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Asimadoline - 98%, high purity , Kappa opioid receptor agonist, CAS No.153205-46-0, Kappa opioid receptor agonist

Moligand™

≥98%

CAS#: 153205-46-0
Formula: C₂₇H₃₀N₂O₂
Molecular Weight: 414.54
PubChem CID: 179340

Item Number

A412116

Grouped product items
SKU	Size	Availability	Price
A412116-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$64.90
A412116-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$282.90
A412116-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$426.90
A412116-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$649.90

View related series

GPCR/G Protein Neuronal Signaling Opioid Receptor κ receptor Agonist

Basic Description

Synonyms	EMD-61753 \| Asimadoline (EMD-61753 \| Acetic acid, ((6,7-dichloro-2,3-dihydro-2-methyl-1-oxo-2-phenyl-1H-inden-5-yl)oxy)-, (+-)- \| AKOS027327580 \| BDBM50366356 \| ASIMADOLINE [MI] \| N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-di(ph
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Asimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Kappa opioid receptor agonist
Product Description	Information Asimadoline (EMD 61753) is a potent κ opioid receptor agonist with IC50 of 5.6 nM and 1.2 nM for guinea pig and human recombinant κ opioid receptor, respectively.

Associated Targets(Human)

OPRK1 Tclin Kappa-type opioid receptor (1 Activities)

Discover Target: OPRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu opioid receptor (19785 Activities)

Discover Target: OPRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRD1 Tclin Delta opioid receptor (15096 Activities)

Discover Target: OPRD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OPRK1 Tclin Kappa opioid receptor (16155 Activities)

Discover Target: OPRK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Abcb1b P-glycoprotein 1 (174 Activities)

Discover Target: Abcb1b

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Abcb1a P-glycoprotein 3 (492 Activities)

Discover Target: Abcb1a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Abcb1a P-glycoprotein 1 and 3 (MDR1a/MDR1b) (23 Activities)

Discover Target: Abcb1a

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide
INCHI	InChI=1S/C27H30N2O2/c1-28(25(21-11-5-2-6-12-21)20-29-18-17-24(30)19-29)27(31)26(22-13-7-3-8-14-22)23-15-9-4-10-16-23/h2-16,24-26,30H,17-20H2,1H3/t24-,25+/m0/s1
InChi Key	JHLHNYVMZCADTC-LOSJGSFVSA-N
Canonical SMILES	CN(C(CN1CCC(C1)O)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
Isomeric SMILES	CN([C@H](CN1CC[C@@H](C1)O)C2=CC=CC=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4
PubChem CID	179340
Molecular Weight	414.54

PubChem CID

ChEMBL Ligand

DrugBank Ligand

BindingDB Ligand

CAS Registry No.

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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7 results found

Lot Number	Certificate Type	Date	Item
I2423030	Certificate of Analysis	Aug 15, 2024	A412116
I2423031	Certificate of Analysis	Aug 15, 2024	A412116
I2423032	Certificate of Analysis	Aug 15, 2024	A412116
I2423033	Certificate of Analysis	Aug 15, 2024	A412116
I2423034	Certificate of Analysis	Aug 15, 2024	A412116
I2423035	Certificate of Analysis	Aug 15, 2024	A412116
I2423036	Certificate of Analysis	Aug 15, 2024	A412116

Signal

Warning

Hazard Statements

H302:Harmful if swallowed

H317:May cause an allergic skin reaction

Precautionary Statements

P280:Wear protective gloves/protective clothing/eye protection/face protection.

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Asimadoline - 98%, high purity , Kappa opioid receptor agonist, CAS No.153205-46-0, Kappa opioid receptor agonist

Basic Description

Product Properties

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

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