Promotes Survival in Schwann Cells via the PI3K/AKT/mTOR Axis in Diabetic Peripheral Neuropathy.  BIOLOGICAL & PHARMACEUTICAL BULLETIN,  46  (6): (764-772).  [PMID:37258141]
7. Minjia Meng, Yi Li, Hui Peng, Binrong Li, Chuanxun Zhang, Jiajia Ren, Qingluola Ren, Yan Liu, Jianming Pan.  (2023)  Hydrophilic imprinted MnO2 nanowires “coating” membrane with ultrahigh adsorption capacity for highly selective separation of Artemisinin/Artemether.  CHEMICAL ENGINEERING JOURNAL,  466  (143020).  [PMID:]
8. Jie Lv, Xiaoyu Wang, Xue Zhang, Runpei Xu, Shuyang Hu, Shuangling Wang, Meng Li.  (2023)  Tumor microenvironment-responsive artesunate loaded Z-scheme heterostructures for synergistic photo-chemodynamic therapy of hypoxic tumor.  Asian Journal of Pharmaceutical Sciences,  18  (100798).  [PMID:37252037]
9. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu.  (2023)  Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport.  CHEMICAL ENGINEERING JOURNAL,  462  (142277).  [PMID:]
10. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan.  (2022)  A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy.  Frontiers in Pharmacology,  13    [PMID:36438812]
11. Peng Ji, Xianglong Wang, Jiabing Yin, Yansheng Yao, Wangqi Du.  (2022)  Amplification of ferroptosis with a liposomal nanoreactor cooperates with low-toxicity doxorubicin apoptosis for enhanced tumor chemotherapy.  Biomaterials Science,  10  (6): (1544-1553).  [PMID:35171184]
12. Sennan Qiao, Hansi Zhang, Fei Sun, Zhenyan Jiang.  (2021)  Molecular Basis of Artemisinin Derivatives Inhibition of Myeloid Differentiation Protein 2 by Combined in Silico and Experimental Study.  MOLECULES,  26  (18): (5698).  [PMID:34577169]
13. Miaomiao Long, Jiamin Xu, Wenjie Fang, Jing Mao, Jie Zhang, Shenhuan Liu, Lipeng Qiu.  (2021)  Enhanced delivery of artesunate by stimuli-responsive polymeric micelles for lung tumor therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  66  (102812).  [PMID:]
14. Fereja Shemsu Ligani, Fang Zhongying, Li Ping, Guo Jinhan, Fereja Tadesse Haile, Chen Wei.  (2021)  “Turn-off” sensing probe based on fluorescent gold nanoclusters for the sensitive detection of hemin.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (6): (1639-1649).  [PMID:33483839]
15. Mengqi Bai, Li Qiang, Minjia Meng, Binrong Li, Suao Wang, Yilin Wu, Li Chen, Jiangdong Dai, Yan Liu, Jianming Pan.  (2021)  Upper surface imprinted membrane prepared by magnetic guidance phase inversion method for highly efficient and selective separation of Artemisinin.  CHEMICAL ENGINEERING JOURNAL,  405  (126899).  [PMID:]
16. Huang Ming-Zhi, Zhuang Yong, Ning Xu, Zhang Hao, Shen Zhi-Min, Shang Xian-Wen.  (2020)  Artesunate inhibits osteoclastogenesis through the miR-503/RANK axis.  BIOSCIENCE REPORTS,  40  (7):   [PMID:32542308]
17. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu.  (2020)  Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design.  COMPOSITES PART B-ENGINEERING,  198  (108123).  [PMID:]
18. Zhu Wang, Qianqian Wang, Tao He, Wen Li, Yan Liu, Yuan Fan, Yanping Wang, Qi Wang, Jie Chen.  (2020)  The combination of artesunate and carboplatin exerts a synergistic anti-tumour effect on non-small cell lung cancer.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  47  (6): (1083-1091).  [PMID:32072678]
19. Peng Ji, Haiqin Huang, Shirui Yuan, Le Wang, Siqi Wang, Yiwei Chen, Na Feng, Hanitrarimalala Veroniaina, Ziheng Wu, Zhenghong Wu, Xiaole Qi.  (2019)  ROS-Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide-Containing Recombinant Apoferritin.  Advanced Healthcare Materials,  8  (23): (1900911).  [PMID:31701665]
20. Renjie Xu, Ting Han, Li Shen, Jianguo Zhao, Xiang’an Lu.  (2019)  Solubility Determination and Modeling for Artesunate in Binary Solvent Mixtures of Methanol, Ethanol, Isopropanol, and Propylene Glycol + Water.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,  64  (2): (755–762).  [PMID:]
21. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na.  (2018)  Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  37  (1): (1-14).  [PMID:30477536]
22. Ting Li, Qingwen Zeng, Xingming Chen, Guojiang Wang, Haiqing Zhang, Aihua Yu, Hairui Wang, Yang Hu.  (2018)  The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway.  Molecular Medicine Reports,  17  (6): (8385-8390).  [PMID:29693177]
23. Hailong Huang, Xianghui Wang, Hao Ge, Min Xu.  (2016)  Multifunctional Magnetic Cellulose Surface-Imprinted Microspheres for Highly Selective Adsorption of Artesunate.  ACS Sustainable Chemistry & Engineering,  4  (6): (3334–3343).  [PMID:]

References

1. Morris CA, Duparc S, Borghini-Fuhrer I, Jung D, Shin CS, Fleckenstein L.  (2011)  Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administration..  Malar J,  10  (13): (263).  [PMID:21914160]
2. Sanford M, McCormack PL.  (2015)  All chapters.  Guidelines for the Treatment of Malaria,  71  (13): (1755-70).  [PMID:26020088]
3. H Xu,Y He,X Yang,L Liang,Z Zhan,Y Ye,X Yang,F Lian,L Sun.  (2007-02-23)  Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes..  Rheumatology (Oxford, England),  46  ((6)): (920-926).  [PMID:17314215]
4. Emile B Gordon,Geoffrey T Hart,Tuan M Tran,Michael Waisberg,Munir Akkaya,Jeff Skinner,Severin Zinöcker,Mirna Pena,Takele Yazew,Chen-Feng Qi,Louis H Miller,Susan K Pierce.  (2015-06-04)  Inhibiting the Mammalian target of rapamycin blocks the development of experimental cerebral malaria..  mBio,  6  ((3)): (e00725-e00725).  [PMID:26037126]
5. Erica L L Warkus,Yusuke Marikawa.  (2017-02-12)  Exposure-Based Validation of an In Vitro Gastrulation Model for Developmental Toxicity Assays..  Toxicological sciences : an official journal of the Society of Toxicology,  157  ((1)): (235-245).  [PMID:28184906]
6. Doyoung Kim,Tetsuro Kobayashi,Benjamin Voisin,Jay-Hyun Jo,Keiko Sakamoto,Seon-Pil Jin,Michael Kelly,Helena B Pasieka,Jessica L Naff,Jon H Meyerle,Ijeoma D Ikpeama,Gary A Fahle,Fred P Davis,Sergio D Rosenzweig,Julie C Alejo,Stefania Pittaluga,Heidi H Kong,Alexandra F Freeman,Keisuke Nagao.  (2020-01-22)  Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report..  Nature medicine,  26  ((2)): (236-243).  [PMID:31959990]
7. Weiyu Zhang,Qiu Du,Piaopiao Bian,Zheng Xiao,Xin Wang,Yajuan Feng,Hou Feng,Ziyan Zhu,Nailin Gao,Diming Zhu,Xiang Fan,Yonghong Zhu.  (2020-08-15)  Artesunate exerts anti-prolactinoma activity by inhibiting mitochondrial metabolism and inducing apoptosis..  Annals of translational medicine,  8  ((14)): (858-858).  [PMID:32793702]
8. Shunyang Fan,Deyin Zhang,Fuyun Liu,Yuqi Yang,Hongliang Xu.  (2020-11-20)  Artesunate alleviates myocardial ischemia/reperfusion-induced myocardial necrosis in rats and hypoxia/reoxygenation-induced apoptosis in H9C2 cells via regulating the FAK/PI3K/Akt pathway..  Annals of translational medicine,  8  ((20)): (1291-1291).  [PMID:33209871]
9. Wei Li,Weike Mo,Dan Shen,Libo Sun,Juan Wang,Shan Lu,Jane M Gitschier,Bing Zhou.  (2005-09-20)  Yeast model uncovers dual roles of mitochondria in action of artemisinin..  PLoS genetics,  1  ((3)): (e36-e36).  [PMID:16170412]
10. Patrice Njomnang Soh,Benoît Witkowski,David Olagnier,Marie-Laure Nicolau,Maria-Concepcion Garcia-Alvarez,Antoine Berry,Françoise Benoit-Vical.  (2008-11-19)  In vitro and in vivo properties of ellagic acid in malaria treatment..  Antimicrobial agents and chemotherapy,  53  ((3)): (1100-1106).  [PMID:19015354]
11. Lisa Evans DeWald,Joshua C Johnson,Dawn M Gerhardt,Lisa M Torzewski,Elena Postnikova,Anna N Honko,Krisztina Janosko,Louis Huzella,William E Dowling,Ann E Eakin,Blaire L Osborn,Janet Gahagen,Liang Tang,Carol E Green,Jon C Mirsalis,Michael R Holbrook,Peter B Jahrling,Julie Dyall,Lisa E Hensley.  (2019-12-29)  In Vivo Activity of Amodiaquine against Ebola Virus Infection..  Scientific reports,  9  ((1)): (20199-20199).  [PMID:31882748]
12. Anais Laleve,Cristina Panozzo,Inge Kühl,Alexa Bourand-Plantefol,Jelena Ostojic,Abdoulaye Sissoko,Déborah Tribouillard-Tanvier,David Cornu,Angélique Burg,Brigitte Meunier,Marc Blondel,Jerome Clain,Nathalie Bonnefoy,Romain Duval,Geneviève Dujardin.  (2020-01-29)  Artemisinin and its derivatives target mitochondrial c-type cytochromes in yeast and human cells..  Biochimica et biophysica acta. Molecular cell research,  1867  ((5)): (118661-118661).  [PMID:31987792]
13. James P Hagen,Grant Darner,Samuel Anderson,Katie Higgins,Derek A Leas,Ananya Mitra,Victoria Mashinson,Tasloach Wol,Carlos Vera-Esquivel,Bret Belter,Monica Cal,Marcel Kaiser,Alexander Wallick,Rosalie C Warner,Paul H Davis.  (2020-03-18)  Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis..  Bioorganic chemistry,  97  (103590-103590).  [PMID:32179269]
14. Jingjing Zhen, Faguang Ma, Rongxin Lin, Ming Yan, Yilin Wu.  (2024)  Porous MOFs-based self-assembled membrane with specific rebinding nanocages for selective recognition and separation at molecular level.  DESALINATION,  572  (117124).  [PMID:2501086]
15. Weibai Bian, Ruixuan Zhang, Xiaohui Chen, Chuanxun Zhang, Minjia Meng.  (2023)  Three-Dimensional Porous PVDF Foam Imprinted Membranes with High Flux and Selectivity toward Artemisinin/Artemether.  MOLECULES,  28  (21): (7452).  [PMID:37959871]
16. Kaicheng Zhang, Rongxin Lin, Ming Yan, Yilin Wu.  (2023)  Click-chemistry synergic MXene-functionalized flexible skeleton membranes for accurate recognition and separation.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,  652  (3): (2005).  [PMID:37690308]
17. Li Yuan-Ce, Zhang Qi, Zhang Hong-Yang, Wang Yan-Wen, Sun Yu-Mei, Yang Bi-Juan, Yin Jun-Lin.  (2023)  Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt’s lymphoma cells by inhibiting AKT and ERK.  Frontiers in Pharmacology,  14  (1218467).  [PMID:37719860]
18. Jing Yan, Faguang Ma, Yilin Wu.  (2023)  Permselective and transparent wooden membrane with artemisinin-imprinted nanocages based on a MOFs@C3N4 self-assembly design.  Materials Today Nano,  23  (100369).  [PMID:]
19. Xin Zhang, Zhifang Liang, Ying Zhou, Fang Wang, Shan Wei, Bing Tan, Yujie Guo.  (2023)  Artesunate Inhibits Apoptosis and Promotes Survival in Schwann Cells via the PI3K/AKT/mTOR Axis in Diabetic Peripheral Neuropathy.  BIOLOGICAL & PHARMACEUTICAL BULLETIN,  46  (6): (764-772).  [PMID:37258141]
20. Minjia Meng, Yi Li, Hui Peng, Binrong Li, Chuanxun Zhang, Jiajia Ren, Qingluola Ren, Yan Liu, Jianming Pan.  (2023)  Hydrophilic imprinted MnO2 nanowires “coating” membrane with ultrahigh adsorption capacity for highly selective separation of Artemisinin/Artemether.  CHEMICAL ENGINEERING JOURNAL,  466  (143020).  [PMID:]
21. Jie Lv, Xiaoyu Wang, Xue Zhang, Runpei Xu, Shuyang Hu, Shuangling Wang, Meng Li.  (2023)  Tumor microenvironment-responsive artesunate loaded Z-scheme heterostructures for synergistic photo-chemodynamic therapy of hypoxic tumor.  Asian Journal of Pharmaceutical Sciences,  18  (100798).  [PMID:37252037]
22. Jing Yan, Kaicheng Zhang, Faguang Ma, Hang Cui, Yilin Wu.  (2023)  Scalable basswood-based PDA/GO-embedded self-assembly membrane within multilayered artemisinin-imprinted nanocage for high-selectivity cascading adsorption and transport.  CHEMICAL ENGINEERING JOURNAL,  462  (142277).  [PMID:]
23. Zhong Wenzhao, Guo Feng, Chen Fangman, Law Man-Kay, Lu Jun, Shao Dan, Yu Hua, Chan Ging, Chen Meiwan.  (2022)  A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy.  Frontiers in Pharmacology,  13    [PMID:36438812]
24. Peng Ji, Xianglong Wang, Jiabing Yin, Yansheng Yao, Wangqi Du.  (2022)  Amplification of ferroptosis with a liposomal nanoreactor cooperates with low-toxicity doxorubicin apoptosis for enhanced tumor chemotherapy.  Biomaterials Science,  10  (6): (1544-1553).  [PMID:35171184]
25. Sennan Qiao, Hansi Zhang, Fei Sun, Zhenyan Jiang.  (2021)  Molecular Basis of Artemisinin Derivatives Inhibition of Myeloid Differentiation Protein 2 by Combined in Silico and Experimental Study.  MOLECULES,  26  (18): (5698).  [PMID:34577169]
26. Miaomiao Long, Jiamin Xu, Wenjie Fang, Jing Mao, Jie Zhang, Shenhuan Liu, Lipeng Qiu.  (2021)  Enhanced delivery of artesunate by stimuli-responsive polymeric micelles for lung tumor therapy.  JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,  66  (102812).  [PMID:]
27. Fereja Shemsu Ligani, Fang Zhongying, Li Ping, Guo Jinhan, Fereja Tadesse Haile, Chen Wei.  (2021)  “Turn-off” sensing probe based on fluorescent gold nanoclusters for the sensitive detection of hemin.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  413  (6): (1639-1649).  [PMID:33483839]
28. Mengqi Bai, Li Qiang, Minjia Meng, Binrong Li, Suao Wang, Yilin Wu, Li Chen, Jiangdong Dai, Yan Liu, Jianming Pan.  (2021)  Upper surface imprinted membrane prepared by magnetic guidance phase inversion method for highly efficient and selective separation of Artemisinin.  CHEMICAL ENGINEERING JOURNAL,  405  (126899).  [PMID:]
29. Huang Ming-Zhi, Zhuang Yong, Ning Xu, Zhang Hao, Shen Zhi-Min, Shang Xian-Wen.  (2020)  Artesunate inhibits osteoclastogenesis through the miR-503/RANK axis.  BIOSCIENCE REPORTS,  40  (7):   [PMID:32542308]
30. Yilin Wu, Wendong Xing, Minjia Meng, Jian Lu, Faguang Ma, Jia Gao, Xinyu Lin, Chao Yu.  (2020)  Multiple-functional molecularly imprinted nanocomposite membranes for high-efficiency selective separation applications: An imitated core-shell TiO2@PDA-based MIMs design.  COMPOSITES PART B-ENGINEERING,  198  (108123).  [PMID:]
31. Zhu Wang, Qianqian Wang, Tao He, Wen Li, Yan Liu, Yuan Fan, Yanping Wang, Qi Wang, Jie Chen.  (2020)  The combination of artesunate and carboplatin exerts a synergistic anti-tumour effect on non-small cell lung cancer.  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,  47  (6): (1083-1091).  [PMID:32072678]
32. Peng Ji, Haiqin Huang, Shirui Yuan, Le Wang, Siqi Wang, Yiwei Chen, Na Feng, Hanitrarimalala Veroniaina, Ziheng Wu, Zhenghong Wu, Xiaole Qi.  (2019)  ROS-Mediated Apoptosis and Anticancer Effect Achieved by Artesunate and Auxiliary Fe(II) Released from Ferriferous Oxide-Containing Recombinant Apoferritin.  Advanced Healthcare Materials,  8  (23): (1900911).  [PMID:31701665]
33. Renjie Xu, Ting Han, Li Shen, Jianguo Zhao, Xiang’an Lu.  (2019)  Solubility Determination and Modeling for Artesunate in Binary Solvent Mixtures of Methanol, Ethanol, Isopropanol, and Propylene Glycol + Water.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,  64  (2): (755–762).  [PMID:]
34. Yao Yuyuan, Guo Qinglong, Cao Yue, Qiu Yangmin, Tan Renxiang, Yu Zhou, Zhou Yuxin, Lu Na.  (2018)  Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  37  (1): (1-14).  [PMID:30477536]
35. Ting Li, Qingwen Zeng, Xingming Chen, Guojiang Wang, Haiqing Zhang, Aihua Yu, Hairui Wang, Yang Hu.  (2018)  The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway.  Molecular Medicine Reports,  17  (6): (8385-8390).  [PMID:29693177]
36. Hailong Huang, Xianghui Wang, Hao Ge, Min Xu.  (2016)  Multifunctional Magnetic Cellulose Surface-Imprinted Microspheres for Highly Selective Adsorption of Artesunate.  ACS Sustainable Chemistry & Engineering,  4  (6): (3334–3343).  [PMID:]

Solution Calculators

Privacy Policy Website Terms of Use Return policy Terms and Conditions of Sale Cookie Policy Sales Policy
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
Copyright © 2023-present Aladdin Scientific Corp . All rights reserved.