AST-487 (NVP-AST487) - 98%, high purity , Tyrosine-protein kinase receptor RET inhibitor, CAS No.630124-46-8, Tyrosine-protein kinase receptor RET inhibitor
AST-487 (NVP-AST487) - 98%, high purity , Tyrosine-protein kinase receptor RET inhibitor, CAS No.630124-46-8, Tyrosine-protein kinase receptor RET inhibitor
AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Tyrosine-protein kinase receptor RET inhibitor
Product Description
Information
AST-487 (NVP-AST487), a N,N'-diphenyl urea,is an ATP competitive inhibitor ofFlt3with ki of 0.12 μM.Besides FLT3, AST487 also inhibitsRET,KDR,c-KIT,and c-ABL kinasewith IC50 values below 1 μM.
1.Akeno-Stuart N, Croyle M, Knauf JA, Malaguarnera R, Vitagliano D, Santoro M, Stephan C, Grosios K, Wartmann M, Cozens R et al.. (2007) The RET kinase inhibitor NVP-AST487 blocks growth and calcitonin gene expression through distinct mechanisms in medullary thyroid cancer cells.. Cancer Res, 67 (14):(6956-64). [PMID:17638907]
2.Weisberg E, Roesel J, Bold G, Furet P, Jiang J, Cools J, Wright RD, Nelson E, Barrett R, Ray A et al.. (2008) Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells.. Blood, 112 (13):(5161-70). [PMID:18820131]
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I2217134