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AS 1949490 - 98%, high purity , CAS No.1203680-76-5, Inhibitor of INPPL1

  • Moligand™
  • ≥98%
Item Number
A287712
Grouped product items
SKUSizeAvailabilityPrice Qty
A287712-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$98.90
A287712-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$157.90
A287712-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$315.90
A287712-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$505.90
A287712-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$910.90
A287712-250mg
250mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$2,049.90

SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) inhibitor

View related series
INPPL1 Inhibitor

Basic Description

Synonyms1203680-76-5|as1949490|AS 1949490|AS-1949490|3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide|CHEMBL2337806|(S)-3-((4-Chlorobenzyl)oxy)-N-(1-phenylethyl)thiophene-2-carboxamide|MLS006010769|GTPL8878|SCHEMBL21857864|HMS3414B09|HMS3
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsSelective SHIP2 (inositol 5'-phosphatase 2 containing SH2 domain) inhibitor (IC50 values ​​of mouse and human are 0.34μM and 0.62μM, respectively); compared with SHIP1, the affinity for SHIP2 is about 30 times . Increase insulin-induced phosphorylation of
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of INPPL1

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

INPPL1 Tchem Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 2 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 3-[(4-chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
INCHI InChI=1S/C20H18ClNO2S/c1-14(16-5-3-2-4-6-16)22-20(23)19-18(11-12-25-19)24-13-15-7-9-17(21)10-8-15/h2-12,14H,13H2,1H3,(H,22,23)/t14-/m0/s1
InChi Key RFZPGNRLOKVZJY-AWEZNQCLSA-N
Canonical SMILES CC(C1=CC=CC=C1)NC(=O)C2=C(C=CS2)OCC3=CC=C(C=C3)Cl
Isomeric SMILES C[C@@H](C1=CC=CC=C1)NC(=O)C2=C(C=CS2)OCC3=CC=C(C=C3)Cl
PubChem CID 44473434
Molecular Weight 371.88

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 37.19, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 37.19, Max Conc. mM: 100
Melt Point(°C)89 - 91°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

Related Documents

References

1. Suwa A, Yamamoto T, Sawada A, Minoura K, Hosogai N, Tahara A, Kurama T, Shimokawa T, Aramori I.  (2009)  Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2..  Br J Pharmacol,  158  (3): (879-87).  [PMID:19694723]

Solution Calculators