Aurora A Inhibitor I | 1158838-45-9 | TC-S 7010 | N-(2-Chlorophenyl)-4-((2-((4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)benzamide | 2,4-Bisanilinopyrimidine, 10 | TCS7010 | Aurora-A-inhibitor-I | N-(2-Chlorophenyl)-4-(2-(4-(2-(4-
Specifications & Purity
Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms
Potent and selective inhibitor of Aurora kinase A (IC50= 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50values are 0.19 and 2.9μM respectively).
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of aurora kinase A;Inhibitor of aurora kinase B
Product Description
Aurora A Inhibitor I is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B.
1.Aliagas-Martin I, Burdick D, Corson L, Dotson J, Drummond J, Fields C, Huang OW, Hunsaker T, Kleinheinz T, Krueger E et al.. (2009) A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.. J Med Chem, 52 (10):(3300-7). [PMID:19402633]
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H2223207