AT406 (SM-406) - ≥98%, high purity , CAS No.1071992-99-8, Antagonist of baculoviral IAP repeat containing 2;Antagonist of baculoviral IAP repeat containing 3;Antagonist of X-linked inhibitor of apoptosis
AT406 (SM-406) - ≥98%, high purity , CAS No.1071992-99-8, Antagonist of baculoviral IAP repeat containing 2;Antagonist of baculoviral IAP repeat containing 3;Antagonist of X-linked inhibitor of apoptosis
AT-406 (formerly known as SM-406) is an orally bioavailable potent IAP (inhibitor of apoptosis protein) of XIAP, cIAP1, and cIAP2 with Ki of 66.4 nM, 1.9 nM, and 5.1 nM, respectively. This may restore and promote the induction of apoptosi
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ANTAGONIST
Mechanism of action
Antagonist of baculoviral IAP repeat containing 2;Antagonist of baculoviral IAP repeat containing 3;Antagonist of X-linked inhibitor of apoptosis
Associated Targets(Human)
BIRC2TchemBaculoviral IAP repeat-containing protein 2 (5 Activities)
1.Petersen SL, Wang L, Yalcin-Chin A, Li L, Peyton M, Minna J, Harran P, Wang X. (2007) Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis.. Cancer Cell, 12 (5):(445-56). [PMID:17996648][10.1021/op500134e]
2.Wu H, Tschopp J, Lin SC. (2007) Smac mimetics and TNFalpha: a dangerous liaison?. Cell, 131 (4):(655-8). [PMID:18022360][10.1021/op500134e]
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L2117091