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Glycine receptors
Atropine - 99%, high purity , Muscarinic acetylcholine receptor M2 antagonist, CAS No.51-55-8, Muscarinic acetylcholine receptor M2 antagonist

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Atropine - 99%, high purity , Muscarinic acetylcholine receptor M2 antagonist, CAS No.51-55-8, Muscarinic acetylcholine receptor M2 antagonist

Moligand™
≥99%

CAS#: 51-55-8
Formula: C₁₇H₂₃NO₃
Molecular Weight: 289.37
Beilstein Registry Number: 91260
EC Number: 200-104-8
MDL number: MFCD00022622
PubChem CID: 174174

Item Number

A135946

Grouped product items
SKU	Size	Availability	Price
A135946-250mg	250mg	In stock	$9.90
A135946-1g	1g	In stock	$19.90
A135946-5g	5g	In stock	$85.90

Potent, competitive, non-selective mAChR antagonist

View related series

Glycine Receptor (All subtypes) Antagonist Glycine Receptor (All subtypes) Subunit-specific M1 receptor Antagonist M2 receptor Antagonist M3 receptor Antagonist M4 receptor Antagonist M5 receptor Antagonist α2A-adrenoceptor Antagonist

Basic Description

Synonyms	ATROPINE\|dl-Hyoscyamine\|51-55-8\|Tropine tropate\|Atropen\|Atropin\|dl-Tropyltropate\|Atropinol\|Eyesules\|Isopto-atropine\|Troyl tropate\|hyoscyamine\|Atropina\|Atropin-flexiolen\|(+,-)-Tropyl tropate\|Atropin [German]\|Atropina [Italian]\|(+-)-hyoscyamine\|Tropine, tro
Specifications & Purity	99%
Storage Temp	Store at 2-8°C,Protected from light,Argon charged
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Muscarinic acetylcholine receptor M2 antagonist

Product Properties

ALogP	1.8

Associated Targets

CHRM5 Tclin Muscarinic acetylcholine receptor M5 9 Activities

Discover Target: CHRM5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 6 Activities

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 8 Activities

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 21 Activities

Discover Target: CHRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 10 Activities

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

Discover Target: ADRA2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate
INCHI	InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16?
InChi Key	RKUNBYITZUJHSG-PJPHBNEVSA-N
Canonical SMILES	CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
Isomeric SMILES	CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3
WGK Germany	3
RTECS	CK0700000
PubChem CID	174174
Molecular Weight	289.37
Beilstein	91260

Database links

ChEBI	CHEBI:16684
Wikipedia	Atropine
DrugBank Ligand	DB00572
CAS Registry No.	51-55-8
ChEMBL Ligand	CHEMBL517712
PubChem CID	174174
PEP	atropine
DrugCentral Ligand	260
GPCRdb Ligand	atropine

Certificates

Certificate of Analysis(COA)

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9 results found

Lot Number	Certificate Type	Date	Item
L2307231	Certificate of Analysis	Dec 12, 2023	A135946
L2307239	Certificate of Analysis	Dec 12, 2023	A135946
L2307240	Certificate of Analysis	Dec 12, 2023	A135946
L2307241	Certificate of Analysis	Dec 12, 2023	A135946
L2307242	Certificate of Analysis	Dec 12, 2023	A135946
L2307243	Certificate of Analysis	Dec 12, 2023	A135946
K2301123	Certificate of Analysis	Oct 21, 2023	A135946
K2301125	Certificate of Analysis	Oct 21, 2023	A135946
K2301136	Certificate of Analysis	Oct 21, 2023	A135946

Chemical and Physical Properties

Solubility	Soluble in dilute aqueous acid, ethanol.
Sensitivity	Light & Air sensitive.

Safety and Hazards(GHS)

Pictogram(s)	GHS06
Signal	Danger
Hazard Statements	H300+H330:Fatal if swallowed or if inhaled
Precautionary Statements	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P310:Immediately call a POISON CENTER or doctor/physician. P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection.
WGK Germany	3
RTECS	CK0700000

Alternative Products

References

1. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. (2018) Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.. Invest Ophthalmol Vis Sci, 59 (7): (2778-2791). [PMID:29860464]
2. Radzicki D et al.. (2017) Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.. J Neurosci, 37 (9): (2292-2304). [PMID:28137966]
3. Huang H et al.. (2019) M1 Macrophage Activated by Notch Signal Pathway Contributed to Ventilator-Induced Lung Injury in Chronic Obstructive Pulmonary Disease Model.. J Surg Res, 244 (358-367). [PMID:31323391]
4. Wang YJ et al.. (2017) The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain.. Anesth Analg, 124 (4): (1330-1338). [PMID:28002166]

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