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ASP4058 - 98%, high purity , CAS No.952565-91-2, Agonist of S1P 1 receptor;Agonist of S1P 3 receptor;Agonist of S1P 4 receptor;Agonist of S1P 5 receptor

Item Number
A607778
Grouped product items
SKUSizeAvailabilityPrice Qty
A607778-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$109.90
A607778-5mg
5mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$283.90
A607778-10mg
10mg
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Production requires sourcing of materials. We appreciate your patience and understanding.
$479.90
A607778-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$937.90
A607778-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,089.90
A607778-100mg
100mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,479.90
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S1P1 receptor Agonist S1P3 receptor Agonist S1P4 receptor Agonist S1P5 receptor Agonist

Basic Description

SynonymsASP-4058 | 952565-91-2 | ASP-4058 free base | ASP4058 | 5-(5-(3-(Trifluoromethyl)-4-(((2S)-1,1,1-trifluoropropan-2-yl)oxy)phenyl)-1,2,4-oxadiazol-3-yl)-1H-benzimidazole | 952565-91-2 (free base) | 01J7526K2Q | 1H-Benzimidazole, 6-(5-(3-(trifluoromethyl)-4-((1S)-2,2,2-t
Specifications & PurityMoligand™, ≥98%
Storage TempProtected from light,Store at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST
Mechanism of actionAgonist of S1P 1 receptor;Agonist of S1P 3 receptor;Agonist of S1P 4 receptor;Agonist of S1P 5 receptor
Product Description

ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.

Associated Targets(Human)

S1PR5 Tclin Sphingosine 1-phosphate receptor 5 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR4 Tclin Sphingosine 1-phosphate receptor 4 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR1 Tclin Sphingosine 1-phosphate receptor 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR3 Tclin Sphingosine 1-phosphate receptor 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 3-(3H-benzimidazol-5-yl)-5-[3-(trifluoromethyl)-4-[(2S)-1,1,1-trifluoropropan-2-yl]oxyphenyl]-1,2,4-oxadiazole
INCHI InChI=1S/C19H12F6N4O2/c1-9(18(20,21)22)30-15-5-3-11(6-12(15)19(23,24)25)17-28-16(29-31-17)10-2-4-13-14(7-10)27-8-26-13/h2-9H,1H3,(H,26,27)/t9-/m0/s1
InChi Key NJNXCJPSMWKXHO-VIFPVBQESA-N
Canonical SMILES CC(C(F)(F)F)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=CC4=C(C=C3)N=CN4)C(F)(F)F
Isomeric SMILES C[C@@H](C(F)(F)F)OC1=C(C=C(C=C1)C2=NC(=NO2)C3=CC4=C(C=C3)N=CN4)C(F)(F)F
Alternate CAS 952565-91-2
PubChem CID 16755143
MeSH Entry Terms 5-(3-(trifluoromethyl)-4-(((2S)-1,1,1-trifluoropropan-2-yl)oxy)phenyl)-1,2,4-oxadiazol-3-yl)-1H-benzimidazole;ASP4058
Molecular Weight 442.31

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
F2426343Certificate of AnalysisMar 18, 2024 A607778
F2426344Certificate of AnalysisMar 18, 2024 A607778
F2426345Certificate of AnalysisMar 18, 2024 A607778
F2426346Certificate of AnalysisMar 18, 2024 A607778
F2426347Certificate of AnalysisMar 18, 2024 A607778
F2426348Certificate of AnalysisMar 18, 2024 A607778
F2426349Certificate of AnalysisMar 18, 2024 A607778
F2426350Certificate of AnalysisMar 18, 2024 A607778

Chemical and Physical Properties

SensitivityLight sensitive

Related Documents

 SDS

 Specification Sheet

References

1. Forrest M, Sun SY, Hajdu R, Bergstrom J, Card D, Doherty G, Hale J, Keohane C, Meyers C, Milligan J et al..  (2004)  Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes..  J Pharmacol Exp Ther,  309  (2): (758-68).  [PMID:14747617] [10.1021/op500134e]
2. Trifilieff A, Fozard JR.  (2012)  Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor..  J Pharmacol Exp Ther,  342  (2): (399-406).  [PMID:22570366] [10.1021/op500134e]
3. Yamamoto R, Aoki T, Koseki H, Fukuda M, Hirose J, Tsuji K, Takizawa K, Nakamura S, Miyata H, Hamakawa N et al..  (2017)  A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration..  Br J Pharmacol,  174  (13): (2085-2101).  [PMID:28409823] [10.1021/op500134e]
4. Yamamoto R, Okada Y, Hirose J, Koshika T, Kawato Y, Maeda M, Saito R, Hattori K, Harada H, Nagasaka Y et al..  (2014)  ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile..  PLoS ONE,  9  (10): (e110819).  [PMID:25347187] [10.1021/op500134e]

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