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SKU | Size | Availability | Price | Qty |
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A420576-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $241.90 |
Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
Synonyms | ASP3026 | 1097917-15-1 | ASP-3026 | ASP 3026 | N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine | UNII-HP4L6MXF10 | HP4L6MXF10 | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-y |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Biochemical and Physiological Mechanisms | Potent anaplastic lymphoma kinase (ALK) inhibitor (IC50= 3.5 nM). Also inhibits Ack and ROS1 activity (IC50values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+T cell anaplastic large-cell lymphoma (ALCL) cel |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | ASP3026 is a novel and selective inhibitor for ALK with IC50 of 3.5 nM. |
ALogP | 4.8 |
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IUPAC Name | 2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine |
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INCHI | InChI=1S/C29H40N8O3S/c1-21(2)41(38,39)27-8-6-5-7-25(27)33-29-31-20-30-28(34-29)32-24-10-9-23(19-26(24)40-4)36-13-11-22(12-14-36)37-17-15-35(3)16-18-37/h5-10,19-22H,11-18H2,1-4H3,(H2,30,31,32,33,34) |
InChi Key | MGGBYMDAPCCKCT-UHFFFAOYSA-N |
Canonical SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC |
Isomeric SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC |
PubChem CID | 25134326 |
Molecular Weight | 580.74 |
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