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AT13387 - 98%, high purity , Heat shock protein HSP90 inhibitor, CAS No.912999-49-6, Heat shock protein HSP90 inhibitor

≥98%

CAS#: 912999-49-6
Formula: C₂₄H₃₁N₃O₃
Molecular Weight: 409.52
PubChem CID: 11955716

Item Number

A127900

Grouped product items
SKU	Size	Availability	Price
A127900-5mg	5mg	In stock	$69.90
A127900-10mg	10mg	In stock	$99.90
A127900-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$253.90
A127900-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$405.90
A127900-250mg	250mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$687.90

Potent Hsp90 inhibitor

View related series

Cell Cycle/DNA Damage HSP Metabolic Enzyme/Protease

Basic Description

Synonyms	Onalespib\|912999-49-6\|AT13387\|AT-13387\|Onalespib (AT13387)\|(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone\|AT 13387\|ATI-13387X\|Q7Y33N57ZZ\|(2,4-Dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	AT13387 is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Heat shock protein HSP90 inhibitor
Note	Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets

CYP2C19 Tchem Cytochrome P450 2C19 0 Activities

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90B1 Tchem Endoplasmin 1 Activities

Discover Target: HSP90B1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 0 Activities

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AA1 Tchem Heat shock protein HSP 90-alpha 3 Activities

Discover Target: HSP90AA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HSP90AB1 Tchem Heat shock protein HSP 90-beta 2 Activities

Discover Target: HSP90AB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 0 Activities

Discover Target: KCNH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(2,4-dihydroxy-5-propan-2-ylphenyl)-[5-[(4-methylpiperazin-1-yl)methyl]-1,3-dihydroisoindol-2-yl]methanone
INCHI	InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3
InChi Key	IFRGXKKQHBVPCQ-UHFFFAOYSA-N
Canonical SMILES	CC(C)C1=CC(=C(C=C1O)O)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C
Isomeric SMILES	CC(C)C1=CC(=C(C=C1O)O)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C
PubChem CID	11955716
Molecular Weight	409.52

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10 results found

Lot Number	Certificate Type	Date	Item
E2429088	Certificate of Analysis	Apr 30, 2024	A127900
E2429089	Certificate of Analysis	Apr 30, 2024	A127900
E2429090	Certificate of Analysis	Apr 30, 2024	A127900
E2429091	Certificate of Analysis	Apr 30, 2024	A127900
E2429092	Certificate of Analysis	Apr 30, 2024	A127900
J2109155	Certificate of Analysis	Jul 10, 2023	A127900
J2109188	Certificate of Analysis	Jul 10, 2023	A127900
J2109189	Certificate of Analysis	Jul 10, 2023	A127900
J2109190	Certificate of Analysis	Jul 10, 2023	A127900
J2109191	Certificate of Analysis	Jul 10, 2023	A127900

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