ASP 9521 - 10mM in DMSO, high purity , CAS No.1126084-37-4

Item Number

A420655

Grouped product items
SKU	Size	Availability	Price	Qty
A420655-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor;orally bioavailable

Basic Description

Synonyms	ASP-9521 \| 1126084-37-4 \| ASP 9521 \| ASP9521 \| CHEMBL4513510 \| AA79G37CPR \| 1-{1-[(5-methoxy-1H-indol-2-yl)carbonyl]piperidin-4-yl}-2-methylpropan-2-ol \| (4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone \| (4-(2-Hydroxy-2-methylpropyl)-1-pipe
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor (IC50= 11 - 49 nM). Suppresses androstenedione-dependent protein-specific antigen (PSA) production and cell proliferation in LNCaP cellsin vitro. Orally bioavailable.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

AKR1C3 Tchem Aldo-keto reductase family 1 member C3 (2 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AR Tclin Androgen Receptor (11781 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AKR1C3 Tchem Aldo-keto-reductase family 1 member C3 (1414 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CWR22R (2180 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[4-(2-hydroxy-2-methylpropyl)piperidin-1-yl]-(5-methoxy-1H-indol-2-yl)methanone
INCHI	InChI=1S/C19H26N2O3/c1-19(2,23)12-13-6-8-21(9-7-13)18(22)17-11-14-10-15(24-3)4-5-16(14)20-17/h4-5,10-11,13,20,23H,6-9,12H2,1-3H3
InChi Key	OXSCPDKUZWPWFR-UHFFFAOYSA-N
Canonical SMILES	CC(C)(CC1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)OC)O
Isomeric SMILES	CC(C)(CC1CCN(CC1)C(=O)C2=CC3=C(N2)C=CC(=C3)OC)O
PubChem CID	25210792
Molecular Weight	330.42

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Basic Description