AS 1949490 - 98%, high purity , CAS No.1203680-76-5, Inhibitor of INPPL1

Item Number

A287712

Grouped product items
SKU	Size	Availability	Price
A287712-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$98.90
A287712-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$157.90
A287712-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$315.90
A287712-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$505.90
A287712-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$910.90
A287712-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$2,049.90

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

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Synonyms	AS-16435 \| 3-[(4-Chlorophenyl)methoxy]-N-[(1S) -1-phenylethyl]thiophene-2-carboxamide \| AS 1949490 \| CS-0013879 \| SCHEMBL21857864 \| Q27074523 \| GTPL8878 \| 1203680-76-5 \| A898999 \| AKOS024457770 \| HY-18686 \| J-004322 \| SMR004701459 \| as1949490 \| AS-1949490
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Selective SHIP2 (inositol 5'-phosphatase 2 containing SH2 domain) inhibitor (IC50 values of mouse and human are 0.34μM and 0.62μM, respectively); compared with SHIP1, the affinity for SHIP2 is about 30 times . Increase insulin-induced phosphorylation of
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of INPPL1

IUPAC Name	3-[(4-chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
INCHI	InChI=1S/C20H18ClNO2S/c1-14(16-5-3-2-4-6-16)22-20(23)19-18(11-12-25-19)24-13-15-7-9-17(21)10-8-15/h2-12,14H,13H2,1H3,(H,22,23)/t14-/m0/s1
InChi Key	RFZPGNRLOKVZJY-AWEZNQCLSA-N
Canonical SMILES	CC(C1=CC=CC=C1)NC(=O)C2=C(C=CS2)OCC3=CC=C(C=C3)Cl
Isomeric SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)C2=C(C=CS2)OCC3=CC=C(C=C3)Cl
PubChem CID	44473434
Molecular Weight	371.88

Lot Number	Certificate Type	Date	Item
L2101148	Certificate of Analysis	Sep 06, 2024	A287712
L2101149	Certificate of Analysis	Sep 06, 2024	A287712
L2101150	Certificate of Analysis	Sep 06, 2024	A287712
L2101151	Certificate of Analysis	Sep 06, 2024	A287712
L2101152	Certificate of Analysis	Sep 06, 2024	A287712
L2101153	Certificate of Analysis	Sep 06, 2024	A287712

Solubility	Solvent:DMSO, Max Conc. mg/mL: 37.19, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 37.19, Max Conc. mM: 100
Melt Point(°C)	89 - 91°C

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

Basic Description