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ASP 2535 - 95%, high purity , CAS No.374886-51-8, Inhibitor of GlyT1

Moligand™

≥95%

CAS#: 374886-51-8
Formula: C₂₂H₁₈N₆O
Molecular Weight: 382.42
PubChem CID: 9800113

Item Number

A275113

Grouped product items
SKU	Size	Availability	Price
A275113-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$89.90
A275113-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$294.90
A275113-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$969.90

Potent and selective GlyT1 inhibitor

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GlyT1 Inhibitor

Basic Description

Synonyms	4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
Specifications & Purity	Moligand™, ≥95%
Biochemical and Physiological Mechanisms	In vitro：ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro； In vivo：ASP2535 (1-3 mg/kg, p.o.) improves the PCP-induced deficit in prepulse inhibition in rats[1]. ASP2535 (0.3-3 mg/kg;
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of GlyT1
Product Description	ASP2535 is a potent, selective, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease.

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-[3-(6-phenylpyridin-3-yl)-5-propan-2-yl-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole
INCHI	InChI=1S/C22H18N6O/c1-14(2)21-24-25-22(28(21)19-10-6-9-18-20(19)27-29-26-18)16-11-12-17(23-13-16)15-7-4-3-5-8-15/h3-14H,1-2H3
InChi Key	FQGLDGKVKDPVLO-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=NN=C(N1C2=CC=CC3=NON=C32)C4=CN=C(C=C4)C5=CC=CC=C5
Isomeric SMILES	CC(C)C1=NN=C(N1C2=CC=CC3=NON=C32)C4=CN=C(C=C4)C5=CC=CC=C5
PubChem CID	9800113
Molecular Weight	382.42

PubChem CID

9800113

CAS Registry No.

374886-51-8

ChEMBL Ligand

CHEMBL4303475

References

1. Harada K, Nakato K, Yarimizu J, Yamazaki M, Morita M, Takahashi S, Aota M, Saita K, Doihara H, Sato Y et al.. (2012) A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole), improves cognition in animal models of cognitive impairment in schizophrenia and Alzheimer's disease.. Eur J Pharmacol, 685 (1-3): (59-69). [PMID:22542656]

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ASP 2535 - 95%, high purity , CAS No.374886-51-8, Inhibitor of GlyT1

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

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Chemical and Physical Properties

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