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AUDA - ≥98%, high purity , CAS No.479413-70-2
an inhibitor of sEH and selective activator of PPARα
Basic Description Synonyms 12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid | CS-0029182 | HY-108570 | S0752 | MFCD12912267 | 12-(3-adamantan-1-yl-ureido)-dodecanoic acid | 12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid | AUDA, >=98% (HPLC) | pyrene carbo Specifications & Purity ≥98% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description AUDA is an inhibitor of soluble epoxide hydrolase (sEH, IC|50|= 18 nM in mice). AUDA has been shown to demonstrate hypotensive effects, accompanied by an increase in urinary epoxide-to-diol ratios. At a concentration of 10 μM, AUDA is able to activate peroxisome proliferator-activated receptor α (PPARα) 3-fold, while showing no ability to affect PPARδ or PPARγ.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 12-(1-adamantylcarbamoylamino)dodecanoic acid INCHI InChI=1S/C23H40N2O3/c26-21(27)10-8-6-4-2-1-3-5-7-9-11-24-22(28)25-23-15-18-12-19(16-23)14-20(13-18)17-23/h18-20H,1-17H2,(H,26,27)(H2,24,25,28) InChi Key XLGSEOAVLVTJDH-UHFFFAOYSA-N Canonical SMILES C1C2CC3CC1CC(C2)(C3)NC(=O)NCCCCCCCCCCCC(=O)O Isomeric SMILES C1C2CC3CC1CC(C2)(C3)NC(=O)NCCCCCCCCCCCC(=O)O PubChem CID 10069117 Molecular Weight 392.58
Chemical and Physical Properties Solubility Soluble in water (0.5 mg/ml at 25° C), 100% ethanol (4 mg/ml), DMSO (≥ 10 mg/ml at 60° C), DMF (~2 mg/ml), and DMF : PBS (pH 7.2) (1:1) (~0.5 mg/ml).Soluble in DMSO Refractive Index n20D1.53 (Predicted) Boil Point(°C) ~592.7° C at 760 mmHg (Predicted) Melt Point(°C) 228.39° C (Predicted)
Safety and Hazards(GHS) Signal Warning Hazard Statements H303: May be harmful if swallowed
Precautionary Statements P312: Call a POISON CENTER or doctor/... if you feel unwell.
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C2226376